| Title | Pregabalin as a new treatment strategy for neuropathic pain in spinal cord injury: an evidence based evaluation | ||
| Authors | Th. Tzellos, G. Papazisis, E. Amaniti, Ch. Sardeli, Ch.Pourzitaki, D. Tahmatzidis and D. Kouvelas
Department of Pharmacology, School of Medicine, Aristotle University of Thessaloniki, Greece |
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| Citation | Tzellos, T., Papazisis, G., Amaniti, E., Sardeli, C., Pourzitaki, C. et al.: Pregabalin as a new treatment strategy for neuropathic pain in spinal cord injury: an evidence based evaluation, Epitheorese Klin. Farmakol. Farmakokinet. 22(2): 355-357 (2008) | ||
| Publication Date | 23-25 May 2008 | ||
| Full Text Language | English | ||
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| Keywords | Lyrica, neuropathic pain, pregabalin, spinal cord injury. | ||
| Other Terms | Review article | ||
| Summary | Spinal cord injury (SCI) is a leading cause of neuropathic pain (NP). NP in SCI patients causes physical discomfort and depressive symptoms leading to greater pain intensity and interference with daily activities. Unfortunately it is quite refractory and current treatments are not effective. Searching of effective treatments is a high priority. One promising option is pregabalin (PG), with few side effects and mechanism of action which could explain its efficacy in NP of SCI. However, evidence is still controversial. In order to efficiently integrate valid information and provide basis for rational decision making through determining PG efficacy in treating NP in SCI, the literature was systematically reviewed. Medline, Embase, CINAHL and Cochrane Database were searched for eligible studies for inclusion in this review using search terms “pregabalin”, “lyrica”, “neuropathic pain” and “spinal cord injury”. Studies were assessed independently by two authors. Two studies were eligible for inclusion. PG appears to be efficacious for NP in SCI. However, its use is accompanied by some serious side effects. This systematic review indicated the efficacy of PG in NP of SCI. Dosing may play important role. Since PG is expensive, cost effectiveness studies should be performed. Recommendations for future research to form clinical practice should include dose response analysis, in order to determine the schema employed and the duration of treatment. | ||
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| Relative Papers | |||
Online ISSN 1011-6575
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Articles published in this Journal are Indexed or Abstracted in: • Chemical Abstracts • Elsevier’s Bibliographic Databases: Scopus, EMBASE, EMBiology, Elsevier BIOBASE SCImago Journal and Country Rank Factor
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