| Title | The potential involvement of ribosomal protein S5 in the initiation of MEL erythroid cell differentiation and apoptosis | |
| Author | Eleni T. Papachristou¹, Christina Matragkou¹, Ioanna N. Triviai², Sotirios S. Tezias², Asterios S. Tsiftsoglou², Theodora Choli-Papadopoulou¹ and Ioannis S. Vizirianakis²
1. Laboratory of Biochemistry, School of Chemistry and 2. Laboratory of Pharmacology, Department of Pharmaceutical Sciences, Aristotle University of Thessaloniki, GR-54124 Thessaloniki, Greece |
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| Citation | Papachristou, E.T., Matragkou, C., Triviai, I.N., Tezias, S.S., Tsiftsoglou, A.S. et al: The potential involvement of ribosomal protein 85 in the initiation of MEL erythroid cell differentiation and apoptosis, Epitheorese Klin. Farmakol. Farmakokinet. 20(2): 276-278 (2006) | |
| Publication Date | Accepted for publication: 19-20 May 2006 | |
| Full Text Language | English | |
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| Keywords | Ribosomal protein S5, MEL cell differentiation, apoptosis, gene expression, flow cytometry analysis, annexin staining. | |
| Other Terms | review article | |
| Summary | Ribosomal proteins are considered integral structural components of ribosomes contributing to protein synthesis. Evidence now exists to indicate that several ribosomal proteins can also regulate specific cellular processes, suggesting that these proteins can act as multi-functional entities. Previously, we have studied the potential functional role of mouse ribosomal protein S5 (rpS5) in erythroid differentiation of murine erythroleukemia (MEL) cells by establishing permanent cell lines via stable transfection of mouse rpS5 cDNA and expression of rpS5 gene constitutively. MEL cells transfected with rpS5 cDNA exhibited a delay in the onset of erythroid differentiation program. In this study, we extended these observations and applied flow cytometry to investigate the potential role of rpS5 in apoptosis of differentiating MEL cells. | |
| References | 1. Tsiftsoglou A.S., Pappas I.S., Vizirianakis I.S.: The developmental program of murine erythroleukemia cells. Oneal. Res. 13: 339-346 (2003)
2. Tsiftsoglou A.S., Pappas I.S., Vizirianakis I.S.: Mechanisms involved in the induced differentiation of leukemia cells. Pharmaeal. Ther. 100: 257-290 (2003) 3. Vizirianakis I.S., Pappas I.S., Gougoumas D.D., Tsiftsoglou A.S.: Expression of ribosomal protein S5 cloned gene during differentiation and apoptosis in murine erythroleukemia (MEL) cells. Oneal. Res. 11: 409-419 (1999) 4. Wool I.G., Chan Y.L, Gluck A.: Cell Bial. 73: 933-947 (1995) |
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| Relative Papers |
Online ISSN 1011-6575
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Articles published in this Journal are Indexed or Abstracted in: • Chemical Abstracts • Elsevier’s Bibliographic Databases: Scopus, EMBASE, EMBiology, Elsevier BIOBASE SCImago Journal and Country Rank Factor
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