Τόμος 24 (2010) – Τεύχος 2 – Άρθρο 54 – Επιθεώρηση Κλινικής Φαρμακολογίας και Φαρμακοκινητικής-Διεθνής Έκδοση – Volume 24 (2010) – Issue 2 – Article 54 – Epitheorese Klinikes Farmakologias και Farmakokinetikes-International Edition

Title Association between inflammatory markers and disease severity assessment in psoriatic patients treated with etanercept
Authors A. Kanelleas1, C. Liapi2, A. Grafakos1, K. Theodoropoulos1, D. Pantelis1, T. Economopoulos3 and N. G. Stavrianeas1

1. Second Department of Dermatology and Venereology, National and Kapodistrian University of Athens, Medical School, Attikon University General Hospital, Athens, Greece

2. Department of Pharmacology, National and Kapodistrian University of Athens, Medical School

3. Second Department of Internal Medicine, National and Kapodistrian University of Athens, Medical School, Attikon University General Hospital, Athens, Greece

Citation Kanelleas, A., Liapi, C., Grafakos, K., Theodoropoulos K., Pantelis, D. et al.: Association between inflammatory markers and disease severity assessment in psoriatic patients treated with etanercept, Epitheorese Klin. Farmakol. Farmakokinet. 24(2): 151-152 (2010)
Publication Date 2010
Full Text Language English
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Keywords Psoriasis, inflammation, Etanercept, treatment.
Other Terms Review article
Summary Psoriasis is a common, inflammatory, chronic skin disease. Its precise aetiology is unknown. Immunological responses via T-cell activation as well as a cascade of inflammatory reactions play a central role in its pathogenesis. We measured an array of inflammatory markers in psoriatic patients at baseline and after twelve weeks of Etanercept treatment. Statistical analysis suggested that there might be an association between disease severity assessments, as this is clinically described by PASI, and inflammatory markers (fibrinogen at baseline and hs-CRP at the end of treatment).
References 1. Griffiths CEM, Barker JNWN. Pathogenesis and clinical features of psoriasis. Lancet 2007; 370: 263-71.

2. Lowes MA, Bowcock AM, Krueger JG. Pathogenesis and therapy of psoriasis. Nature 2007; 445: 866-873.

3. Nickoloff BJ.  Cracking the cytokine code in psoriasis. Nat Med 2007; 13: 242-4.

4. Pathirana D, Ormerod AD, Saiag P et al. European S3-Guidelines on the systemic treatment of psoriasis vulgaris. J Eur Acad Dermatol Venereol 2009; 23 (suppl 2): 34-8

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ΕΤΗΣΙΑ ΣΥΝΔΡΟΜΗ 2010 – ANNUAL SUBSCRIPTION 2010
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