| Title | Sibutramine reduces food intake and body weight-increasing rate of rats fed a long term high fat diet independently of serum TNF-α levels | |
| Authors | M. Trapali³, Th. Stroubini¹, C. Liapi¹, I. Dontas², D. Perrea², K. Marinou², M. Mavri³ and P. Galanopoulou¹
1. Laboratory of Experimental Pharmacology 2. Laboratory for Experimental Surgery and Surgical Research Christeas Hall, School of Medicine 3. Laboratory of Biochemistry, Department of Chemistry, University of Athens, Athens, Greece |
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| Citation | Trapali, M., Stroubini, Th., Liapi, C., Dontas, I., Perrea, D. et al: Sibutramine reduces food intake and body weight-increasing rate of rats fed a long term high fat diet independently of serum TNF-a levels, Epitheorese Klin. Farmakol. Farmakokinet. 20(2): 114-116 (2006) | |
| Publication Date | Accepted for publication: 19-20 May 2006 | |
| Full Text Language | English | |
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| Keywords | TNF-a, Sibutramine, high fat diet, obesity. | |
| Other Terms | review article | |
| Summary | TNF-α is a cytokine with a key role in the control of body mass in normal weight-controlled situations while abnormalities in either its production during cachexia or its action during obesity are responsible for the lack of control of body weight. Sibutramine is a noradrenaline and serotonin reuptake inhibitor, which induces weight loss by enhancing satiety and increasing thermogenesis. The aim of the study was to investigate if eventual changes on High Fat Diet intake (HFD) and Body Weight caused by (S) could be correlated to alterations on serum TNF-α levels of rats. 42 male Wistar rats separated in 2 Groups (n=21/ Group) were fed with HFD or Standard Diet (SD) for 13 weeks. The last 3 weeks each Group divided into 3 sub- groups (n=7/subgroup) received: Sibutramine-HCL (S) 5mg/kg, (S) 10 mg/kg or vehicle. Food intake was measured daily the last week of the experiment, while Body Weight weekly. Caloric intake and Body Weight-Increasing Rate (BW-IR) were calculated and serum TNF-α levels were estimated by Elisa. HFD increased caloric intake and BW-IR of rats compared to SD. A significant decrease on food intake and BW-IR of rats fed the HFD after (S) treatment at 10 mg/kg compared to vehicle treatment was observed. Serum TNF-α levels were increased in all rats fed the HFD compared to those fed the SD. Results suggest that HFD intake increases TNF-α levels in serum, or this is the result of BW-IR of rats after fat intake. Sibutramine, by its actions on appetite and thermogenesis, tries to reverse this situation without involvement of TNF-α on its effects. | |
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Online ISSN 1011-6575
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Articles published in this Journal are Indexed or Abstracted in: • Chemical Abstracts • Elsevier’s Bibliographic Databases: Scopus, EMBASE, EMBiology, Elsevier BIOBASE SCImago Journal and Country Rank Factor
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