| Title | Sodium-hydrogen exchanger (NHE) inhibition: a new therapeutic approach for ischemic heart disease | |
| Authors | C.E. Papadopoulos, H.I. Karvounis and G.E. Louridas
1st Department of Cardiology, Aristotle University of Thessaloniki, AHEPA Hospital, Thessaloniki, GREECE |
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| Citation | Papadopoulos, C.E., Karvounis, H.I.., Louridas, G.E.: Sodium-hydrogen exchanger (NHE) inhibition: a new therapeutic approach for ischemic heart disease, Epitheorese Klin. Farmakol. Farmakokinet. 15(2): 61-68 (2001) | |
| Publication Date | Received for publication: 2 March 2001
Accepted for publication: 20 March 2001 |
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| Full Text Language | English | |
| Order – Buy | Ηλεκτρονική Μορφή: pdf (10 €) – Digital Type: pdf (10 €)
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| Keywords | Sodium-hydrogen exchanger, myocardial cell, ischemia, metabolism, sodium-hydrogen exchanger inhibitors, cardioprotection. | |
| Other Terms | review article | |
| Summary | Sodium-Hydrogen Exchanger (NHE), an antiporter system exchanging sodium and hydrogen ions across cell membrane in the majority of eukaryotic cells, plays a pivotal role in the regulation of intracellular pH and thus protect the cell from stimuli producing acidification and evolving death. This article, reviews all the up to date data, concerning this novel cell pump. It takes into consideration its structural features, summarizes the regulation and the effect of this antiport on intracellular ions metabolism and its effect on intracellular pH regulation and cell metabolism. It also describes a new class of drugs, the so called sodium hydrogen exchanger inhibitors, which seem to exert considerable cardioprotective effects, by inhibiting NHE function thus reducing detrimental calcium overload (amiloride and cariporide being the most important and excessively studied representatives). It is finally seeking into clinical potential and clinical implications of these drugs, concerning major cardiovascular priorities such as acute coronary syndromes, myocardial infarction, PTCA, cardiac surgery and transplantation. | |
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Online ISSN 1011-6575
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