Τόμος 20 (2006) – Τεύχος 2 – Άρθρο 74 – Επιθεώρηση Κλινικής Φαρμακολογίας και Φαρμακοκινητικής-Διεθνής Έκδοση – Volume 20 (2006) – Issue 2 – Article 74 – Epitheorese Klinikes Farmakologias και Farmakokinetikes-International Edition

Title The effect of raroxetine on blood glucose level via serotonergic  mechanisms
Authors Efnan Muci¹, Cunay Ulku¹, Murat Kesim¹, Mine Kadioglu¹, Erdem Duman², Nuri I. Kalyoncu¹ and Ersin Yaris¹

1. Department of Pharmacology,

2. Department of Anesthesiology, School of Medicine, Karadeniz Technical University, TURKEY

Citation Muci, E., Ulku, C., Kesim, M., Kadioglu, M., Duman, E. et al: The effect of raroxetine on blood glucose level via serotonergic  mechanisms, Epitheorese Klin. Farmakol. Farmakokinet. 20(2): 259-260 (2006)
Publication Date Accepted for publication: 19-20 May 2006
Full Text Language English
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Keywords Paroxetine, blood glucose level, insulin, serotonin.
Other Terms review article
Introduction Selective serotonin re-uptake inhibitors (SSRI) are preferentially used in the treatment of some psychiatric diseases, like depression, panic disorder, obsessive compulsive disorder. They show their effects on central nerve system by increasing the amount of serotonin via inhibiting its re-uptake in the synapses. But it is not known whether this is valid for the peripheral systems.
References 1. Davis S.N.: Insulin, oral hypoglycemic agents, and the pharmacology of the endocrine pancreas. In: (Brunton L.L., Lazo J.S., Parker K.L., eds) Goodmann & Gilman’s, The Pharmacological Basis of Therapeutics. Eleventh Edition, pp. 1613-1645, Mc Graw Hill Companies, USA 2006

2. Kesim M., Duman E.N., Kad1oglu M., Ulku C., Muci E., Kalyoncu N.I., Yaris E.: Antinociceptive effects of fluoxetine and paroxetine with their related actions on glycemia in mice. Neuro. Endocrinol. Lett: 2006 (in press)

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