| Title | Corticotropin Releasing Factor (CRF) and liver apoptosis | ||
| Authors | E. Chatzaki1,3, C. Paschos1, M. Lambropoulou2, S. Anagnostoulis1, Ch. Charsou3, E. Chouridou1, E. Michailidou1, F. Papachristou⁴, Th.C. Constantinidis⁵ and C. Simopoulos⁴
1. M.Sc. in HPB Surgery, 2. Laboratory of Histology, 3. Laboratory of Pharmacology, 4. Laboratory of Experimental Surgery, 5. Laboratory of Hygienic and Environmental Protection, School of Medicine, DUTH, Alexandroupolis |
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| Citation | Chatzaki, E., Paschos, C., Lampropoulou, M., Anagnostoulis, S., Charsou, C. et al.: Corticotropin Releasing Factor (CRF) and liver apoptosis, Epitheorese Klin. Farmakol. Farmakokinet. 22(2): 122-123 (2008) | ||
| Publication Date | 2008 | ||
| Full Text Language | English | ||
| Order – Buy | Ηλεκτρονική Μορφή: pdf (10 €) – Digital Type: pdf (10 €)
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| Keywords | Corticotropin Releasing Factor, antagonist, liver, apoptosis, rat. | ||
| Other Terms | Review article | ||
| Summary | The Corticotropin Releasing Factor (CRF) system is expressed in the human and rat liver. Aim of the present study was to unfold a possible regulating role of the CRF system in hepatocellular apoptosis and to investigate the molecular mechanism involved. Liver apoptosis was induced in rats by surgery for hepatic duct ligation causing obstructive jaundice, as shown by elevated expression levels of the early apoptotic marker M30 demonstrated by immunohistochemistry and ELISA in serum levels. Administration of the non-selective CRF receptor antagonist astressin inhibited M30 elevation, in contrast to the specific type 2 CRF receptor antagonist astressin 2B that did not show this action, indicating a CRF1 mediated effect. These results show a role of the CRF receptors in the apoptosis regulating process. The exact molecular mechanism involved needs further investigation. | ||
| References | 1. Ghavami S., Hashemi M., Kadkhoda K.: Apoptosis in liver diseases – detection and therapeutic applications. Med. Sci. Monit. 11: RA337-345 (2005)
2. Chatzaki E., Lambropoulou M., Constantinidis T.C., Papadopoulos N., Tache Y., Minopoulos G., Grigoriadis D.: Corticotropin-Releasing Factor (CRF) Receptor type 2 in the Human Stomach: protective biological role by inhibition of apoptosis. J. Cell. Physiol. 209: 905-11 (2006) 3. Charalampopoulos I., Androulidaki A., Chatzaki E., Minas V., Tsatsanis C., Notas G., Xidakis C., Kollios G., Kouroumalis E., Margioris A.N., Gravanis A.: Rat Kupffer cells express neuropeptide Urocortin (UCN) and its receptors: autocrine effects on inflammatory cytokines. Neuroendocrinology 84: 49-57 (2006) 4. Christodoulou Ε., Kyriaki S., Lambropoulou M., Tsaroucha A., Chatzaki E.: Urocortin (Ucn) and Corticotropin-Releasing Factor (CRF) Receptor expression in the human liver. 57th Meeting of Hellenic Society of Biochemistry and Molecular Biology, Athens, 2005 5. Liu Y., Binz J., Numerick M.J., et al.: Hepatoprotection by the farnesoid X receptor agonist GW4064 in rat models of intra- and extrahepatic cholestasis. J. Clin. Invest. 112: 356-361 (2003) 6. Kramer G., Erdal H., Mertens H.J., Nap M., Mauermann J., Steiner G., Marberger M., Bivén K., Shoshan M.C., Linder S.: Differentiation between cell death modes using measurements of different soluble forms of extracellular cytokeratin 18. Cancer Res. 64: 1751-6 (2004) |
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| Relative Papers | |||
Online ISSN 1011-6575
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Articles published in this Journal are Indexed or Abstracted in: • Chemical Abstracts • Elsevier’s Bibliographic Databases: Scopus, EMBASE, EMBiology, Elsevier BIOBASE SCImago Journal and Country Rank Factor
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