| Title | Effects of physical training on lipid peroxidation in patients on hemodialysis | |
| Authors | Ioannis Karamouzis¹, Athanasios Sioulis², Michael Karamouzis¹, Evangelia Koudi², Athanasios Triantos¹, Asterios Deligiannis³, Afroditi Dimitriadou¹ and Dimitrios Grekas²
1. Biochemistry Laboratory and 2. First Internal Medicine Department, 3. Sports Medicine Laboratory, Faculty of Medicine, Aristotle University, Thessaloniki, Greece |
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| Citation | Karamouzis, I., Sioulis, A., Karamouzis, M., Koudi, E., Triantos, A. et al: Effects of physical training on lipid peroxidation in patients on hemodialysis, Epitheorese Klin. Farmakol. Farmakokinet. 20(2): 198-200 (2006) | |
| Publication Date | Accepted for publication: 19-20 May 2006 | |
| Full Text Language | English | |
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| Keywords | Lipid peroxidation, Hemodialysis, exercise, F2-isoprostane. | |
| Other Terms | review article | |
| Summary | The 15-F2t-Isoprostane (15-F2t-Isop) is a characteristic F2-isoprostane which is produced in human cells via a free radical-catalysed lipid peroxidation mechanism of arachidonic acid, independent of cyclooxygenase pathway. Both human and experimental studies have indicated associations of 15-F2t-IsoP and severe inflammatory conditions, ischemia-perfusion, diabetes, atherosclerosis, renal failure, etc. Reports have shown that 15-F2t-IsoP is an authentic biomarker of lipid peroxidation and can be used as a potential in vivo indicator of oxidant stress in various clinical conditions, as well as in evaluation of antioxidants or drugs for their free radical-scavenging properties. In our previous studies we have demonstrated that the patients with chronic renal failure on hemodialysis (HD) have increased plasma levels of 15-F2t-IsoP as well as during dynamic muscle contractions in normal humans. From the other hand, it is known that exercise training programs appear to have beneficial morphological, functional and psychosocial effects in end-stage renal disease patients on hemodialysis. Having into consideration the above, we wanted to estimate the changes of free 15-F2t-IsoP at the plasma of patients on hemodialysis that were following a physical training program during hemodialysis. Our material consisted of 20 normal humans, 13 males and 7 females, aged 47.4±7.2 years old (N.H. group) and 28 patients on hemodialysis for years, who were separated into two groups, HD and HD/EXER. HD group consisted of 20 patients on hemodialysis, 13 males and 7 females, aged 55.8±10.5 years old and HD/EXER consisted of 8 patients, 5 males and 3 females, aged 60.1±9.8 years old that followed a program of physical training during hemodialysis. 15-F2t-IsoP levels were measured at the plasma of normal humans and patients with chronic renal failure (before and after hemodialysis) by the method of sensitive chromatographic enzymoimmunoassay method (EIA) with Cayman Chemical Company Kits. From our measurements it resulted that the program of physical training at renal disease patients on hemodialysis causes the decrease of lipid peroxidation. | |
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