| Title | The influence of olive oil diet on atherogenic factors in rats | |
| Authors | N. Kazanas, A. Potamianou, C. Gourna, I. Nikolidakis and C. Tesserommatis
Department of Experimental Pharmacology, Medical School, University of Athens, Greece, Goudi 11527 |
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| Citation | Kazanas, N., Potamianou, A., Gourna, C., Nikolidakis, I., Tesserommatis, C.: The influence of olive oil diet on atherogenic factors in rats, England and Wales: the smoking case study, Epitheorese Klin. Farmakol. Farmakokinet. 14(3): 131-144 (2000) | |
| Publication Date | Received for publication: 25 June 2000
Accepted for publication: 20 August 2000 |
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| Full Text Language | English | |
| Order – Buy | Ηλεκτρονική Μορφή: pdf (10 €) – Digital Type: pdf (10 €)
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| Keywords | Atherosclerosis, cytokine, endothelium, olive oil, oxidation, rats. | |
| Other Terms | review article | |
| Summary | The vascular endothelium is related to the pathogenesis of cardiovascular diseases by the mediation of cytokines, which activate the adhesion of neutrophiles and eosinophiles in endothelial cells. The loss of endothelium integrity during the chronic inflammatory changes of the atheromatic disease is reflected on the elevation of the cytokine levels in plasma. Besides cholesterol, the elevation of plasma fibrinogen levels is well established as risk factor for cardiovascular disease. In this study, the protective role of olive oil diet in relation to the mechanism of endothelium dysfunction is investigated via the changes of fibrinogen, antithrobin- III, cholesterol and cytokines (IL-1a, IL-6, IL-8, TNFa). A detectable amelioration of the high-risk parameters of the atheromatic disease development is observed after consumption of olive oil, while the opposite is noted on the cytokine levels. The defensive role of the olive oil on the progression of lesions of the vascular endothelium and the thrombotic complications during the atherogenetic process might be owed to the activation of immune responses, mediated by the cytokines, but a further investigation of the oxidative and coagulation events is needed. | |
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Online ISSN 1011-6575
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