| Title | Endogenous neurogenesis and Alzheimer’s disease: topics in regenerative medicine | |
| Authors | Vassiliki-Sofia Grech1, Maria Grech2, Antonios Togias3 and Ioanna Grech4
1. Bachelor of Medical Biochemistry, King’s College University, Student of Medicine, Medical University of Pecs, Hungary 2. Medical Resident in Pediatrics, Children’s Hospital Aglaia Kyriakou, Athens, Hellas 3. Medical Resident in Pediatrics, General Hospital of Kalamata 4. Technological Education Institution of Athens, Egaleo, Athens, Hellas |
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| Citation | Grech, V.-S., Grech, M., Togias, A., Grech, I.: Endogenous neurogenesis and Alzheimer’s disease: topics in regenerative medicine, Epitheorese Klin. Farmakol. Farmakokinet. 26(2): 109-122 (2012) | |
| Publication Date | Accepted for publication (Final Version): July 1, 2012 | |
| Full Text Language | English | |
| Order – Buy | Ηλεκτρονική Μορφή: pdf (10 €) – Digital Type: pdf (10 €)
pharmakonpress[at]pharmakonpress[.]gr |
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| Keywords | Alzheimer’s Disease, epidemiology, statistics, neuropathology, endogenous neurogenesis, adult brain, future prospects. | |
| Other Terms | Review article | |
| Summary | Alzheimer’s Disease (AD) is the most prevalent form of Dementia, which is a gradual loss of memory, judgment, and ability to function and the sixth leading cause of death in Developed World. This disorder usually appears in people older than age 65, but less common forms of the disease appear earlier in adulthood. Research advances have enabled detailed understanding of the molecular pathogenesis of the hallmarks of the disease, i.e., plaques, composed of amyloid bet, and tangles, composed of hyperphosphorylated tau. Mutations in the amyloid precursor protein, presenilin 1 and presenilin 2 genes cause autosomal dominant familial Alzheimer’s disease (AD). PSEN1 and PSEN2 are essential components of the gamma-secretase complex, which cleaves APP to affect Abeta processing. Recent advances in develop-mental and stem cell biology have made regeneration-based therapies feasible as therapeutic strategies for patients with damaged central nervous systems, including those with spinal cord injuries, Parkinson disease, or stroke. This review provides information meant to increase an understanding of the public-health impact of AD, including incidence and prevalence, mortality, lifetime risks, costs, impact on family caregivers, AD neuropathology, endogenous neurogenesis in adult brain and future prospects. | |
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