| Title | Study of cognition versus thyrotropin in patients with Alzheimer’s disease | |
| Authors | Ioannis Ilias¹, Marina Boziki², Christodoulos S. Flordellis¹ and Magda Tsolaki²
1. Department of Pharmacology, Medical School, University of Patras, Rion, Greece 2. Third Department of Neurology, Medical School, Aristoteleian University, Thessaloniki, Greece |
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| Citation | Ilias, I., Boziki, M., Flordellis, C.S., Tsolaki, M.: Study of cognition versus thyrotropin in patients with Alzheimer’s disease, Epitheorese Klin. Farmakol. Farmakokinet. 20(2): 174-175 (2006) | |
| Publication Date | Accepted for publication: 19-20 May 2006 | |
| Full Text Language | English | |
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| Keywords | Alzheimer’s disease, humans, retrospective studies, thyroid function tests. | |
| Other Terms | review article | |
| Summary | We assessed cognitive changes (measured with the Mini-Mental Status Examination questionnaire; MMSEJ and baseline TSH levels in 17 patients treated with cholinesterase inhibitors (Group A), 16 patients treated with tacrine (Group B), 15 patients treated with various nootropics (Group C) and 53 patients under no systematic treatment (Group D). Only in Group A patients, a relation of yet-unknown pathophysiological significance could be suggested between TSH and the MMSE score after 4-8 months of treatment. | |
| References | 1. Kalmijn S., Mehta K.M., Pols H.A., Hofman A., Drexhage H.A., Breteler M.M.: Subclinical hyperthyroidism and the risk of dementia. The Rotterdam study. Clin. Endocrinol. 53: 733-737 (2000)
2. Lopez O., Huff F.J., Martinez A.J., Bedetti C.D.: Prevalence of thyroid abnormalities is not increased in Alzheimer’s disease. Neurobiol. Aging 10: 247-251 (1989) 3. Yoshimasu F., Kokmen E., Hay I.D., Beard C.M., 0fford K.P., Kurland L.T.: The association between Alzheimer’s disease and thyroid disease in Rochester, Minnesota. Neurology 41: 1745-1747 (1991) 4. Molchan S.E., Lawlor B.A., Hill J.L., Mellow A.M., Davis C.L., Martinez R., Sunderland T.: The TRH stimulation test in Alzheimer’s disease and major depression: relationship to clinical and CSF measures. Biol. Psychiatry 30: 567-576 (1991) 5. Kapaki E., Ilias I., Paraskevas G.P., Theotoka I., Christakopoulou I.: Thyroid function in patients with Alzheimer’s disease treated with cholinesterase inhibitors. Acta Neurobiol. Exp. 63: 389-392 (2003) 6. MacKhann G., Drachman D., Folstein M., Katzman R., Price D., Stadlan E.M.: Clinical diagnosis of Alzheimer’s disease. Report of the NINCDS-ADRDA work group under the auspices of the Department of Health and Human Services Task Force on Alzheimer’s disease. Neurology 34: 939-944 (1984) 7. Emilien G., Beyreuther K., Masters C.L., Maloteaux J.M.: Prospects for pharmacological intervention in Alzheimer disease. Arch. Neural. 57: 454-459 (2000) |
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| Relative Papers |
Online ISSN 1011-6575
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Articles published in this Journal are Indexed or Abstracted in: • Chemical Abstracts • Elsevier’s Bibliographic Databases: Scopus, EMBASE, EMBiology, Elsevier BIOBASE SCImago Journal and Country Rank Factor
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| ΕΤΗΣΙΑ ΣΥΝΔΡΟΜΗ 2006 – ANNUAL SUBSCRIPTION 2006 | |
| Γλώσσα Πλήρους Κειμένου – Full Text Language | Αγγλικά – English |
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