Title | 2-Deoxy-2-[18F]fluoro-D-glucose (FDG) as a tracer in Positron Emission Tomography (PET) | |
Authors | Athanassios Zissimopoulos1, Charilaos Koutis2 and Fotoula Babatsikou2
1. Medical School, Demokritus University of Thrace, Alexandroupolis, Greece 2. Department of Hygiene and Epidemiology, Technological Educational Institution of Athens (TEI), Athens, Greece |
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Citation | Zissimopoulos, A., Koutis, C., Babatsikou, F.: 2-Deoxy-2-[18F]fluoro-D-glucose (FDG) as a tracer in Positron Emission Tomography (PET), Epitheorese Klin. Farmakol. Farmakokinet. 22(3): 415-417 (2008) | |
Publication Date | Accepted for publication (Final Version): 10 July 2008 | |
Full Text Language | English | |
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Keywords | 2-Deoxy-2-[18F]fluoro-D-glucose (FDG), Positron Emission Tomography (PET). | |
Other Terms | Review article | |
Summary | The continuing development of new and specific diagnostic and therapeutic tracers, and new instrumentation, is characteristic of nuclear medicine. Positron Emission Tomography (PET) is an imaging modality which has been around since the early sixties and gained clinical acceptance in oncology. This article attempts to present FDG kinetics in PET imaging in oncology. | |
References | 1. Warburg O.: The Metabolism of Tumors. Smith RR, NY, 1931
2. Weber G.: Biochemical strategy of cancer cells and the design of chemotherapy. GHA Clowes Memorial Lecture. Cancer Res. 43: 3466-3492 (1983) 3. Warburg O.: On the origin of cancer cells. Science 123: 309-314 (1956) 4. Weber G.: Enzymology of cancer cells (second part). N. Engl. J. Med. 296: 541-551 (1977) 5. Weber M.J., Nakamura K.D., Salter D.W.: Molecular events leading to enhanced glucose transport in rous sarcoma virus-transformed cells. Fed. Proc. 43: 2246-2250 (1984) 6. Flier J.S., Mueckler M.M., Usher P., et al.: Elevated levels of glucose transport and transporter messenger RNA are induced by ras or src oncogenes. Science 235: 1492-1495 (1987) 7. Hiraki Y., Rosen O.M., Birnbaum M.J.: Growth factors rapidly induce expression of the glucose transporter gene. J. Biol. Chem. 263: 13655-13662 (1988) 8. Younes M., Brown R.W., Stephenson M., et al.: Overexpression of glut-1 and glut-3 in stage I non-small cell lung cancer is associated with poor survival. Cancer 80: 1046-1051 (1997) 9. Brown R.S., Wahl R.: Overexpression of glut-1 glucose transporter in human breast cancer: An immunohistochemical study. Cancer 72: 2979-2985 (1993) 10. Higashi T., Tamaki N., Honda T., et al.: Expression of glucose transporters in human pancreatic tumors compared with increased FDG accumulation in PET study. J. Nucl. Med. 38: 1337-1344 (1997) 11. Knox E.W., Jamdar S.C., Davis P.A.: Hexokinase, differentiation and growth rates of transplanted rat tumors. Cancer Res. 30: 2240-2244 (1970) 12. Weber G., Cantero A.: Glucose-6-phosphatase activity in normal, precancerous and neoplastic tissues. Cancer Res. 15: 105-108 (1995) 13. Di Chiro G.: Positron emission tomography using (18F) fluorodeoxyglucose in brain tumors. A powerful diagnostic and prognostic tool. Invest. Radiol. 22: 360-371 (1987) 14. Gallagher B.M., Anasri A., Atkins M., et al.: Radiopharmaceuticals XXVII. 18F-labeled 2-deoxy-2-fluoro-D-glucose as a radiopharmaceutical for measuring regional myocardia] glucose metabolism in vivo: Tissue distribution and imaging studies in animals. J. Nucl. Med. 18: 990-996 (1997) 15. Monakhov N.K., Neistadt E.L., Shavlovski M.M., et al.: Physiochemical properties and isoenzyme composition of hexo-kinase from normal and malignant human tissues. J. Natl. Cancer Inst. 61: 27-34 (1978) 16. Gallagher B.M., Fowler J.S., Gutterson N.l., MacGregor R.R., Wan C.N., Wolf A.P.: Metabolic trapping as a principle of radiopharmaceutical design: Some factors responsible for the biodistribution of [18F] 2-deoxy-2-fluoro-D-glucose. J. Nucl. Med. 19: 1154-1161 (1978) 17. Som P., Atkins H.L., Bandoypadhyay D., et al.: A fluorinated glucose analog, 2-fluoro-2-deoxy-D-glucose (F-18): Nontoxic tracer for rapid tumor detection. J. Nucl. Med. 21: 670-675 (1980) 18. Zasadny K., Wahl R.L.: Standardized uptake values of normal tissues at PET with 2-[fluorine-18]-fluoro-2-deoxy-D-glucose: variations with body weight and a method for correction. Radiology 189: 847-850 (1993) 19. Di Chiro G., DeLaPaz R.L., Brooks R.A., et al.: Glucose utilization of cerebral gliomas measured by (18F) fluorodeoxy-glucose and positron emission tomography. Neurology 32: 1323-1329 (1982) |
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Online ISSN 1011-6575
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Articles published in this Journal are Indexed or Abstracted in: • Chemical Abstracts • Elsevier’s Bibliographic Databases: Scopus, EMBASE, EMBiology, Elsevier BIOBASE SCImago Journal and Country Rank Factor
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