| Title | Τhe antagonizing effects of N-acetyl-cysteine on prolactin induced proliferation of human breast cancer cells | ||
| Authors | F.M. Malamas1, C.G. Thomas1, T. Stefos2, A. Tsatsoulis3 and A.M. Evangelou1
1. Laboratory of Physiology, Faculty of Medicine, University of Ioannina, Ioannina, Greece 2. Department of Obstetrics and Gynecology, University Hospital of Ioannina, Medical School of Ioannina, Ioannina, Greece 3. Department of Endocrinology, University Hospital of Ioannina, Medical School of Ioannina, Ioannina, Greece |
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| Citation | Malamas, F.M., Thomas, C.G., Stefos, T., Tsatsoulis, A., Evangelou, A.M.: Τhe antagonizing effects of N-acetyl-cysteine on prolactin induced proliferation of human breast cancer cells, Epitheorese Klin. Farmakol. Farmakokinet. 22(2): 232-234 (2008) | ||
| Publication Date | 23-25 May 2008 | ||
| Full Text Language | English | ||
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| Keywords | Prolactin, N-acetyl-cysteine (NAC), breast cancer, thiol antioxidants, sulphydryl compounds. | ||
| Other Terms | Review article | ||
| Summary | Breast cancer is a hormone dependent disease and the role of prolactin in its pathogenesis and progression has been the subject of considerable debate. Thiol antioxidants including N-Acetyl-L-cysteine (NAC) are among the many substances that have been used in experimental and epidemiological studies for cancer prevention. In this study we examined the effects of prolactin (PRL) and NAC on the growth of MCF-7 human breast cancer cells and the influence of NAC on PRL-induced cell proliferation when both substances were added simultaneously to the culture medium. According to our results, NAC alone at concentrations above 4mM caused a gradual decrease in cell proliferation which was statistically significant at concentrations above 6 mM. Prolactin significantly increased cell proliferation and when PRL and NAC were added simultaneously to the culture medium an inhibitory effect on PRL-induced MCF-7 proliferation was observed at concentrations of 5 and 6 mM NAC. The higher the NAC concentration, the greater the reduction was. | ||
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Online ISSN 1011-6575
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