| Title | Metabolism of aromatic aldehydes by aldehyde oxidizing enzymes: contribution of aldehyde oxidase | |
| Author | Georgios I. Panoutsopoulos
Department of Experimental Pharmacology, Medical School, Athens University, Athens, Greece |
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| Citation | Panoutsopoulos, G.I.: Metabolism of aromatic aldehydes by aldehyde oxidizing enzymes: contribution of aldehyde oxidase, Epitheorese Klin. Farmakol. Farmakokinet. 20(2): 270-272 (2006) | |
| Publication Date | Accepted for publication: 19-20 May 2006 | |
| Full Text Language | English | |
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| Keywords | Allopurinol, disulfiram, isovanillin, protocatechuic aldehyde, vanillin. | |
| Other Terms | review article | |
| Summary | Aldehydes are highly reactive organic compounds, which occur as natural constituents in a wide variety of foods. In addition, biogenic amines and many drugs with an amino group can be transformed into aldehydes via the action of monoamine oxidase. Oxidation of aldehydes to their acids is usually ascribed to aldehyde dehydrogenase, whereas the contribution of aldehyde oxidase and xanthine oxidase is ignored. The present investigation compares the relative contribution of the enzymes aldehyde dehydrogenase, aldehyde oxidase and xanthine oxidase in the oxidation of vanillin, isovanillin and protocatechuic aldehyde both in the absence/presence of specific inhibitors for each enzyme, in separate preparations. The inhibitors used were isovanillin for aldehyde oxidase, allopurinol for xanthine oxidase and disulfiram for aldehyde dehydrogenase. Vanillin was rapidly oxidized by aldehyde oxidase, isovanillin was predominantly metabolized by aldehyde dehydrogenase and protocatechuic aldehyde was slowly oxidized by all three enzymes. Thus, aldehyde oxidase may be a significant factor in the oxidation of aromatic aldehydes generated from amines and alkyl benzenes during drug metabolism, as well as in the catabolism of biogenic amines such as dopamine, homovanillamine and noradrenaline. | |
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Online ISSN 1011-6575
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