| Title | Investigating geminin’s role in the immune system | |
| Authors | P. Kotantaki¹,², A. Garefalaki², C. Petropoulou¹, M. Tolaini², Z. Lygerou³, C. Flordellis¹, D. Kioussis² and S. Taraviras¹
1. Department of General Pharmacology, Medical School, Patras University, 26500 Rio, Patras, Greece 2. National Institute for Medical Research, Division of Molecular Immunology, The Ridgeway, Mill Hill, NW7 1AA London, UK 3. Department of General Biology, Medical School, Patras University, 26 500 Rio, Patras, Greece |
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| Citation | Kotantaki, P., Garefalaki, A., Petropoulou, C., Tolaini, M., Lygerou, Z. et al: Investigating geminin’s role in the immune system, Epitheorese Klin. Farmakol. Farmakokinet. 20(2): 216-219 (2006) | |
| Publication Date | Accepted for publication: 19-20 May 2006 | |
| Full Text Language | English | |
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| Keywords | Geminin, transgenic mice, T cell activation, lymphocytes, immune. | |
| Other Terms | review article | |
| Summary | Geminin is implicated in the processes of cell cycle regulation and differentiation. In the present study, we investigate geminin’s role in the immune system, since both hematopoiesis and activation of the peripheral leukocytes require highly controlled proliferation and differentiation events. We challenged T cells from lymph nodes and spleenic extracts with TCR-mediated stimuli and recorded a dramatic upregulation of geminin upon induction. Finally, we have used transgenesis in order to elaborate our knowledge on geminin’s in vivo role and study the effects of geminin’s in vivo overexpression. | |
| References | 1. Blow J.J., Dutta A.: Preventing re-replication of chromosomal DNA. Nat. Rev. Mol. Cell Biol. 6: 476-486 (2005)
2. Wohlschlegel J.A., Dwyer B.T., Dhar S.K., Cvetic C., Walter J.C., Dutta A.: Inhibition of eukaryotic DNA replication by geminin binding to Cdt1. Science 290: 2309-2312 (2000) 3. Tada S., Li A., Maiorano D., Mechali M., Blow J.J.: Repression of origin assembly in metaphase depends on inhibition of RLF-B/Cdt1 by geminin. Nat Cell Biol 3: 107-113 (2001) 4. Nishitani H., Taraviras S., Lygerou Z., Nishimoto T.: The human licensing factor for DNA replication Cdt1 accumulates in G1 and is destabilized after initiation of S-phase. J. Biol. Chem. 276: 44905-44911 (2001) 5. Arentson E., Faloon P., Seo J., et al.: Oncogenic potential of the DNA replication licensing protein CDT1. Oncogene 21: 1150-1158 (2002) 6. Seo J., Chung Y.S., Sharma G.G., et al.: Cdt1 transgenic mice develop lymphoblastic lymphoma in the absence of p53. Oncogene 24: 8176-8186 (2005) 7. Shreeram S., Sparks A., Lane D.P., Blow J.J.: Cell type-specific responses of human cells to inhibition of replication licensing. Oncogene 21: 6624-6632 (2002) |
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| Relative Papers |
Online ISSN 1011-6575
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Articles published in this Journal are Indexed or Abstracted in: • Chemical Abstracts • Elsevier’s Bibliographic Databases: Scopus, EMBASE, EMBiology, Elsevier BIOBASE SCImago Journal and Country Rank Factor
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