| Title | Interleukin-13 enhances the expression of interleukin-6 and tissue inhibitor of matrix metalloproteinases-1 by nasal polyp fibroblasts | |
| Authors | Sotiris D. Athanassiou¹, Thothoros Stathas², Panagiotis Goumas², Stefanos Naxakis², Eleftheria Giannopoulou³ and Alexis J. Aletras¹
1. Laboratory of Biochemistry, Department of Chemistry and Departments of 2. 0tolaryngology and 3. Pharmacology, Medical School, University of Patras, Patras 26500, Greece |
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| Citation | Athanassiou, S.D., Stathas, T., Goumas, P., Naxakis, S., Giannopoulou, E. et al: Interleukin-13 enhances the expression of interleukin-6 and tissue inhibitor of matrix metalloproteinases-1 by nasal polyp fibroblasts, Epitheorese Klin. Farmakol. Farmakokinet. 20(2): 133-134 (2006) | |
| Publication Date | Accepted for publication: 19-20 May 2006 | |
| Full Text Language | English | |
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| Keywords | Interleukin-13, nasal polyposis, fibroblasts, interleukin-6, tissue inhibitor of matrix metalloproteinases-1. | |
| Other Terms | review article | |
| Summary | Nasal polyposis is a chronic inflammatory disease of the nasal mucosa, characterized by inflammatory cell infiltration, modifications of epithelial differentiation, and tissue remodeling. Interleukin-13 (IL-13) which is generated by Th2 cells is involved in the pathogenesis of various fibrotic diseases. It induces eotaxin expression promoting the eosinophilic inflammation in nasal mucosa. The purpose of this study was to investigate the effect of IL-13 on the production of interleukin-6 (IL-6) and tissue inhibitor of matrix metalloproteinases-1 (TIMP-1) by nasal polyp fibroblasts. Fibroblasts, isolated from nasal polyps, expressed IL-13 receptors. IL-13 caused a dose and time- dependent increase of IL-6 and TIMP-1 that was not mediated by transforming growth factor-/31 (TGF-/31). RT-PCR showed that IL-13 up-regulates the IL-6 and TIMP-1 expression in a dose and time-dependent manner, while it did not affect the expression of TGF-/31 and its receptors. Since elevated levels of IL-6 and TIMP-1 have been connected with the pathogenesis of several fibrotic lesions, it is proposed that IL-13, might also contribute to nasal polyps pathogenesis by inducing an increase of the extracellular matrix deposition. | |
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Online ISSN 1011-6575
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Articles published in this Journal are Indexed or Abstracted in: • Chemical Abstracts • Elsevier’s Bibliographic Databases: Scopus, EMBASE, EMBiology, Elsevier BIOBASE SCImago Journal and Country Rank Factor
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