| Title | Alterations of the expression of CD34 during the evolution of sepsis by ventilator-associated pneumonia | |
| Authors | Aikaterini-Christina Tampaki¹, Thomas Tsaganos², Aikaterini Spyridaki², Basiliki Karagianni², Evangelos J. Giamarellos-Bourboulis², Helen Giamarellou², Diamantis Plachouras² and Nikolaos Drakoulis¹
1. Department of Pharmaceutical Technology, School of Pharmacy, and 2. 4th Department of Internal Medicine, National and Kapodistrian University of Athens, Athens, Greece |
|
| Citation | Tampaki, A.-C., Tsaganos, Th., Spyridaki, A., Karagianni, B., Giamarellos-Bourboulis, E.J. et al: Alterations of the expression of CD34 during the evolution of sepsis by ventilator-associated pneumonia, Epitheorese Klin. Farmakol. Farmakokinet. 20(2): 328-330 (2006) | |
| Publication Date | Accepted for publication: 19-20 May 2006 | |
| Full Text Language | English | |
| Order – Buy | Ηλεκτρονική Μορφή: pdf (10 €) – Digital Type: pdf (10 €)
pharmakonpress[at]pharmakonpress[.]gr |
|
| Keywords | Stem cells, sepsis, ventilator-associated pneumonia, cytokines. | |
| Other Terms | review article | |
| Summary | In order to define the role of haematopoietic stem cells (HSC) in the evolution of septic syndrome caused by ventilator-associated pneumonia (VAP) the alterations of the expression of CD34 a prospective study was designed with 43 patients with septic syndrome by ventilator-associated pneumonia. Blood was sampled on day of enrollment and on days 3, 5, and 7 thereafter and percentage and absolute values of CD34 and concentrations of tumour necrosis factor-alpha, interleukin-6 (IL-6), IL-8 and malondialdehyde (MDA) were estimated. No differences were found either in percentage and absolute numbers of CD34, or in concentrations of TNFa, IL-6, IL-8, and MDA among patients with sepsis, severe sepsis and septic shock. No differences were found between the concentrations of TNFa and MDA in the days sampled, whereas CD34 percentage was elevated on day 7 compared to day 1, IL-6 on days 1 and 3 was lower than day 7, and IL-8 was higher in day 5 than day 1. A positive correlation was also revealed between IL-6 on day 1 and CD34 percentage on day 5, between CD34 percentage on day 1 and IL-6 on day 7, and between absolute CD34 count on day 1 and IL-8 on day 3. It is concluded that CD34 HSC play a significant role in the evolution of sepsis by VAP by regulating production of white blood cells and of cytokines. In addition, CD34 expression is influenced by the levels of cytokines in blood. | |
| References | 1. Bonnet D.: Haematopoietic stem cells. J. Pathol. 197: 430- 40 (2002)
2. Bonnet D.: Haematopoietic stem cells. Birth Defects Res. C. Embryo Today 69: 219-29 (2003) 3. Hotchkiss R.S., Tinsley K.W., Karl I.E.: Role of apoptotic cell death in sepsis. Scand. J. Infect. Dis. 35: 585-593 (2003) 4. Hotchkiss R.S., Tinsley K.W., Swanson P.E., Schmieg R.E., Hui J.J., Chamg K.C., et al.: Sepsis-induced apoptosis causes progressive profound depletion of B and CD4+ T lymphocytes in humans. J. Immunol. 166: 6952-6963 (2001) 5. Levy M., Fink M.P., Marshall J.C., et al.: 2001 SCCM/ESICM/ACCP/ATS/SIS international sepsis definitions conference. Crit. Care Med. 31: 1250-1256 (2003) 6. Rodriguez Mdel C., Bernad A., Aracil M.: Interleukin-6 deficiency affects bone marrow stromal precursors, resulting in defective haematopoietic support. Blood 103: 3349-3354 (2004) 7. Peters M., Solem F., Goldschmidt J., Schirmacher P., Rose-John S.: Interleukin-6 and the soluble interleukin-6 receptor induce stem cell factor and Flt-3L expression in vivo and in vitro. Exp. Hematol. 29: 146-155 (2001) 8. Jansen J.H., Kluin-Nelemans J.C., Van Damme J., Wientjens G.J., Willemze R., Fibbe W.E.: Interleukin 6 is a permissive factor for monocytic colony formation by human haematopoietic progenitor cells. J. Exp. Med. 175: 1151-4 (1992) 9. Santiago-Schwarz F., Tucci J., Carsons S.E.: Endogenously produced interleukin 6 is an accessory cytokine for dendritic cell haematopoiesis. Stem Cells 14: 225-31 (1996) |
|
| Relative Papers |
Online ISSN 1011-6575
Άρθρα Δημοσιευμένα σε αυτό το Περιοδικό Καταχωρούνται στα:
- Chemical Abstracts
- Elsevier’s Bibliographic Databases: Scopus, EMBASE, EMBiology, Elsevier BIOBASE SCImago Journal and Country Rank Factor
Articles published in this Journal are Indexed or Abstracted in: • Chemical Abstracts • Elsevier’s Bibliographic Databases: Scopus, EMBASE, EMBiology, Elsevier BIOBASE SCImago Journal and Country Rank Factor
Συντακτικη Επιτροπή-Editorial Board
| ΕΤΗΣΙΑ ΣΥΝΔΡΟΜΗ 2006 – ANNUAL SUBSCRIPTION 2006 | |
| Γλώσσα Πλήρους Κειμένου – Full Text Language | Αγγλικά – English |
| Παραγγελία – Αγορά – Order – Buy | Ηλεκτρονική Μορφή: pdf (70 €) – Digital Type: pdf (70 €)
pharmakonpress[at]pharmakonpress[.]gr |
| Έντυπη Μορφή (70 € + έξοδα αποστολής) – Printed Type (70 € + shipping)
pharmakonpress[at]pharmakonpress[.]gr |
|