Τόμος 22 (2008) – Τεύχος 2 – Άρθρο 83 – Επιθεώρηση Κλινικής Φαρμακολογίας και Φαρμακοκινητικής-Διεθνής Έκδοση – Volume 22 (2008) – Issue 2 – Article 83 – Epitheorese Klinikes Farmakologias και Farmakokinetikes-International Edition

1. Department of Pharmacology, Medical School, Aristotle University of Thessaloniki, Greece

2. Department of Pharmacology, Faculty of Medicine and Public Health, University of Verona, Italy

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Methods: 2 South European countries participated in the study: Greece and Italy. Conformance to the recommended guidelines and quality of perioperative chemoprophylaxis were checked by use of the same questionnaire in each country. The following criteria of quality in chemoprophylaxis were checked: 1) application of chemoprophylaxis, 2) duration and time of initiation of chemoprophylaxis and 3) the kind of antibiotics used.

Results: Parenteral chemoprophylaxis was applied in all operations in both countries, was usually initiated during preinduction to anesthesia and its duration exceeded 24 hours in most cases. 2^nd generation cephalosporins (ATC code J01DC), vancomycin (ATC code J01XA01), metronidazole (ATC code J01XD01) and amikacin (ATC code J01GB06) were used in Greece. In Italy, teicoplanin (ATC code J01XA02), vancomycin (ATC code J01XA01), cefazolin (ATC code J01DB04) and amoxycillin clavulanate (ATC code J01CR02) were used.    

Conclusions: The quality of perioperative chemoprophylaxis was not satisfactory, and serious inconsistencies to the recommended guidelines were observed in many cases. Dynamic changes are required in order to improve the quality and establish a successful and evidence-based perioperative chemoprophylaxis in Orthopedics Surgery.

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