Τόμος 15 (2001) – Τεύχος 1 – Άρθρο 3 – Επιθεώρηση Κλινικής Φαρμακολογίας και Φαρμακοκινητικής-Διεθνής Έκδοση – Volume 15 (2001) – Issue 1 – Article 3 – Epitheorese Klinikes Farmakologias και Farmakokinetikes-International Edition

Title Licit substance abuse during pregnancy and its effect on the foetus
Authors Anna Deltsidou¹, Katerina Lykeridou² and Stavros T. Plessas³

1.       Alexandra General Hospital, Athens, Greece

2.      Technological Educational Institution of Athens, Egaleo, Athens, Greece

3.      Department of Nursing, University of Athens, Athens, Greece

Citation Deltsidou, A., Lykeridou, K., Plessas, S.T.: Licit substance abuse during pregnancy and its effect on the foetus, Epitheorese Klin. Farmakol. Farmakokinet. 15(1): 21-32 (2001)
Publication Date Received for publication: 5 November 2000

Accepted for publication: 25 November 2000

Full Text Language English
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Keywords Addiction, dependence, withdrawal syndrome, fetal alcohol syndrome FAS syndrome, substance abuse.
Other Terms review article
Summary Subject of this literature review is the impact of licit psychoactive substance abuse during pregnancy and their long-term consequences on the foetus. These psychoactive substances can be grouped into two categories: (a) licit substances, including alcohol, tobacco, caffeine and inhalants and (b) illicit drugs, including cannabis, opioids, cocaine, hallucinogens, amphetamines and hypnotic or anxiolytic drugs. Because of its importance in understanding the different ways, a substance may an effect on the foetus, a short description was given about how foetal substance exposure relates to maternal substance concentration, the placental permeability and the mechanisms of placental transfer and the role of the foetus in determining foetal concentrations. It follows the description of the characteristics of each one of the abused licit substances during pregnancy and their adverse effects on the foetus. Epidemiological data of several surveys, since 1988, were discussed. Prenatal exposure to alcohol is associated with the Fetal Alcohol Syndrome (FAS) and with mental retardation and other neurodevelopmental disorders of the infant, which are the most devastating results of maternal alcohol abuse during pregnancy. Cigarette smoking during pregnancy has been associated with a lower birth weight and a delay in postnatal growth of the neonates. A few of the children born to solvent abusing mothers have craniofacial abnormalities like those seen in children with the Fetal Alcohol Syndrome (FAS). Finally, several studies in humans have shown that caffeine is safe when ingested in customary amounts during pregnancy. In conclusion, these social and recreational substances, singly or together, may cause defects on the foetus and the neonate, with those effects extending into adulthood. The use of licit substances during pregnancy remains a major health problem, which demands specific measures to be confronted.
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