Τόμος 14 (2000) – Τεύχος 3 – Άρθρο 1 – Επιθεώρηση Κλινικής Φαρμακολογίας και Φαρμακοκινητικής-Διεθνής Έκδοση – Volume 14 (2000) – Issue 3 – Article 1 – Epitheorese Klinikes Farmakologias και Farmakokinetikes-International Edition

Title Topical and systemic therapeutic management of acne
Authors Vassiliki Kefala¹ and Stavros T. Plessas²

1.       Technological Educational Institution of Athens, Athens, Greece

2.      Department of Nursing, University of Athens, Athens, Greece

Citation Kefala, V., Plessas, S.T: Topical and systemic therapeutic management of acne, Epitheorese Klin. Farmakol. Farmakokinet. 14(3): 101-110 (2000)
Publication Date Received for publication: 1 April 2000

Accepted for publication: 20 June 2000

Full Text Language English
Order – Buy  Ηλεκτρονική Μορφή: pdf (10 €) – Digital Type: pdf (10 €)

pharmakonpress[at]pharmakonpress[.]gr

Keywords Acne vulgaris, comedonal acne, minocycline hydrochloride, antiandrogens, isotretinoin.
Other Terms review article
Summary Acne is a very common skin disorder affecting an important number of people, mainly teenagers. The following are believed to be the factors in its production: the obstruction of the sebaceous gland due to the impairment of the keratinisation, the seborrhea, the increase in the level of the circulating androgens, the presence of microbes. Different therapeutic treatments have been suggested and are being applied, although no specific treatment has ever been established. The topical pharmaceutical treatment includes desquamative substances, retinoic acid, benzoyl peroxide, antimicrobic drugs, corticosteroids, and antiseptics. The systemically administered treatments include antibiotics, estrogens, oral contraceptives, glucocorticosteroids, gonadotropin-reteasing hormone agonists, antiandrogens, isotretinoin. The symptomatic treatment of acne using mechanical, chemical and natural methods include extraction of comedones, use of galvanic currents, use of high frequency currents, massage, mask application, a hydrating product, peeling application, UV radiation.
References 1.    Landow K.: Dispelling myths about acne. Postgrad Med. 102: 94-99, 103-104, 110-112 (1997)

2.    Gallen B.A.: Acne vulgaris. Lippincotts Prim. Care Pract. 7: 88-92(1997)

3.    Jansen T., Burgdorf W.H., Piewing G.: Pathogenesis and treatment of acne in childhood. Pediatr. Dermatol. 14: 17-21 (1997)

4.    Brown S.K., Shalita A.R.: Acne vulgaris. Lancet. 351: 1871-1876 (1998)

5.    Jansen T., Piewing G.: Advances and perspectives in acne therapy. Eur. J. Med. Res. 2: 321-334 (1997)

6.    Stathakis V., Kilkenny M., Marks R.: Descriptive epidemiology of acne vulgaris in the community. Australas J. Dermatol. 38: 115-123 (1997)

7.    Faure M.: Acne. Etiology, physiopathology, diagnosis, treatment. Rev. Prat. 46: 887-892 (1996)

8.    Black P.A.: Acne vulgaris. Prof. Nurse. 11: 181-183 (1995)

9.    Webster G.F.: Inflammation in acne vulgaris. J. Am. Acad. Dermatol. 33: 247-253 (1995)

10.  Rothman K.F., Lucky A.W.: Acne vulgaris. Adv. Dermatol. 8: 347-374 (1993)

11.  Faure M.: Acne. Etiology, physiopathology, diagnosis, treatment. Rev. Prat. 43: 1301-1305 (1993)

12.  Janniger C.K.: Neonatal and infantile acne vulgaris. Cutis 52: 16 (1993)

13.  Rossen M.H., Roed Petersen J.: Acne vulgaris. Ugerskr. Laeger. 155: 775-778 (1993)

14.  Matsuoka L.Y.: Acne and related disorders, Clin. Plast. Surg. 20: 35-41 (1993)

15.  Millikan L.E., Shrum J.P.: An update on common skin diseases. Acne, psoriasis, contact dermatitis and warts. Postgrad. Med. 91: 96-98, 101-104, 107-110 (1992)

16.  Sehgal V.N., Jain S.: Acne and acneiform dermatoses. J. Indian. Med. Assoc. 89: 80-81 (1991)

17.  Kligman A.M.: Postmenopausal acne. Cutis 47: 425- 426(1991)

18.  Leung A.K., Robson W.L.: Acne. J.R. Soc. Health. 712: 57-60(1991)

19.  Webster G.F.: Inflammatory acne. Int. J. Dermatol. 29: 317-319 (1990)

20.  Amblard P.: Acne. Physiopathology, clinical aspects, treatment. Rev. Prat. 40: 662-664 (1990)

21.  Leyden J.J.: New understandings of pathogenesis of acne. J. Am. Acad. Dermatol. 32: 15-25 (1995)

22.  Gollnick H., Schramm M.: Topical therapy in acne. J. Eur. Acad. Dermatol. Venereol. 11: 8-12 (1998)

23.  Van Hoogdalem E.J.: Transdermal absorption of topical anti-acne agents in man; review of clinical pharmacokinetic data. J. Eur. Acad. Dermatol. Venereol. 11: 13-19 (1998)

24.  Cunliffe W.J.; Management of adult acne and acne variants. J. Cutan. Med. Surg. 2: 7-13 (1998)

25.  Marcoux D., Mc Cuaig C.C., Powell J.: Prepubertal acne: clinical presentation, evaluation and treatment. J. Cutan. Med. Surg. 2: 2-6 (1998)

26.  Miller R.A.: Side effects of acne therapy and their management. J. Cutan. Med. Surg. 2: 14-18 (1998)

27.  De Grood H.E., Friedlander S.F.: Update on acne. Curr. Opin. Pediatr. 10: 381-386 (1998)

28.  Boston M.: Acne: avoiding permanent damage. Com-munity Nurse 3: 15-16 (1997)

29.  Leyden J.J.: Topical treatment of acne vulgaris: retinoids and cutaneous irritation. J. Am. Acad. Dermatol. 38: 1-4 (1998)

30.  Usatine R.P., Qluan M.A., Strick R.: Acne vulgaris: a treatment update. Hosp. Pract. Off. Ed. 33:111-117, 121- 124, 127(1998)

31.  Schmidt J.B., Fanta D.: 13 – cis retinoic acid an effective therapy for acne conglobata. 2. Hautkr. 59: 279-287 (1984)

32.  Gibson J.R.: Rationale for development of new topical treatments for acne vulgaris. Cutis 57: 13-19 (1996)

33.  Berson D.S., Shalita A.R.: The treatment of acne: the role of combination therapies. J. Am. Acad. Dermatol. 32: 31-41 (1995)

34.  Webster G.F.: Topical tretinoin in acne therapy. J. Am. Acad. Dermatol. 39: 38-48 (1998)

35.  Schmidt J.B., Neumann R., Fanta D., Raab W. 1 sent per clindamycin phosphate solution versus 5 per cent benzoyl peroxide gel in papulopustular acne. Z Hautkr. 63: 374-376 (1988)

36.  Fanta D., Muller M.M.: Effect of benzoyl peroxide on skin surface lipids. Dermatogica 158: 55-59 (1979)

37.  Webster G.F.: Inflammation in acne vulgaris. J. Am. Acad. Dermatol. 33: 247-253 (1995)

38.  Munro C.S.: Acne. J.R. Coll. Physicians. Lond. 31: 360-363 (1997)

39.  O’ Loughlin S.: Treatment of acne. Ir. Med. J. 88: 114- 115 (1995)

40.  Fanta D., Scholz N.: Miconazol – Benzoyl peroxid: eine neue kombination zur Erweiterung der lokalen Aknetherapie. Z Hautkr. 59: 873-881 (1984)

41.  Weiss J.S.: Current options for topical treatment of acne vulgaris. Pediatr. Dermatol. 14: 480-488 (1997)

42.  Weiss J.S., Shavin J.S.: Adapatene for treatment of acne vulgaris. J. Am. Acad. Dermatol. 39: 50-54 (1998)

43.  Gibson J.R.: Azelaic acid 20% cream and the medical management of acne. Dermatol. Nurs. 9: 339-344 (1997)

44.  Solomon B.A., Shalita A.R.: Effects of detergents on acne. Clin. Dermatol. 14: 95-99 (1996)

45.  Mackrides P.S., Shaughnessy A.F.: Azelaic acid therapy for acne. Am. Fam. Physician. 54: 2457-2459 (1996)

46.  Nguyen Q. H., Bui T.P.: Azelaic acid: pharmakokinetic and pharmacodynamic properties and its therapeutic role in hyperpigmentary disorders and acne. Int. J. Dermatol. 34: 75-84 (1995)

47.  Gibson J.R.: Benzamycin gel for acne. Drug. Then Bull. 33: 62-64 (1995)

48.  Cooper A.J.: Systemic review of Propionibacterium acnes resistance to systemic autibiotics. Med. J. Aust. 169: 259-261 (1998)

49.  Taffe A.M.: Acne treatment. A comprehensive review of pharmacotherapy. Lippincotts. Prim. Care. Pract. 1: 70- 87 (1997)

50.  Brogden R.N., Goa K.E.: Adapalene. A review of its pharmacological properties and clinical potential in the management of mild to moderate acne. Drugs 53: 511-519 (1997)

51.  Leyden J.J.: Therapy for acne vulgaris. N. Engl. J. Med. 336: 1156-1162 (1997)

52.  Parry E.J., Griffiths C.E.: Bacteria and antimicrobial agents in the treatment of acne. Int. J. Dermatol. 35: 249- 251 (1996)

53.  Thiboutot D.M.: An overview of acne and its treatment. Cutis 57: 8-12 (1996)

54.  Lee A.G.: Pseudotumor celebri after treatment with tetracycline and isotretinoin for acne. Cutis 55: 165-168 (1995)

55.  Fanta D.: Clinical experiences with a new erythromycin – containing externally administered drug for treatment of acne. Z Hautkr. 55: 1528-1531 (1980)

56.  Redmond G.P.: Effectiveness of contraceptives in the treatment of acne. Contraception 58: 29-33 (1998)

57.  Cunliffe W.J.: Hormonal therapy for acne in women. J. Pediatr. Adolesc. Gynecol. 11: 157-159 (1998)

58.  Beylot C., Doutre M.S., Beylot – Barry M.: Oral contraceptives and cyproterone acetate in female acne treatment. Dermatology 196: 148-152 (1998)

59.  Baur D.A., Butler R.C.: Current concepts in the pathogenesis and treatment of acne. J. Oral. Maxillofac. Surg. 56: 651-655 (1998)

60.  Shaw J.C.: Antiandrogen and hormonal treatment of acne. Dermatol. Clin. 14: 803-811 (1996)

61.  Fanta D., Muller M.M.: Effect of cyproterone acetate on skin surface lipids. Acta Derm. Venereol. 58: 85-87 (1978).

62.  Fanta D., Schneider W.H., Spona J., Neufeld T.: Anti androgen treatment of acne. Wien. Klein. Wochenchr. 89: 622-627 (1977)

63.  Fanta D., Stoger H.: Hormonal therapy of acne vulgaris. Review and results of treatment. Wien. Klin. Wochenschr. 87: 158-163 (1975)

64.  Goodfellow A. et Al: Oral spironolactone improves acne vulgaris and reduces sebum excretion. Br. J. Dermatol. 111: 209 (1984)

65.  Cusan L. et al.: Treatment of hirsutism with pure andiandrogen flutamide. J. Am. Acad. Dermatol. 23: 462 (1990)

66.  Chen W. et al.: The 5-alpha reductase system and its inhibitors: Recent development and its perspective in treating androgen-dependent skin disorders. Dermatology 193: 177(1996)

67.  Leyden J.J.: The role of isotretinoin in the treatment of acne: personal observations. J. Am. Acad. Dermatol. 39: 45-49 (1998)

68.  Coates, P., Adams C.A., Cunliffe W.J., Me Ginley K.T., Eady E.A., Leyden J.J., Ravenscroft J., Vyakrnam S., Vowels B.: Does oral isotretinoin prevent Propionibacterium acnes resistance? Dermatology 195: 4-9 (1997)

69.  Leyden J.J.: Oral isotretinoin. How can we treat difficult acne patients? Dermatology 195: 29-33 (1997)

70.  Horne H.L., Carmichael A.J.: Juvenile nodulocystic acne responding to systemic isotretinoin. Br. J. Dermatol. 136: 796-797(1997)

71.  Schmidt J.B., Fanta D.: 13 – cis retinoic acid an effective therapy for acne conglobata. Z Hautkr. 59: 279-287 (1984)

72.  Bertolucci L.E.: Introduction of any inflammatory drugs byiontoforesis: G. Ortho. Phys. Therap. 4: 104 (1982)

73.  Williams D.F. and Schmitt W.H.: Chemistry and Technology of the Cosmetics and Toiletries Industry. Chapman and Hall, London (1996)

74.  Wiecher J.W., Barlow T.: Skin moisturisation and elasticity originate from at least two different mechanisms. Int. J. Cosmet. Sci. 21: 425-435 (1999)

75.  Russo T., Landeryou V., Hall L.: Polyglycerol Esters, a new class of active skin moisturisers. Cosm. and Toil. Wld. 25: 142-148(1997)

76.  Chersetich I., Teofoli P., Gantcheva M., Ribuffo M., Puddu P.: Chemical peeling: how, when, why? J. Eur. Acad. Dermatol. 8: 1-11 (1997)

77.  Bridenstine J.B., Dolezal J.F.: Standardizing chemical peel solution formulations to avoid mishaps. J. Dermatol Surg. Oncol. 20: 813-816 (1994)

78.  Glogan RG., Matarasso SL.: Chemical peels. Dermatol. Clin. 13: 263-265 (1995)

79.  Abel E.A.: Phototherapy. Dermatol. Clin. 13: (4) 841- 849 (1995)

80.  Gilchrest B.A.: Mechanisms of ultraviolet light-induced pigmentation. Photochem. Photobiol. 63: 1 (1996)

81.  Taylor C.R., Stem R.S., Leyden J.T., GNcherst B.A.: Photoaging, photodamage and photoprotection. J. Am. Acad. Dermatol. 22: 1-15 (1990)

82.  Barlow T., Wiechers, J.W. Measuring skin hydration. Cosm. Toil. 114: 47-53 (1999)

Relative Papers

Online ISSN 1011-6575

Άρθρα Δημοσιευμένα σε αυτό το Περιοδικό Καταχωρούνται στα:

Articles published in this Journal are Indexed or Abstracted in: • Chemical Abstracts • Elsevier’s Bibliographic Databases: Scopus, EMBASE, EMBiology, Elsevier BIOBASE SCImago Journal and Country Rank Factor

Τι είναι η Επιθεώρηση Κλινικής Φαρμακολογίας και Φαρμακοκινητικής-Διεθνής Έκδοση-Οδηγίες προς τους Συγγραφείς – 
What is Epitheorese Klinikes Farmakologias 
και Farmakokinetikes-International Edition-Instrunctions to Authors

Άρθρα Δημοσιευμένα στην Επιθεώρηση Κλινικής Φαρμακολογίας και Φαρμακοκινητικής-Διεθνής Έκδοση – 
Articles Published in Epitheorese Klinikes Farmakologias 
και Farmakokinetikes-International Edition

Συντακτικη Επιτροπή-Editorial Board

ΕΤΗΣΙΑ ΣΥΝΔΡΟΜΗ 2000 – ANNUAL SUBSCRIPTION 2000
Γλώσσα Πλήρους Κειμένου – Full Text Language Αγγλικά – English
Παραγγελία – Αγορά – Order – Buy Ηλεκτρονική Μορφή: pdf (70 €) – Digital Type: pdf (70 €)

pharmakonpress[at]pharmakonpress[.]gr

Έντυπη Μορφή (70 € + έξοδα αποστολής) – Printed Type (70 € + shipping)

pharmakonpress[at]pharmakonpress[.]gr

 

 

 

Bookmark the permalink.

Comments are closed.