Τόμος 22 (2008) – Τεύχος 2 – Άρθρο 109 – Επιθεώρηση Κλινικής Φαρμακολογίας και Φαρμακοκινητικής-Διεθνής Έκδοση – Volume 22 (2008) – Issue 2 – Article 109 – Epitheorese Klinikes Farmakologias και Farmakokinetikes-International Edition

Title The introduction of the use of stimulants for attention deficit and hyperactivity in children (and adolescents)
Authors B. Tsakmaki and G. Papadopoulos

Laboratory of Pharmacology, Medical School, University of Athens, Greece

Citation Tsakmaki, B., Papadopoulos, G.: The introduction of the use of stimulants for attention deficit and hyperactivity in children (and adolescents), Epitheorese Klin. Farmakol. Farmakokinet. 22(2): 344-346 (2008)
Publication Date 23-25 May 2008
Full Text Language English
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Keywords Attention deficit hyperactivity disorder (ADHD), stimulants, Charles Bradley, benzedrine, dexendrine.
Other Terms Review article
Summary The clinical use of stimulants for behavioral disturbances in children and adolescents first began in 1937 by Charles Bradley and was based on an accidental observation of him, when giving Benzedrine to brain-diseased children, which resulted in an improvement in their disruptive behaviors. Bradley also noted improved academic performance, better self-control, and improved attention to task. Bradley and his collaborators continued to investigate more carefully the effects of Benzedrine and Dexedrine, also by using various psychometric tests. Bradley published a completed form of his his findings in 1950 after using amphetamines for two decades to treat hyperactivity, impulsivity, and moodiness in clinically referred children.
References 1. Barkley R.A.: Attention Deficit Hyperactivity Disorder: A Handbook of Diagnosis & Treatment. Pp. 3-38, 573-612. The Guilford Press, New York, 1996

2. Bradley C.: The behavior of children receiving Benze-drine. Am. J. Psychiatry 94: 577-585 (1937)

3. Bradley C., Bowen M.: School performance of children receiving amphetamine (benzedrine) sulfate. Am. J. Orthopsychiatry X: 782-788 (1940)

4. Bradley C., Green E.: Psychometric performances of children receiving amphetamine (Benzedrine) Sulfate. Am. J. Psychiatry 97: 388-394 (1941)

5. Bradley C.: Benzedrine and dexedrine in the treatment of children’s behavior disorders. Pediatrics 5:  24-27 (1950)

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