| Title | Non-adrenergic non-cholinergic relaxing effect of theophylline on the oesophagus and the lower oesophageal sphincter of the rabbit | |
| Authors | Theophano A. Psarra¹, Georgios C. Batzias¹, Theo L. Peeters² and Maria Koutsoviti-Papadopoulou¹
1. Laboratory of Pharmacology, Veterinary Faculty, Aristotle University, Thessaloniki, Greece 2. Gut Peptide Laboratory, Faculty of Medicine, University of Leuven, Belgium |
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| Citation | Psarra, Th.A., Batzias, G.C., Peeters, Th.L., Koutsoviti-Papadopoulou, K.: Non-adrenergic non-cholinergic relaxing effect of theophylline on the oesophagus and the lower oesophageal sphincter of the rabbit, Epitheorese Klin. Farmakol. Farmakokinet. 20(2): 305-307 (2006) | |
| Publication Date | Accepted for publication: 19-20 May 2006 | |
| Full Text Language | English | |
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| Keywords | Oesophagus, LOS, theophylline, PDE inhibitors, NANC (non-adrenergic, non-cholinergic), rabbit. | |
| Other Terms | review article | |
| Summary | The present study examines the effect of the widely used bronchodilator drug theophylline, a non-specific phosphodiesterase (PDE) inhibitor, on the rabbit oesophagus and lower oesophageal sphincter (LOS) contractility, and explores the mechanism of its action. According to the results theophylline, at concentrations higher than 3×10-5 M produces a concentration-dependent decrease in the tone and/or the phasic contractions of the rabbit oesophagus and LOS. This effect is not antagonised by adrenergic and cholinergic antagonists or by the ganglion-blocker hexamethonium (HEX), suggesting that it is non-adrenergic, non-cholinergic (NANG) and post-synaptic. In addition, L-NAME, an inhibitor of nitric oxide synthetase, fails to modify the theophylline’s relaxing effect. In conclusion, theophylline, at quite high concentrations, produces a post-synaptic, concentration-dependent NANG decrease in the tone and/or the phasic contractions of the rabbit oesophagus and LOS. There is evidence to suggest that this relaxing effect is due to cAMP elevation mediated through the inhibitory action of theophylline on the PDEs present in the LOS and oesophagus tissues. | |
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| Relative Papers |
Online ISSN 1011-6575
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Articles published in this Journal are Indexed or Abstracted in: • Chemical Abstracts • Elsevier’s Bibliographic Databases: Scopus, EMBASE, EMBiology, Elsevier BIOBASE SCImago Journal and Country Rank Factor
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