| Title | The influence of antioxidant agents on lipidaemic profile of stressed rats | |
| Authors | Antonia Kotsiou², Angeliki Potamianou³, Joanna Messari¹ and Christine Tesseromatis¹
1. Department of Pharmacology, Medical School, University of Athens, Athens, Hellas 2. Aretaieion University Hospital, Athens, Hellas 3. General hospital Asclepeion, Voula, Athens, Hellas |
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| Citation | Kotsiou, A., Potamianou, A., Messari, J., Tesseromatis, C.: The influence of antioxidant agents on lipidaemic profile of stressed rats, Epitheorese Klin. Farmakol. Farmakokinet. 21(1): : 31-37 (2007) | |
| Publication Date | Accepted for publication (Final version): 15 January 2007 | |
| Full Text Language | English | |
| Order – Buy | Ηλεκτρονική Μορφή: pdf (10 €) – Digital Type: pdf (10 €)
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| Keywords | Swimming stress, serum lipids, antioxidants, olive oil. | |
| Other Terms | review article | |
| Summary | Stress is the result of physical or emotional stimuli on the organism creating positive or negative response, which may cause damages to all systems by altering their physiology. Stress influences the serum lipid parameters leading to cardiovascular diseases. In the industrial world, stress and saturated lipid nutrition potentiate the development of atherosclerosis. Among the lipid profile disorders, the oxidized LDL-lipoproteins are the most responsible for atherosclerotic lesions. Many data demonstrate that the administration of antioxidant agents may have a protective and preventive effect against the cardiovascular disease. The aim of the study was to compare the role of some antioxidants, such as vitamins E and C, and food rich in olive oil, on the lipid profile of cold water stressed rats. Two groups of Wistar rats (b.w. 240±10 g) were used A group (control) and B group (swimming stress). Each group was divided into four subgroups (n=7): A1, B1 (control) – A2, B2 received vitamin E 4.2 mg/kg – A3, B3 received vitamin C 42 mg/kg – A4, B4 were fed with a mixture of 40% olive oil and cereals. Animals were sacrificed by decapitation after 20 days. Cold swimming stress decreased the total cholesterol TC, triglycerides TG and HDL levels (B1/A1 group), while the atheroma index TC/HDL rised. Vitamins E and C seem to affect positively the lipid parameters, but the consumption of olive oil mixture ameliorated the lipid parameters to the normal values despite stress. It may be concluded that cold exerts intensive effects on lipid profile and that the antioxidants but especially the diet rich in olive oil reduces successfully the risk of atherosclerotic damages. | |
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