| Title | Heroin metabolites detection in saliva and blood | |
| Authors | C. Pourzitaki¹, H. Tachou², N. Raikos², D. Kouvelas¹, H. Tsoukali² and D. Psaroulis²
Laboratories of 1. Pharmacology and 2. Forensic Medicine and Toxicology, School of Medicine, Aristotle University of Thessaloniki |
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| Citation | Pourzitaki, C., Tachou, H., Raikos, N., Kouvelas, D., Tsoukali, H. et al: Heroin metabolites detection in saliva and blood, Epitheorese Klin. Farmakol. Farmakokinet. 20(2): 108-109 (2006) | |
| Publication Date | Accepted for publication: 19-20 May 2006 | |
| Full Text Language | English | |
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| Keywords | Heroin, 6-monacetylomorphine, morphine, saliva. | |
| Other Terms | review article | |
| Summary | Saliva is a valuable biological liquid for forensic toxicology and clinical pharmacokinetics because it combines noninvasive sampling and no requirements for special facilities. The aim of the present research was to investigate the correlation between heroin’s metabolites 6-monacetylomorphine (6-MAM) and morphine in saliva and plasma. Samples were taken from 18 heroin addicts and analyzed by the enzyme-multiplied immunoassay technique (EMIT), followed by gas chromatography with nitrogen-phosphorus detection (GC-NPD). The results indicate that there is no statistically significant difference between plasma and saliva 6-MAM concentration during 2 hours following heroin’s use, while there is statistically significant correlation between them from the 3rd to the 6th hour. The results indicate that saliva could be useful as an analytical tool in toxicology and clinical pharmacology for heroin and other opioids detection, especially for acute sampling and concomitantly with recorded drug concentrations in other biological fluids as plasma or urine. | |
| References | 1. Gorodetzky C.W., Kullberg M.P.: Validity of screening methods for drugs of abuse in biological fluids. II. Heroin in plasma and saliva. Clin. Pharmacol. Ther. 15: 579-587 (1974)
2. Goldberger B.A., Darwin W.D., Grant T.M., Allen A.C., Caplan Y.H., Cone E.J.: Measurement of heroin and its metabolites by isotope-dilution electron-impact mass spectrometry. Clin. Chem. 39: 670-675 (1993) 3. Presley L., Lehrer M., Seiter W., Hahn D., Rowland B., Smith M., Kardos K.W., Fritch D., Salamone S., Niedbala R.S., Cone E.J.: High prevalence of 6-acetylmorphine in morphine – positive oral fluid specimens. Forensic. Sci. Int. 133: 22-25 (2003) 4. Jones J., Tomlinson K., Moore C.: The simultaneous determination of codeine, morphine, hydrocodone, hydro-morphone, 6-acetylmorphine, and oxycodone in hair and oral fluid. J. Anal. Toxicol. 26: 171-175 (2002) 5. Yacoubian G.S. Jr, Wish E.D., Perez D.M.: A comparison of saliva testing to urinalysis in an arrestee population. J. Psychoactive Drugs 33: 289-294 (2001) 6. Wang W.L., Darwin W.D., Cone E.J.: Simultaneous assay of cocaine, heroin and metabolites in hair, plasma, saliva and urine by gas chromatography-mass spectrometry. J. Chromatogr. B. Biomed. Appl. 660: 279-290 (1994) 7. Samyn N., van Haeren C.: On-site testing of saliva and sweat with Drugwipe and determination of concentrations of drugs of abuse in saliva, plasma and urine of suspected users. Int. J. Legal Med. 113: 150-154 (2000) 8. Niedbala R.S., Kardos K., Waga J., Fritch D., Yeager L., Doddamane S., Schoener E.: Laboratory analysis of remotely collected oral fluid specimens for opiates by immunoassay. J. Anal. Toxicol. 25: 310-315 (2001) 9. Skopp G., Potsch L., Klinder K., Richter B., Aderjan R., Mattern R.: Saliva testing after single and chronic administration of dihydrocodeine. Int. J. Legal Med. 114: 133-140 (2001) 10. Jenkins A.J., Oyler J.M., Cone E.J.: Comparison of heroin and cocaine concentrations in saliva with concentrations in blood and plasma. J. Anal. Toxicol. 19: 359-374 (19 |
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Online ISSN 1011-6575
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Articles published in this Journal are Indexed or Abstracted in: • Chemical Abstracts • Elsevier’s Bibliographic Databases: Scopus, EMBASE, EMBiology, Elsevier BIOBASE SCImago Journal and Country Rank Factor
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