| Title | Relationship between a polymorphism of the eNOS gene and myocardial infarction in a subgroup of Greek MI patients | ||
| Authors | Chaido Dafni1, Dennis V. Cokkinos4, Olfert Landt2, Dimitris Panidis1, Martin Reczko3 and Nikolaos Drakoulis1
1. Department of Pharmaceutical Technology, School of Pharmacy, University of Athens, Panepistimiopolis Zografou, GR-15771, Athens, Hellas 2. TIB MOLBIOL, 22-23 Eresburstrasse, D-12103 Berlin, Germany 3. Institute of Molecular Oncology, Biomedical Sciences Research Center Alexander Fleming, P.O. Box 74145, GR-16602, Vari, Hellas 4. 1st Cardiology Department, Onassis Cardiac Surgery Center, 356 Sygrou Avenue, GR-17674 Kallithea, Athens, Hellas |
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| Citation | Dafni, C., Cokkinos, D.V., Landt, O., Panidis, D. et al.: Relationship between a polymorphism of the eNOS gene and myocardial infarction in a subgroup of Greek MI patients, Epitheorese Klin. Farmakol. Farmakokinet. 24(2): 130-132 (2010) | ||
| Publication Date | 2010 | ||
| Full Text Language | English | ||
| Order – Buy | Ηλεκτρονική Μορφή: pdf (10 €) – Digital Type: pdf (10 €)
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| Keywords | eNOS gene, myocardial infarction, nitric oxide synthase, nitric oxide. | ||
| Other Terms | Review article | ||
| Summary | Nitric oxide (NO), produced by endothelial nitric oxide synthase (eNOS), plays a key role in the regulation of vascular tone. The E298D polymorphic variant of eNOS has been associated with myocardial infarction (MI), but data relating to this variant are divergent in Greece. Accordingly, we examined a possible association between the E298D polymorphism of the eNOS gene and MI in a subgroup of the Greek population. The study population consisted of 204 patients with a history of MI and 218 control subjects. All subjects were of Greek origin. According to the univariate findings, the risk for MI in E298D TT was 2.06 (95%CI: 1.06-4.00, p=0.032) versus GG+GT and 2.34 (95%CI: 1.17-4.68, p=0.016) versus GG. The risk for the T allele was estimated at 1.42 (95%CI, 1.06-1.89, p=0.022) as compared to G allele. The positive association of TT versus GG+GT with MI risk remained even after adjusting for the main study covariates. Moreover, strong evidence was found for an increased risk for MI among carriers of the TT genotype who were smokers, hypertensive and had a family history of CAD. This study indicates that E298D polymorphism of the eNOS gene seems to be associated with MI occurrence in the Greek population. It is possible that TT genotype is closely linked to the etiology of MI even after adjusting for known MI risk factors. | ||
| References | 1. Moncada S., Higgs A.: The L-arginine-nitric oxide pathway. N. Engl. J. Med. 329: 2002-2012 (1993)
2. Marsden P.A., Heng H.H., Scherer S.W., Stewart R.J., Hall A.V., Shi X.M., Tsui L.C., Schappert K.T.: Structure and chromosomal localization of the human constitutive endothelial nitric oxide synthase gene. J. Biol. Chem. 268: 17478-17488 (1993) 3. Hingorani A.D., Jia H., Stevens P.A., Hopper R., Dickerson J.E., Brown M.J.: Renin-angiotensin system gene polymorphisms influence blood pressure and the response to angiotensin converting enzyme inhibition. J. Hypertens. 13(12 Pt 2): 1602-1609 (1995) 4. Hibi K., Ishigami T., Tamura K., Mizushima S., Nyui N., Fujita T., Ochiai H., Kosuge M., Watanabe Y., Yoshii Y., et al.: Endothelial nitric oxide synthase gene polymorphism and acute myocardial infarction. Hypertension 32: 521-526 (1998) 5. Hingorani A.D., Liang C.F., Fatibene J., Lyon A., Monteith S., Parsons A., Haydock S., Hopper R.V., Stephens N.G., O’Shaughnessy K.M., et al.: A common variant of the endothelial nitric oxide synthase (Glu298->Asp) is a major risk factor for coronary artery disease in the UK. Circulation 100: 1515-1520 (1999) 6. Gardemann A., Lohre J., Cayci S., Katz N., Tillmanns H., Haberbosch W.: The T allele of the missense Glu(298)Asp endothelial nitric oxide synthase gene polymorphism is associated with coronary heart disease in younger individuals with high atherosclerotic risk profile. Atherosclerosis 160: 167-175 (2002) 7. Morray B., Goldenberg I., Moss A.J., Zareba W., Ryan D., McNitt S., Eberly S.W., Glazko G., Mathew J.: Polymorphisms in the paraoxonase and endothelial nitric oxide synthase genes and the risk of early-onset myocardial infarction. Am. J. Cardiol. 99: 1100-1105 (2007) 8. Jo I., Moon J., Yoon S., Kim H.T., Kim E., Park H.Y., Shin C., Min J., Jin Y.M., Cha S.H., et al.: Interaction between -786TC polymorphism in the endothelial nitric oxide synthase gene and smoking for myocardial infarction in Korean population. Clin. Chim. Acta 365(1-2): 86-92 (2006) 9. Schmoelzer I., Renner W., Paulweber B., Malaimare L., Iglseder B., Schmid P., Schallmoser K., Wascher T.C.: Lack of association of the Glu298Asp polymorphism of endothelial nitric oxide synthase with manifest coronary artery disease, carotid atherosclerosis and forearm vascular reactivity in two Austrian populations. Eur. J. Clin. Invest. 33: 191-198 (2003) 10. Poirier O., Mao C., Mallet C., Nicaud V., Herrmann S.M., Evans A., Ruidavets J.B., Arveiler D., Luc G., Tiret L., et al: Polymorphisms of the endothelial nitric oxide synthase gene – no consistent association with myocardial infarction in the ECTIM study. Eur. J. Clin. Invest. 29: 284-290 (1999) 11. Agema W.R., de Maat M.P., Zwinderman A.H., Kastelein J.J., Rabelink T.J., van Boven A.J., Feskens E.J., Boer J.M., van der Wall E.E., Jukema J.W.: An integrated evaluation of endothelial constitutive nitric oxide synthase polymorphisms and coronary artery disease in men. Clin. Sci. (London) 107: 255-261 (2004) 12. Antoniades C., Tousoulis D., Vasiliadou C., Pitsavos C., Chrysochoou C., Panagiotakos D., Tentolouris C., Marinou K., Koumallos N., Stefanadis C.: Genetic polymorphism on endothelial nitric oxide synthase affects endothelial activation and inflammatory response during the acute phase of myocardial infarction. J. Am. Coll. Cardiol. 46: 1101-1109 (2005) 13. Antoniades C., Tousoulis D., Vasiliadou C., Pitsavos C., Toutouza M., Tentolouris C., Marinou K., Stefanadis C.: Genetic polymorphisms G894T on the eNOS gene is associated with endothelial function and vWF levels in premature myocardial infarction survivors. Int. J. Cardiol. 107: 95-100 (2006) 14. Andrikopoulos G.K., Grammatopoulos K., Tzeis S.E., Zervou S.I., Richter D.J., Zairis M.N., Gialafos E.J., Sakellariou D.C., Foussas S.G., Manolis A.S., et al.: Association of the 894G>T polymorphism in the endothelial nitric oxide synthase gene with risk of acute myocardial infarction. BMC Med. Genet. 9: 43 (2008) 15. Alpert J.S., Thygesen K., Antman E., Bassand J.P.: Myocardial infarction redefined–a consensus document of The Joint European Society of Cardiology/American College of Cardiology Committee for the redefinition of myocardial infarction. J. Am. Coll. Cardiol. 36: 959-969 (2000) |
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Online ISSN 1011-6575
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