| Title | Plasma levels of the neurohypophysial protein 7B2 during the physiological menstrual cycle and the menopause | |
| Authors | Maria S. Venetikou1, Mohammad A. Ghatei2, Jackie M. Burrin3 and Stephen R. Bloom2
Endocrine Unit, Department of Medicine, Hammersmith Hospital, London, UK 1. Department of Medical Essential Lessons, Faculty of Health and Caring Professions, Technological Educational Institute of Athens (TEI), Egaleo, Athens, Greece 2. Department of Endocrinology, St Bartholomew’s and the Royal London School of Medicine and Dentistry, London, UK 3. Department of Investigative Medicine, Imperial College, Hammersmith Hospital, London, UK |
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| Citation | Venetikou, M.S., Ghatei, M.A., Burrin, J.M., Bloom, S.R.: Plasma levels of the neurohypophysial protein 7B2 during the physiological menstrual cycle and the menopause, Epitheorese Klin. Farmakol. Farmakokinet. 22(3): 375-381 (2008) | |
| Publication Date | Accepted for publication (Final Version): 10 July 2008 | |
| Full Text Language | English | |
| Order – Buy | Ηλεκτρονική Μορφή: pdf (10 €) – Digital Type: pdf (10 €)
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| Keywords | 7B2, pituitary protein, normal menstrual cycle, menopause. | |
| Other Terms | Review article | |
| Summary | The neurohypophysial protein 7B2 was isolated from the pituitary and was found to be located in the gonadotrophs. We studied the variations of plasma levels of 7B2-Immunoreactivity (7B2-IR) in healthy volunteers during the various phases of the normal menstrual cycle and compared these values with those of postmenopausal women. Twelve healthy (12) volunteers (mean age 28.6±14 [SD], range 17-39 years) were studied in the follicular phase (5th day), the ovulatory phase (14th -18th day) and luteal phase (25th day) of the cycle. Levels of 7B2, LH, FSH, oestradiol and progesterone were estimated. Twenty five (25) healthy postmenopausal women (mean age 55.6±20 [SD], range 49-62 years) were also studied for 7B2, FSH, LH and oestradiol levels. In 12 healthy volunteers, in the follicular phase of the menstrual cycle, 7B2 was 26.4±1.73 pmol/l (mean±SEM). The 14th day, 26.4±1.83, the 16th day 27.3±1.73, the 17th day 26.9±1.76, the 18th day 26.6±0.75 pmol/l. In the luteal phase 7B2 levels were 28.9±0.63 pmol/l. During the follicular and ovulatory phase, there was a correlation between 7B2 and LH (r = 0.66, p <0.02 and r = 0.67, p <0.02, respectively). During the luteal phase, there was no correlation between 7B2 and LH. In the postmenopausal group (n = 25), LH, FSH and oestradiol fluctuated, but all were within the postmenopausal levels. 7B2-IR was 46±3.0 pmol/l. There was significance difference in plasma 7B2 levels between premenopausal and postmenopausal women (p <0.05). In conclusion, plasma 7B2-IR does not differ significantly during the phases of the menstrual cycle. Changes in 7B2 plasma levels during the menopause either presents age differences or a close physiological relationship with the gonadotrophins due to their over-production. | |
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