Title | Development of a new series of aryl ureido derivatives as anticancer agents against breast cancer cells | ||
Author | Ioannis S. Pappas
Laboratory of Pharmacology and Toxicology, Faculty of Veterinary Medicine, University of Thessaly, Karditsa, Greece, and Laboratory of Drug Development, Institute of Technology and Management of Agricultural Ecosystems (Ι.ΤΕ.M.Α.), Centre for Research and Technology of Thessaly (CERETETH), Karditsa, Greece |
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Citation | Pappas, I.S.: Development of a new series of aryl ureido derivatives as anticancer agents against breast cancer cells, Epitheorese Klin. Farmakol. Farmakokinet. 24(2): 190-192 (2010) | ||
Publication Date | 2010 | ||
Full Text Language | English | ||
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Keywords | Breast cancer, aryl ureido derivatives, cell growth inhibitors, cancer therapy. | ||
Other Terms | Review article | ||
Summary | Breast cancer is the second cause of cancer mortality worldwide in humans and half of all tumours in dogs and there is an unmet need for novel anticancer agents. I have developed a new series of aryl ureido derivatives as anticancer agents. These compounds have a strong antiproliferative effect against canine breast cancer CMT-U27 cells at concentrations (1-10 μΜ) comparable to drugs that have already been used in chemotherapy such as gefitinib, soferanib and lapatinib. These results suggest that aryl ureido derivatives were potent inhibitors of proliferation of breast cancer cells. | ||
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Online ISSN 1011-6575
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Articles published in this Journal are Indexed or Abstracted in: • Chemical Abstracts • Elsevier’s Bibliographic Databases: Scopus, EMBASE, EMBiology, Elsevier BIOBASE SCImago Journal and Country Rank Factor
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