Τόμος 24 (2010) – Τεύχος 1 – Άρθρο 8 – Επιθεώρηση Κλινικής Φαρμακολογίας και Φαρμακοκινητικής-Διεθνής Έκδοση – Volume 24 (2010) – Issue 1 – Article 8 – Epitheorese Klinikes Farmakologias και Farmakokinetikes-International Edition

Title Surfactant in premature infants with chronic lung disease
Authors Christos Tsakalidis, Evangelia Giougi, Anastasia Kalesi and Charalampos Dokos

2nd Neonatal Intensive Care Unit, General Hospital Papageorgiou, Aristotle University, Thessaloniki, Hellas

Citation Tsakalidis, C., Giougi, E., Kalesi, A., Dokos, C.: Surfactant in premature infants with chronic lung disease, Epitheorese Klin. Farmakol. Farmakokinet. 24(1): 49-53 (2010)
Publication Date Accepted for publication (Final Version): April 10, 2010
Full Text Language English
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Keywords Chronic lung disease, respiratory distress syndrome, neonates, surfactant, premature.
Other Terms review article
Summary Chronic lung disease (CLD) of premature neonates is a new term defining a specific group of infants with significant respiratory problems. As a consequence these premature neonates need not only oxygen supply but also mechanical ventilation. The main causes of CLD include prematurity, mechanical trauma and oxygen toxicity while there are other factors involved in the pathophysiological basis of CLD. This review examines not only the pathophysiology and etiology of CLD but also the role of surfactant in premature CLD. Surfactant seems to be an important factor, altered in CLD condition according to experimental and clinical studies.
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