| Title | Regulator of G protein signaling 4: a novel regulator of μ– and δ-opioid receptor signaling | ||
| Authors | Leonidas J. Leontiadis, Maria P. Papakonstantinou and Zafiroula Georgoussi
Laboratory of Cellular Signaling and Molecular Pharmacology, Institute of Biology, National Centre for Scientific Research Demokritos, Athens, Greece |
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| Citation | Leontiadis, L.J., Papakonstantinou, M.P., Georgousi, Z.: Regulator of G protein signaling 4: a novel regulator of μ– and δ-Opioid receptor signaling, Epitheorese Klin. Farmakol. Farmakokinet. 24(2): 168-170 (2010) | ||
| Publication Date | 2010 | ||
| Full Text Language | English | ||
| Order – Buy | Ηλεκτρονική Μορφή: pdf (10 €) – Digital Type: pdf (10 €)
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| Keywords | Regulator of G protein signaling, G protein, internalization, extracellular signal-regulated kinases, protein-protein interactions. | ||
| Other Terms | Review article | ||
| Summary | In vitro studies have shown that the Regulator of G protein Signaling 4 (RGS4) interacts with the C-termini of μ– and δ-opioid receptors (μ-OR, δ-OR) (1). Herein we demonstrate that RGS4 associates with these receptors in living cells and forms selective complexes with Gi/o proteins in a receptor dependent manner. This interaction occurs within the predicted fourth intracellular loop of μ, δ-ORs as part of a signaling complex consisting of the opioid receptor, activated Gα and RGS4. Expression of RGS4 in HEK293 cells attenuated agonist-mediated ERK1,2 phosphorylation for both receptors and accelerated agonist-induced internalization of the δ-OR. Our findings demonstrate that RGS4 plays a key role in G protein coupling selectivity and signaling of the μ– and δ–ΟRs. | ||
| References | 1. Georgoussi Z., Leontiadis L., Mazarakou G., Merkouris M., Hyde K., Hamm H.: Cell. Signal. 18: 771-782 (2006)
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| Relative Papers | |||
Online ISSN 1011-6575
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Articles published in this Journal are Indexed or Abstracted in: • Chemical Abstracts • Elsevier’s Bibliographic Databases: Scopus, EMBASE, EMBiology, Elsevier BIOBASE SCImago Journal and Country Rank Factor
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