| Title | Mechanisms of interactions between ethyl alcohol and pharmaceutical substances | ||
| Authors | Petros Karamanakos1, Periklis Pappas1, Vassiliki Boumba2, Theodore Vougiouklakis2 and Marios Marselos1
1. Department of Pharmacology and 2. Department of Forensic Medicine and Toxicology, Medical School, University of Ioannina, Ioannina, Greece |
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| Citation | Karamanakos, P. Pappas, P., Boumba, V., Vougiouklakis, T., Marselos, M.: Mechanisms of interactions between ethyl alcohol and pharmaceutical substances, Epitheorese Klin. Farmakol. Farmakokinet. 24(2): 153-155 (2010) | ||
| Publication Date | 2010 | ||
| Full Text Language | English | ||
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| Keywords | Alcohol intolerance, Aldehyde dehydrogenase, Serotonin, Disulfiram-like reaction, Serotonin syndrome. | ||
| Other Terms | Review article | ||
| Summary | The use of ethyl alcohol together with prescription drugs has been implicated in several pharmacodynamic and pharmacokinetic interactions with clinical consequences. Synergy is expected with sedative substances either as prescribed drugs, like benzodiazepines and tricyclic antidepressants, or as drugs of abuse, such as cannabis and opiates. On the contrary, pharmacokinetic interactions are unpredictable and difficult to recognize, as it is exemplified in the case of disulfiram. The so called “disulfiram reaction” has been attributed to the accumulation of acetaldehyde in the blood due to inhibition of the hepatic aldehyde dehydrogenase (ALDH). In addition to disulfiram, clinically similar toxic reactions have been reported for at least ten more pharmaceutical substances, which have been assumed to inhibit also ALDH. However, a more detailed investigation reveals that other mechanisms may be equally important. This article reports some examples of pharmaceutical substances with known “disulfiram-like reactions”, which were scrutinized in order to clarify the underlying mechanism. | ||
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| Relative Papers | |||
Online ISSN 1011-6575
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Articles published in this Journal are Indexed or Abstracted in: • Chemical Abstracts • Elsevier’s Bibliographic Databases: Scopus, EMBASE, EMBiology, Elsevier BIOBASE SCImago Journal and Country Rank Factor
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