Τόμος 14 (2000) – Τεύχος 2 – Άρθρο 1 – Επιθεώρηση Κλινικής Φαρμακολογίας και Φαρμακοκινητικής-Διεθνής Έκδοση – Volume 14 (2000) – Issue 2 – Article 1 – Epitheorese Klinikes Farmakologias και Farmakokinetikes-International Edition

Department of Pharmacology, Medical School, Aristotle University of Thessaloniki, Greece

Accepted for publication: 15 March 2000

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2.    Κοκκέβη A, Στεφανής K.: Τα ναρκωτικά στην Ελλάδα: η διαχρονική πορεία της χρήσης. Η χρήση εξαρτησιογόνων ουσιών στο γενικό και μαθητικό πληθυσμό. Αθήνα (1994)

3.    Hobbs WR, Rail TW, Verdoorn ΤΑ: Hypnotics and sedatives; ethanol. In Goodman, Gilman (eds.): The pharmacological basis of therapeutics. (9^th edition), pp 361- 396, McGraw Hill, New York (1996)

4.    Goldstein DB: Pharmacology of alcohol. Oxford University Press, New York (1983)

5.    Siegel GJ, Agranoff BW, Albers RW, Molinoff PB: Basic neurochemistry (5^th ed.). Raven Press, New York (1994).

6.    Saito T, Lee JM, Tabakoff B: Ethanol’s effects on cortical adenylate cyclase activity. J. Neurochem. 44: 1037-44 (1985)

7.    Valverius P, Hoffman PL, Tabakoff B: Effect of ethanol on mouse cerebral cortical beta-adrenergic receptors. Mol. Pharmacol. 32: 217-22 (1987)

8.    Charness ME, Simon RP, Greenberg DA: Ethanol and the nervous system. N. Eng.lJ. Med. 321: 442-54 (1989)

9.    Hoffman PL, Tabakoff B: Ethanol does not modify opiate-mediated inhibition of striatal adenylate cyclase. J. Neurochem. 46: 812-6 (1986)

10.  Rabin RA: Effect of ethanol on inhibition of striatal adenylate cyclase activity. Biochem. Pharmacol. 34: 4329-31 (1985)

11.  Deitrich RA, Dunwiddie TV, Harris RA, Erwin VG: Mechanism of action of ethanol: Initial central nervous system actions. Pharmacol. Rev. 41: 489-537 (1989)

12.  Hoffman PL, Tabakoff B: Ethanol and guanine nucleotide binding proteins: A selective interaction. FASEB J 4: 2612-2622 (1990)

13.  Miles MF, Diaz JE, Deguzman VS: Mechanisms of neuronal adaptation to ethanol: Ethanol induces Hsc70 gene transcription in NG108-15 neuroblastoma x glioma cells. J. Biol. Chem. 266: 2409-14 (1991)

14.  Singer DS, Parent LJ, Kolber MA: Ethanol: An enhancer of transplantation antigen expression. Alcohol. Clin. Exp. Res. 13: 480-4 (1989)

15.  Deutsch PJ, Hoeffler JP, Jameson L, Habener JF: Cyclic AMP and phorbol ester-stimulated transcription mediated by similar DNA elements that bind distinct proteins. Proc. Natl. Acad. Sci. USA 85: 7922-26 (1988)

16.  Roesler WJ, Vanderbark GR, Hanson RW: Cyclic AMP and the induction of eucaryotic gene transcription. J. Biol. Chem. 263: 9063-6 (1988)

17.  Lovinger DM: Alcohols and neurotransmitter gated ion channels: past, present and future. Naunyn-Schmiedeberg’s Arch. Pharmacol. 356: 267-282 (1997)

18.  Forman SA, Righi DL, Miller KW: Ethanol increases agonist affinity for nicotinic receptors from Torpedo Biochim. Biophys. Acta 987: 95-103 (1989)

19.  Abadji V, Raines DE, Dalton LA, Miller KW: Lipid-protein interactions and protein dynamics in vesicles containing the nicotinic acetylcholine receptor: a study with ethanol. Biochim. Biophys. Acta 1194: 25-34 (1994)

20.  Lovinger DM, White G, Weight FF: Ethanol inhibits NMDA-activated ion current in hippocampal neurons. Science 243: 1721 -1724 (1989)

21.  Hoffman PL, Rabe CS, Moses F, Tabakoff B: NMDA receptors and ethanol: inhibition of calcium flux and cGMP production. J. Neurochem. 52: 1937-1940 (1989)

22.  Li C., Peoples RW, Weight FF: Alcohol action on a neuronal membrane receptor: Evidence for a direct inter-action with the receptor protein. Proc Natl Acad Sci USA 91: 8200-8204 (1994)

23.  Peoples RW, Weight FF: Cutoff in potency implicates alcohol inhibition of NMDA receptors in alcohol intoxication. Proc. Natl. Acad. Sci USA 92: 2825-2829 (1995)

24.  Wafford KA, Burnett DM, Leidenheimer NJ, Burt DR, Wang JB, Kofuji P, Dunwiddie TV, Harris RA, Sikela JM: Ethanol sensitivity of the GABAA receptor expressed in Xenopus oocytes requires 8 aminoacids contained in the g2L subunit. Neuron 7: 27-33 (1991)

25.  Mihic SJ, Whiting PJ, Harris RA: Anaesthetic concentrations of alcohol potentiate GABA receptor-mediated currents: lack of subunit specificity. Eur. J. Pharmacol. 268: 209-214 (1994)

26.  Frye GD: Gamma-aminobutyric acid changes in alcohol withdrawal. In Porter RJ, Mattson RH, Cramer JA, Diamond I (Eds): Alcohol and Seizures: Basic mechanisms and clinical concepts. Philadelphia, Davis, 87-101 (1990)

27.  Greenberg DA, Cooper EC, Gordon A, Diamond I: Ethanol and the γ-aminobutyric acid-benzodiazepine receptor complex. J. Neurochem. 42: 1062-68 (1984)

28.  Buck KJ, Harris RA: Benzodiazepine agonist and in-verse agonist actions on GABAA receptor-operated chloride channels. II. Chronic effects of ethanol. J. Pharmacol. Exp. Ther. 253: 713-719 (1990)

29.  Morrow AL, Suzdak PD, Paul SM: Ethanol and the GABA/benzodiazepine receptor complex. In Porter RJ, Mattson RH, Cramer JA, Diamond I (Eds): Alcohol and Seizures: Basic mechanisms and clinical concepts. Philadelphia, Davis, pp 102-4 (1990)

30.  Mhatre M, Mehta AK, Ticku MK: Chronic ethanol ad-ministration increases the binding of the benzodiazepine inverse agonist and alcohol antagonist [³H]R015-4513 in rat brain. Eur J Pharmacol 141-5 (1988)

31.  Mhatre M, Ticku MK: Chronic ethanol treatment selectively increases the binding of inverse agonists for benzodiazepine binding sites in cultured spinal cord neurons. J. Pharmacol. Exp. Ther. 251: 164-8 (1989)

32.  Di Chiara G, Imperato A: Alcohol preferentially stimulates dopamine release from the nucleus accumbens in freely moving rats. Eur. J. Pharmacol. 115: 131-132 (1985)

33.  Di Chiara G, Imperato A: Preferential stimulation of dopamine release in the nucleus accumbens by opiates, alcohol, and barbiturates: Studies by transcerebral dialysis in freely moving rats. Ann. N.Y. Acad. Sci. 473: 367-381 (1986)

34.  Di Chiara G, Imperato A: Drugs abused by humans preferentially increase synaptic dopamine concentrations in the mesolimbic system of freely moving rats. Proc. Natl. Acad. Sci. USA 85: 5274-5278 (1988)

35.  Diana M, Pistis M, Carboni S, Gessa GL, Rosseti ZL: Profound decrement of mesolimbic dopaminergic neuronal activity during ethanol withdrawal syndrome in rats: Electrophysiological and biochemical evidence. Proc. Natl. Acad. Sci. USA 90: 7966-7969 (1993)

36.  Ollat H, Parvez H, Parvez S: Alcohol and central neurotransmission. Neurochem. Int. 13: 275-300 (1988)

37.  Lovinger DM, White G: Ethanol potentiation of 5-HT3 receptor-mediated ion current in neuroblastoma cells and adult mammalian neurons. Mol. Pharmacol. 40: 263-270 (1991)

38.  Ballenger J, Goodwin F, Major L, Brown G: Alcohol and central serotonin metabolism in man. Arch. Gen. Psychiatry 30: 324-327 (1979)

39.  Le AD, Khana JM, Kalant H, Leblanc AE: The effect of lesions in the dorsal, median and magnus raphe nuclei on the development of tolerance to ethanol. J. Pharmacol. Exp. Ther. 218: 525-529 (1981)

40.  Le AD, Khana JM, Kalant H, Leblanc AE: Effect of modification of brain serotonin (5-HT), norepinephrine (NE) and dopamine (DA) on ethanol tolerance. Psychopharmacology 75: 231-235 (1981)

41.  Mayhan GW, Didion SP: Acute effects of ethanol on responses of cerebral arterioles. Stroke 20: 2097-2102 (1995)

42.  Forney RB, Hanger RN: The alcohols. In Drill’s Pharmacology of medicine (4^th ed.) (JR DiPalma, Ed.) 275-302. McGraw-Hill, New York (1971)

43.  Miyakawa T, Yagi T, Kitazawa H, Yasuda M, Kawai N, Tsuboi K, Niki H.: Fyn-kinase as a determinant of ethanol sensitivity: relation to NMDA-receptor function. Science 278: 698-701 (1997)

44.  Weiner JL, Valenzuela CF, Watson PL, Frazier CJ, Dunwiddie TV: Elevation of basal protein kinase C activity increases ethanol sensitivity of GABA(A) receptors in rat hippocampal CA1 pyramidal neurons.: J. Neurochem. 68: 1949-1959 (1997)

45.  Chandler LJ, Harris RA, Crews FT: Ethanol tolerance and synaptic plasticity. TiPs 19: 491-495 (1998)

46.  Kalant H, Khana JM, Lin GY, Chung S: Ethanol: A direct inducer of drug metabolism. Biochem. Pharmacol. 25: 337-342 (1976)

47.  Lundquist F: The metabolism of alcohol. In Biological Basis of Alcoholism (Y. Israel and J Mardones, Eds.) pp. 1-52. Wiley, New York, 1971

48.  Ho C, Williams BW, Kelly MB, Stubbs CD: Chronic ethanol intoxication induces adaptive changes at the membrane protein/lipid interface. Biochim. Biophys. Acta 1189 (2): 135-142 (1994)

49.  Mhatre MC, Ticku MK: Chronic ethanol administration alters GABAA receptor gene expression. Mol. Pharmacol. 42: 415-422 (1992)

50.  Hu XJ, Ticku MK: Chronic ethanol treatment upregulates the NMDA receptor function and binding in mammalian cortical neurons. Mol. Brain Res. 30: 347-356 (1995)

51.  Ibbotson T, Field MJ, Boden PR: Effect of chronic ethanol treatment in vivo on excitability in mouse cortical neurons in vitro. Br. J. Pharmacol. 122: 956-962 (1997)

52.  Grant KA, Valverius P, Hudspith M, Tabakoff B: Ethanol withdrawal seizures and the NMDA receptor complex. Eur. J. Pharmacol. 176: 289-96 (1990)

53.  Morrow AL, Suzdak PD, Karanian JW, Paul SM: Chronic ethanol administration alters gamma-aminobutyric acid, pentobarbital and ethanol-mediated 36Cl-uptake in cerebral cortical synaptneurosomes. J. Pharmacol. Exp. Ther. 240: 158-164 (1988)

54.  Rosenblum K, Dudai Y, Richter-Levin G: Long-term potentiation increases tyrosine phosphorylation of the N- methyl-D-aspartate receptor subunit 2B in rat dentate gyrus in vivo. Proc. Natl. Acad. Sci. USA 93: 10457-10460 (1996)

55.  Suzuki T, Okumura-Noji K: NMDA receptor subunits epsilon 1 (NR2A) and epsilon 2 (NR2B) are substrates for Fyn in the postsynaptic density fraction isolated from the rat brain. Biochem. Biophys. Res. Commun. 210: 582-588 (1995)

56.  Wang YT, Salter MW: Regulation of NMDA receptors by tyrosine kinases and phosphatases. Nature 369: 233-235 (1994)

57.  Wang YT, Yu X, Salter MW: Ca(²⁺)-independent reduction of N-methyl-D-aspartate channel activity by protein tyrosine phosphatase. Proc. Natl. Acad. Sci. USA 93: 1721-1725 (1996)

58.  Hall RA, Soderling TR: Differential surface expression and phosphorylation of the N-methyl-D-aspartate receptor subunits NR1 and NR2 in cultured hippocampal neurons. J. Biol. Chem. 272: 4135-4140 (1997)

59.  Rao A, Craig AM: Activity regulates the synaptic localization of the NMDA receptor in hippocampal neurons. Neuron 19: 801-812 (1997)

60.  Nagy LE, Diamond I, Collier K et al: Adenosine is required for ethanol-induced heterologous desensitization. Mol. Pharmacol. 36: 744-748 (1989)

61.  Brennan CH, Lewis A, Littleton JM: Membrane receptors, involved in up-regulation of calcium channels in bovine adrenal chromaffin cells, chronically exposed to ethanol. Neuropharmacology 28: 1303-1307 (1989)

62.  Harper JC, Brennan CH, Littleton JM: Genetic up- regulation of calcium channels in a cellular model of ethanol dependence. Neuropharmacology 28: 1299-1302 (1989)

63.  Littleton JM: Calcium channel activity in alcohol dependency and withdrawal seizures. In Porter RJ, Mattson RH, Cramer JA, Diamond I (Eds): Alcohol and Seizures: Basic mechanisms and clinical concepts .Philadelphia, Davis, pg 51-67, 1990

64.  Wright JM, Peoples RW, Weight FF: Single channel and whole-cell analysis of ethanol inhibition of NMDA-activated currents in cultured mouse cortical and hippocampal neurons. Brain Res. 738: 249-256 (1996)

65.  Whittington MA, Lambert JD, Little HJ: Increased NMDA and calcium channel activity underlying ethanol withdrawal hyperexcitability. Alcohol Alcohol. 30: 105-114 (1995)

66.  Traynelis SF and Cull CSG: Proton inhibition of N-methyl-D-aspartate receptors in cerebellar neurons. Nature 345: 347-50 (1990)

67.  Schuckit MA: Alcohol and alcoholism. In: Harrison’s Principles of Internal Medicine (14^th ed.), Fauci AS et al., (editors), pp 2503-2508. McGraw-Hill, New York, 1998

68.  Everitt BJ, Morris KA, O’Brien A, Robbins TW: The basolateral amygdala-ventral striatal system and conditioned place preference: further evidence of limbic-striatal interactions underlying reward-related processes. Neuroscience 42: 1-18 (1991)

69.  Dunn LT, Everitt BJ: Double dissociations of the effects of amygdala and insular cortex lesions on conditioned taste aversion, passive avoidance, and neophobia in the rat using the excitotoxin ibotenic acid. Behav. Neurosci. 102: 3-23(1988)

70.  Barbaccia ML, Bosio PF, et al: Ethanol metabolism and striatal dopamine systems. Pharmacol Biochem. Behav. 18 (Suppl I): 169-177 (1982)

71.  White NM: Addictive drugs as reinforcers: multiple partial actions on memory systems. Addiction 91: 921-949 (1996)

72.  Estes WK: Cognitive architectures from the standpoint of an experimental psychologist. Annu. Rev. Psychol. 42: 1-28 (1991)

73.  Butters N, Martone M, et al: Clinical validators: comparisons of demented and amnesic patients. In: Pool L (ed) Handbook of clinical assessment of memory, APA, Washington, pp. 337-352 (1986)

74.  Prado-Alcala RA: Is cholinergic activity of the caudate nucleus involved in memory? Life Sci. 37: 2135-2142 (1985)

75.  Jope RJ, Jenden DJ: Effects of acute ethanol treatment on cholinergic functions in rats. Subst. Alcohol Actions/Misuses 2: 15-23 (1981)

76.  Gill K, France C, Amit Z: Voluntary ethanol consumption in rats: an examination of blood/brain ethanol levels and behavior. Alcohol Clin. Exp. Res. 10: 457-562 (1986)

77.  Samson HH, Haraguchi M, et al: Antagonism of ethanol-reinforced behavior by the benzodiazepine inverse agonist Ro 15-4513 and Fg 7142: Relation to sucrose reinforcement. Pharmacol Biochem. Behav. 32: 601-608 (1989)

78.  George FR: Genetic models for the study of alcoholism and substance abuse mechanisms. Progr. Neuropsychopharmacol. Biol. Psychiatry 17: 345-361 (1993)

79.  Amit Z, Smith BR: Differential ethanol intake in Tryon maze-bright and Tryon maze-dull rats: implication for the validity of the animal model of selectively bred rats for high ethanol consumption. Psychopharmacology 108: 136-140 (1992)

80.  Volpicelli JR, Alterman Al, Hayashida M: Naltrexone in the treatment of alcohol dependence. Arch. Gen. Psychiatry 42: 876-880 (1992)

81.  O’Malley SS, Jaffe AJ, Chang G, Schottenfeld RS, Meyer RE, Rounsaville BJ: Naltrexone and coping skills therapy for alcohol dependence: a controlled study. Arch. Gen. Psychiatry 42: 881-887 (1992)

82.  Volpicelli JR, Rhines KC, Rhines JS, Volpicelli LA, Alterman Al, O’Brien CP: Naltrexone and alcohol dependence: Role of subject compliance. Arch. Gen. Psychiatry 54: 737-742 (1997)

83.  Sass H, Soyka M, Mann K, Zieglgaensberger W: Relapse prevention by acamprosate. Arch. Gen. Psychiatry 53: 673-680 (1996)

84.  Kaplan HI, Saddock BJ: Synopsis of psychiatry: behavioral sciences, clinical psychiatry (8^th ed.) Williams and Wilkins, Baltimore (1998)

85.  Butterworth RF: Pathophysiology of alcoholic brain damage: synergistic effects of ethanol, thiamine deficiency and alcoholic liver disease. Metab. Brain Dis. 6: 207-212 (1995)

86.  Mills PR, Shenkin A, Anthony RS, et al: Assessment of nutritional status and in vivo immune responses in alcoholic liver disease. Am. J. Clin. Nutr. 38: 849-859 (1983)

87.  Neville JN, Eagles JA, Samson G and Olson RE: Nutritional status of alcoholics. Am. J. Clin. Nutr. 21: 1329-1340 (1968)

88.  Thomson AD, Baker H, Leevy CH: Patterns of 35 S- thiamine hydrochloride absorption in the malnourished alcoholic patient. J. Lab. Clin Med. 76: 34-45 (1970)

89.  Breen KJ, Buttigieg R, Iossifidis S, et al: Jejunal uptake of thiamin hydrochloride in man: influence of alcoholism and alcohol. Am. J. Clin. Nutr. 42: 121-126 (1985)

90.  Hoyumpa AM Jr, Breen KJ, Schenker S, Wilson FA: Thiamine trasport across the rat intestine. II. Effect of ethanol. J. Lab. Clin. Med. 86: 803-816 (1975)

91.  Hoyumpa AM Jr, Nichols SG, Wilson FA, Schenker S: Effect of ethanol on intestinal (Na,K) ATPase and intestinal thiamine trasport in rats. J. Lab. Clin. Med. 92: 1086-1095 (1977)

92.  Shaw S, Gorkin BD, Lieber CS: Effects of chronic alcohol feeding on thiamin status: biochemical and neurological correlates. Am. J. Clin. Nutr. 34: 856-860 (1981)

93.  Inokuchi T, Inoue K, Aoyama A, Hashizume N: Effect of ethanol ingestion on thiamine metabolism: Clinical and experimental studies. J. Nutr. Sci. Vitaminol. 27: 263-281 (1981)

94.  Camilo ME, Morgan MY, Sherlock S: Erythrocyte transketolase activity in alcoholic liver disease. Scand. J. Gas-troenterol. 10: 273-279 (1981)

95.  Rindi G, Comincioli V, Reggiani C, Patrini C: Nervous tissue thiamine metabolism in vivo, III. Influence of ethanol intake on the dynamics of thiamine and its phosphoesters in different brain regions and sciatic nerve of the rat. Brain Res. 413: 23-25 (1987)

96.  Hrubec Z, Omenn GS: Evidence of genetic predisposition to alcoholic cirrhosis and psychosis. Twin concordances for alcoholism and its biological end points by zygosity among male veterans. Alcohol. Clin. Exp. Res. 5: 207-215 (1981)

97.  Blass JP, and Gibson GE: Abnormality of a thiamine requiring enzyme in patients with Wernicke-Korsakoff syndrome. N. Engl. J. Med. 297: 1367-1370 (1977)

98.  Lindboe CF, Loberg EM: Wernicke’s encephalopathy in non-alcoholics. An autopsy study. J. Neurol. Sci. 90: 125-129 (1989)

99.  Fadda F, Rossetti ZL: Chronic ethanol consumption: From neuroadaptation to neurodegeneration. Prog. Neurobiol. 50: 385-431 (1998)

100. Langlais PJ: Pathogenesis of diencephalic lesion in an experimental model of Wernicke’s encephalopathy. Metab. Brain Dis. 10: 31-44 (1995)

101. Zhang SX, Weilersbacher GS, et al: Excitotoxic cytopathology, progression, and reversibility of thiamine deficiency induced diencephalic lesions. J. Neuropathol. Exp. Neurol. 54: 255-267 (1995)

102. Yang X, Criswell H, et al: Evidence for a selective effect of ethanol of N-methyl-D-aspartate responces: ethanol affects subtype of the ifenprodil-sensitive N-methyl-D-aspartate receptors. J. Pharmacol. Exp. Ther. 278: 114- 124 (1996)

103. Collins M, Corso TD, Nealsey EJ: Neuronal degeneration in rat cerebrocortical and olfactory regions during subchronic ’binge’ intoxication with ethanol: possible ex-planation for olfactory deficits in alcoholics. Alcohol Clin. Exp. Res. 20: 284-292, (1996)

104. Kato K, Puttfarcken PS, Lyons WE, Coyle JT: Developmental time course and ionic dependence of kainate-mediated toxicity in rat cerebellar granule cell cultures. J. Pharmacol. Exp. Ther. 250: 402-411 (1991)

105. Choi D: Glutamate neurotoxicity and diseases of the nervous system. Neuron 1: 623-634 (1988)

106. Baker H, Frank O: Absorption, utilization and clinical effectiveness of allithiamines compared to water-soluble thiamines. J. Nutr. Sci. Vitaminol. 22 (Suppl): 63-68 (1976).

107. Committee on Safety of Medicines: Parentrovite and allergic reactions. Curr. Probl. 24: 1 (1989)

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