| Title | Hepatic regeneration after 60-70% and 30-34% partial hepatectomy in the rat | ||
| Authors | G.K. Papadimas1, K.N. Tzirogiannis1, M.D. Demonakou2, S.D. Skaltsas3, A.D. Grypioti1, K.T. Kourentzi1, K.N. Alexandropoulou1, K. Sourlis4, M.G. Mykoniatis1 and G.I. Panoutsopoulos1,4
1. Department of Experimental Pharmacology, Medical School, Athens University, Athens, Greece 2. Histopathology Laboratory, Sismanoglion G.D. Hospital, Marousi, Attiki, Greece 3. Patision General Hospital, Athens, Greece 4. Department of Physiotherapy, TEI Lamias, Greece |
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| Citation | Papadimas, G.K, Tzirogiannis, K.N., Demonakou, M.D., Skaltsas, S.D., Grypioti, A.D., et al.: Hepatic regeneration after 60-70% and 30-34% partial hepatectomy in the rat, Epitheorese Klin. Farmakol. Farmakokinet. 22(2): 267-268 (2008) | ||
| Publication Date | 23-25 May 2008 | ||
| Full Text Language | English | ||
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| Keywords | Ki67, liver regeneration, mitosis, partial hepatectomy, PCNA. | ||
| Other Terms | Review article | ||
| Summary | Liver regeneration was studied after 30-34% and 60-70% partial hepatectomy in the rat liver. The rate of [3H]-thymidine incorporation into hepatic DNA, liver thymidine kinase activity, proliferating cell nuclear antigen (PCNA) and Ki67 immunochemical detection as well as the mitotic index in HE stained sections were used as indices of liver regeneration. Liver regeneration peaked between 24 and 48 h after 60-70% partial hepatectomy and at 54-60 h after 30-34% partial hepatectomy. Ki67 immunochemical detection closely correlated with [3H]-thymidine incorporation into hepatic DNA, making this index a reliable indicator of the S phase of the cell cycle. Major discrepancy was observed between PCNA immunostaining and the rest of regenerative indices delineating the fact that PCNA may be inappropriate as an index of liver regeneration at lower degrees of partial hepatectomy. In conclusions, the findings of this study indicate an asynchronous entry of hepatocytes into the S phase of the cell cycle despite G1 phase progression after 30-34% partial hepatectomy as compared to 60-70% partial hepatectomy. | ||
| References | 1. Fausto N.: Liver regeneration. J. Hepatol. 32(1 suppl): 19-31 (2000)
2. Fausto N., Laird A.D., Webber E.M.: Liver regeneration. 2. Role of growth factors and cyteration. FASEB J. 9: 1527-1536 (1995) 3. Michalopoulos G.K.: Liver regeneration. J. Cell Physiol. 213: 286-300 (2007) 4. Michalopoulos G.K., DeFrances M.C.: Liver regeneration. Science 276 (5309): 60-66 (1997) 5. Ankoma-Sey V.: Hepatic regeneration- revisiting the myth of Prometheus. News Physiol. Sci. 14: 149-155 (1999) |
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Online ISSN 1011-6575
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Articles published in this Journal are Indexed or Abstracted in: • Chemical Abstracts • Elsevier’s Bibliographic Databases: Scopus, EMBASE, EMBiology, Elsevier BIOBASE SCImago Journal and Country Rank Factor
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