| Title | The expression of the Corticotropin Releasing Factor (CRF) system of neuropeptides and receptors in mouse microglia cells | ||
| Authors | E. Polakis1, M. Lambropoulou2, C. Charsou1, C. Cheimonidou1, K. Chalkiadaki1 and E. Chatzaki1
1. Laboratory of Pharmacology and 2. Laboratory of Histology, Faculty of Medicine, Democritus University of Thrace, Alexandroupolis, Greece |
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| Citation | Polakis, E., Lambropoulos, M., Charsou, C., Cheimonidou, C., Chalkiadaki, K. et al.: The expression of the Corticotropin Releasing Factor (CRF) system of neuropeptides and receptors in mouse microglia cells, Epitheorese Klin. Farmakol. Farmakokinet. 22(2): 297-299 (2008) | ||
| Publication Date | 23-25 May 2008 | ||
| Full Text Language | English | ||
| Order – Buy | Ηλεκτρονική Μορφή: pdf (10 €) – Digital Type: pdf (10 €)
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| Keywords | Corticotropin Releasing Factor, urocortin, receptor, microglia, mouse. | ||
| Other Terms | Review article | ||
| Summary | The CRF system is the key mediator of the stress response in the CNS and in the periphery. Expression of CRF neuropeptides and binding sites was examined in mouse microglial cells. Indirect immunofluorescence revealed the presence of immunoactive CRF and urocortin 1 in the cytoplasm, whereas both their receptors CRF1 and CRF2 were found in the cell membrane of the mouse microglial cell line BV-2. These results were confirmed by RT-PCR. The concomitant presence of the receptors with their neuropeptide ligands implies an autocrine role of the CRF system in microglial cells. | ||
| References | 1. Dautzenberg F.M., Hauger R.L.: The CRF peptide family and their receptors: yet more partners discovered. Trends Pharmacol. Sci. 23: 71-77 (2002)
2. Zobel A.W., Nickel T., Kunzel H.E., Ackl N., Sonntag A., Ising M., Holsboer F.: Effects of the high-affinity corticotropin-releasing hormone receptor 1 antagonist R121919 in major depression: the first 20 patients treated. J. Psychiatr. Res. 34: 171-181 (2000) 3. Chatzaki E., Minas V., Zoumakis E., Makrigiannakis A.: CRF receptor antagonists: utility in research and clinical practice. Curr. Med. Chem. 13: 2751-2760 (2006) 4. Ock J., Lee H., Kim S., Lee W.H., Choi D.K., Park E.J., Kim S.H., Kim I.K., Suk K.: Induction of microglial apoptosis by corticotropin-releasing hormone. J. Neurochem. 98: 962-972 (2006) 5. Blasi, E., Mazzolla, R., Barluzzi, R., Mosci, P., Bartoli, A. & Bistoni, F.: Intracerebral transfer of an in vitro established microglial cell line: local induction of a protective state against lethal challenge with Candida albicans. J. Neuroimmunol. 32: 249-257 (1991) 6. Chatzaki E., Murphy B.J., Wang L., Million M., Ohning G.V., Crowe P.D., Petroski R., Tache Y., Grigoriadis D.E.: Differential profile of CRF receptor dist ribution in the rat stomach and duodenum assessed by newly developed CRF receptor antibodies. J. Neurochem 88: 1-11 (2004) 7. Chatzaki E., Crowe P.D., Wang L., Million M., Tache Y., Grigoriadis D.E.: CRF receptor type 1 and 2 expression and anatomical distribution in the rat colon. J. Neurochem. 90: 309-316 (2004) |
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| Relative Papers | |||
Online ISSN 1011-6575
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Articles published in this Journal are Indexed or Abstracted in: • Chemical Abstracts • Elsevier’s Bibliographic Databases: Scopus, EMBASE, EMBiology, Elsevier BIOBASE SCImago Journal and Country Rank Factor
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