| Title | Assessment of vancomycin induced nephrotoxicity by determination of urinary alpha and pi glutathione S-transferase | |
| Authors | E. Haliassos¹,², S. Markantonis-Kyroudis¹, G. Papatheodorou² and N. Drakoulis¹
1. University of Athens, School of Pharmacy, Greece 2. 401 General Military Hospital of Athens, Greece |
|
| Citation | Haliassos, E., Markantonis-Kyroudis, S., Papatheodorou, G., Drakoulis, N.: Assessment of vancomycin induced nephrotoxicity by determination of urinary alpha and pi glutathione S-transferase, Epitheorese Klin. Farmakol. Farmakokinet. 20(2): 168-170 (2006) | |
| Publication Date | Accepted for publication: 19-20 May 2006 | |
| Full Text Language | English | |
| Order – Buy | Ηλεκτρονική Μορφή: pdf (10 €) – Digital Type: pdf (10 €)
pharmakonpress[at]pharmakonpress[.]gr |
|
| Keywords | Vancomycin, nephrotoxicity, glutathione S-transferase, renal tubular damage. | |
| Other Terms | review article | |
| Summary | The aim of the study was (a) to assess the effect of vancomycin on the structural integrity of renal tubules by determination of alpha and pi glutathione S-transferase (αGST and πGST) in urine and (b) to evaluate the predictive value of αGST and πGST for vancomycin induced nephrotoxicity. Ten hospitalized patients, treated with intravenously administered vancomycin, without other nephrotoxic agents present, were included in the study. Serum creatinine, αGST and πGST urinary levels and serum vancomycin concentrations were quantitatively determined. The effect of vancomycin on renal tubular integrity was evaluated by observing the change in urinary excretion rates with respect to baseline values on the first day of treatment. Significant changes in αGST and πGST urinary excretion rates from baseline were noted throughout vancomycin treatment. The observed increase in the urinary excretion rate of αGST and πGST support the idea that structural damage occurred in tubular cells during treatment. The statistical significance of the results allows us to conclude that intravenously administered vancomycin induces renal tubular damage while its concentrations lie within the therapeutic range and serum creatinine is normal. Vancomycin induced nephrotoxicity could not be evaluated using GSTs because no study patients presented renal insufficiency (change in serum creatinine >0.5 mg/dl). | |
| References | 1. Nakamura T., Takano M., Yasuhara M., Inui K.: In vivo clearance study of vancomycin in rats. J. Pharm. Pharmacol. 48: 1197-1200 (1996)
2. Cunha B.A.: Vancomycin. Med. Clin. N. Am. 79: 817-831 (1995) 3. Wilson A.P.R.: Comparative safety of teicoplanin and vancomycin. Int. J. Antim. Agents 10: 143-52 (1998) 4. Rose B.: Vancomycin nephrotoxicity. Up To Date 8: 2 (2000) 5. Perrone D.R., Madias E.N., Andrew S.L.: Serum Creatinine as an Index of Renal Function: New Insights into Old Concepts. Clin. Chem. 38: 1933-1953 (1992) 6. Sundberg A., Appelkvist E., Dallner G., Nilsson R.: Glutathione transferases in the urine: sensitive methods for detection of kidney damage induced by nephrotoxic agents in humans. Environ. Health Perspect. 102 (Suppl 3): 293-296 (1994) 7. Sundberg A., Appelkvist E., Backman L., Dallner G.: Quantitation of glutathione transferase-pi in the urine by radioimmunoassay. Nephron 66: 162-169 (1994) 8. Sundberg A., Nilsson R., Appelkvist E., Dallner G.: ELISA procedures for the quantitation of glutathione transferases in the urine. Kidney Int. 48: 570-575 (1995) 9. Bomhard E., Maruhn D., Vogel O., Mager H.: Determination of urinary glutathione S-transferase and lactate dehydrogenase for differentiation between proximal and distal nephron damage. Arch. Toxicol. 64: 269-278 (1990) 10. Westhuyzen J., Zoltan H., Reece G.: Measurement of tubular enzymuria facilitates early detection of acute renal impairment in the intensive care unit. Nephrol. Dial. Transplant. 18: 543-551 (2003) 11. Mueller P., Lash L., Price R., Stolte H., Gelpi E., Maack T., Berndt W.: Urinary biomarkers to detect significant effects of environmental and occupational exposure to nephrotoxins. Categories of tests for detecting effects of nephrotoxins. Renal Fail. 19: 505-521 (1997) |
|
| Relative Papers |
Online ISSN 1011-6575
Άρθρα Δημοσιευμένα σε αυτό το Περιοδικό Καταχωρούνται στα:
- Chemical Abstracts
- Elsevier’s Bibliographic Databases: Scopus, EMBASE, EMBiology, Elsevier BIOBASE SCImago Journal and Country Rank Factor
Articles published in this Journal are Indexed or Abstracted in: • Chemical Abstracts • Elsevier’s Bibliographic Databases: Scopus, EMBASE, EMBiology, Elsevier BIOBASE SCImago Journal and Country Rank Factor
Συντακτικη Επιτροπή-Editorial Board
| ΕΤΗΣΙΑ ΣΥΝΔΡΟΜΗ 2006 – ANNUAL SUBSCRIPTION 2006 | |
| Γλώσσα Πλήρους Κειμένου – Full Text Language | Αγγλικά – English |
| Παραγγελία – Αγορά – Order – Buy | Ηλεκτρονική Μορφή: pdf (70 €) – Digital Type: pdf (70 €)
pharmakonpress[at]pharmakonpress[.]gr |
| Έντυπη Μορφή (70 € + έξοδα αποστολής) – Printed Type (70 € + shipping)
pharmakonpress[at]pharmakonpress[.]gr |
|