| Title | Eph receptors and ephrin ligands: back to the origin in the therapy of cancer | ||
| Authors | C. Hadjicosta and M. Mironidou-Tzouveleki
A’ Laboratory of Pharmacology, Medical School, Aristotle University of Thessaloniki, Greece |
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| Citation | Hadjicosta, C., Mironidou-Tzouveleki, M.: Eph receptors and ephrin ligands: back to the origin in the therapy of cancer, Epitheorese Klin. Farmakol. Farmakokinet. 22(2): 159-162 (2008) | ||
| Publication Date | 23-25 May 2008 | ||
| Full Text Language | English | ||
| Order – Buy | Ηλεκτρονική Μορφή: pdf (10 €) – Digital Type: pdf (10 €)
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| Keywords | Eph receptors, ephrin genes, ephrin ligants, cancer. | ||
| Other Terms | Review article | ||
| Summary | In the quest for the magic treatment of cancer, researchers implicate that our efforts must focus on the primary stages of tumor growth. In the complex molecular signaling pathways that are involved in the process of tumorigenesis and tumor progression, vascular functions are essential part. Eph receptors, the largest family of receptor tyrosine kinases (classified into A and B family according to corresponding ligands) and ephrin ligand seem to be the key players in arteriovenous differentiation during embryonic vascular development. Even though they were first identified as neuronal pathfinding molecules, the Eph/ephrin system appears to control tumor and vascular functions during tumor growth. They seem to be abnormally expressed in various human tumors (ovarian, lung, breast, melanoma, esophageal, colon, prostate, kidney, glioblastoma, neuroblastoma) and can be considered as ideal prognostic markers of chemotherapy/chemoprevention. Therefore Eph/ephrin system is a future molecular target for drugs. Furthermore through experimental work it seems that inhibition of Eph/ephrin system can be achieved with antibodies. New horizons are opened in this part of therapeutics of cancer, back to the early steps of the tumour development. | ||
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| Relative Papers | |||
Online ISSN 1011-6575
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Articles published in this Journal are Indexed or Abstracted in: • Chemical Abstracts • Elsevier’s Bibliographic Databases: Scopus, EMBASE, EMBiology, Elsevier BIOBASE SCImago Journal and Country Rank Factor
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