Τόμος 24 (2010) – Τεύχος 2 – Άρθρο 71 – Επιθεώρηση Κλινικής Φαρμακολογίας και Φαρμακοκινητικής-Διεθνής Έκδοση – Volume 24 (2010) – Issue 2 – Article 71 – Epitheorese Klinikes Farmakologias και Farmakokinetikes-International Edition

Title Development of a new series of aryl ureido derivatives as anticancer agents against breast cancer cells
Author Ioannis S. Pappas

Laboratory of Pharmacology and Toxicology, Faculty of Veterinary Medicine, University of Thessaly, Karditsa, Greece, and Laboratory of Drug Development, Institute of Technology and Management of Agricultural Ecosystems (Ι.ΤΕ.M.Α.), Centre for Research and Technology of Thessaly (CERETETH), Karditsa, Greece

Citation Pappas, I.S.: Development of a new series of aryl ureido derivatives as anticancer agents against breast cancer cells, Epitheorese Klin. Farmakol. Farmakokinet. 24(2): 190-192 (2010)
Publication Date 2010
Full Text Language English
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Keywords Breast cancer, aryl ureido derivatives, cell growth inhibitors, cancer therapy.
Other Terms Review article
Summary Breast cancer is the second cause of cancer mortality worldwide in humans and half of all tumours in dogs and there is an unmet need for novel anticancer agents. I have developed a new series of aryl ureido derivatives as anticancer agents. These compounds have a strong antiproliferative effect against canine breast cancer CMT-U27 cells at concentrations (1-10 μΜ) comparable to drugs that have already been used in chemotherapy such as gefitinib, soferanib and lapatinib. These results suggest that aryl ureido derivatives were potent inhibitors of proliferation of breast cancer cells. 
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