| Title | Telithromycin and hepatotoxicity: a case report and a literature review | |
| Authors | P. Aggelopoulou¹, A. Kapatais¹, N. Souvaliotis¹, D. Soufleris¹, G. Moutsokos¹, and S. Chrysou²
1. First Department of Pathology, General Hospital of West Attika, Aigaleo, Athens,Greece 2. Department of Microbiology, General Hospital of West Attika, Aigaleo, Athens,Greece |
|
| Citation | Aggelopoulou, P., Kapatais, A., Souvaliotis, N., Soufleris, D., Moutsokos. G. et al: Telithromycin and hepatotoxicity: a case report and a literature review, Epitheorese Klin. Farmakol. Farmakokinet. 21(3): 293-295 (2007) | |
| Publication Date | Accepted for publication (Final version): September 10, 2007 | |
| Full Text Language | English | |
| Order – Buy | Ηλεκτρονική Μορφή: pdf (10 €) – Digital Type: pdf (10 €)
pharmakonpress[at]pharmakonpress[.]gr |
|
| Keywords | Acute hepatitis, telithromycin, antibiotic drugs. | |
| Other Terms | review article | |
| Summary | In this paper it is described 1 case of hepatotoxicity in a 65 year-old white woman patient who had recently taken telithromycin for sinusitis. The patient was admitted to the hospital because of anorexia fatigue and fever. In our case the patient had no history of alcohol use or any other concomitant liver disease. A liver biopsy was per- formed and the histologic findings were as follow: alterations compatible to acute hepatitis, with advanced necrosis. The presence of eosinophils and the absence of significant portal inflammation is a sign of pharmaceutical hepatitis. The medications that the patient was taking (A-MEA and multivitamins) hadn’t cause to her any adverse effect from the beginning of their use. The withdrawal of Telithromycin led to the clinical improvement of the patient. The patient after a few days recovered. | |
| References | 1. Product information: Ketek [Telithromycin]. Kansas City, MO; Aventis Pharamaceuticals Inc.; October 2004
2. Larrey D., Pageaux G.P.: Drug-induced acute liver failure. Eur. J. Gastenerol. Hepatol. 17: 141-143 (2005) 3. Maddrey W.C.: Drug-induced hepatotoxicity: 2005. J. Clin. Gastrenterol. 39: S83-89 (2005) 4. U.S. Food and Drug Administration Center for Drug Evaluation and Research. The Adverse Event Reporting System (AERS) 5. Kanathur N., Mathai M.G., Byrd R.P.,Jr, FieIds C.L., Roy T.M.: Simvastastin-diltiazem drug interaction resulting in rhabdomyolysis and hepatitis. Tenn. Med. 94: 339-341 (2001) 6. Dourakis S.P.: Clinical Hepatology 7. Clay K.D., Hanson J.S., Pope S.D., Rissmiler R.W., Purdum P.P., M.Banks P.M.: Severe hepatotoxicity of telithromycin: Three case reports and literature review. Ann. Intern. Med. 144 (6): (2006) 8. Nilesh Mehta: Drug-Induced Hepatotoxicity. eMedicine |
|
| Relative Papers |
Online ISSN 1011-6575
Άρθρα Δημοσιευμένα σε αυτό το Περιοδικό Καταχωρούνται στα:
- Chemical Abstracts
- Elsevier’s Bibliographic Databases: Scopus, EMBASE, EMBiology, Elsevier BIOBASE SCImago Journal and Country Rank Factor
Articles published in this Journal are Indexed or Abstracted in: • Chemical Abstracts • Elsevier’s Bibliographic Databases: Scopus, EMBASE, EMBiology, Elsevier BIOBASE SCImago Journal and Country Rank Factor
Συντακτικη Επιτροπή-Editorial Board
| ΕΤΗΣΙΑ ΣΥΝΔΡΟΜΗ 2007 – ANNUAL SUBSCRIPTION 2007 | |
| Γλώσσα Πλήρους Κειμένου – Full Text Language | Αγγλικά – English |
| Παραγγελία – Αγορά – Order – Buy | Ηλεκτρονική Μορφή: pdf (70 €) – Digital Type: pdf (70 €)
pharmakonpress[at]pharmakonpress[.]gr |
| Έντυπη Μορφή (70 € + έξοδα αποστολής) – Printed Type (70 € + shipping)
pharmakonpress[at]pharmakonpress[.]gr |
|