| Title | Survival and differentiation of transplanted neural stem cells in the striatum of a mouse model of Parkinson’s disease | |
| Authors | Despoina Ziavra¹, Ioannis Nestoras¹, Georgia Makri⁴, Panagiotis Giompres², Stavros Taraviras³, Lazaros Triarhou⁵, Ada Mitsacos¹, Dimitra Thomaidou⁴, Rebecca Matsas⁴ and Elias Kouvelas6
Departments of 1. Physiology and 3. Pharmacology Faculty of Medicine, 2. Laboratory of Human and Animal Physiology, Department of Biology, University of Patras, Patra 4. Hellenic Pasteur Institute, Athens 5. Department of Educational and Social Politics, University of Macedonia, Thessaloniki, Greece 6. Cozzika Foundation, Athens, Greece |
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| Citation | Ziavra, D., Nestoras, I., Makri, G., Giompres, P., Taraviras, S. et al: Survival and differentiation of transplanted neural stem cells in the striatum of a mouse model of Parkinson’s disease, Epitheorese Klin. Farmakol. Farmakokinet. 20(2): 359-362 (2006) | |
| Publication Date | Accepted for publication: 19-20 May 2006 | |
| Full Text Language | English | |
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| Keywords | Neural stem cells, Parkinson’s disease, 6-0HDA, mouse model, transplantation. | |
| Other Terms | review article | |
| Summary | Neural transplantation strategy is based on the idea that dopaminergic neurons or neuroblasts can be used to replace the nigral dopaminergic neurons that are degenerated in patients with PD. In the present study both enhanced green fluorescent protein (GFP)-modified and BMBB-GFP- modified neural stem cells (NCS) were used. Aim of our study was to demonstrate that these cells can survive, differentiate and functionally integrate into host tissue in the 6-hydroxydopamine mouse model of Parkinson’s disease. Animals received unilateral stereotaxic injections of 6-OHDA into the nigrostriatal tract. After lesioning, mice received unilateral intrastriatal injections of neurosphere cell suspensions. We demonstrate that GFP positive NCS developed neuronal phenotype of TH poitive and striatal medium spiny neurons. BM88-modified cells differentiated mainly into striatal medium spiny neurons. | |
| References | 1. Sonntag K.C., Simantov R., Isacson O.: Stem cells may reshape the prospect of Parkinson’s disease therapy. Molecular Brain Res. 134: 34-51 (2005)
2. Iancu R., Mohapel P., Brundin P., Paul G.: Behavioural characterization of a unilateral 6-OHDA-lesion model of Parkinson’s disease in mice. Behav. Brain Res. 162: 1-10 (2005) 3. Meissner K.K., Kirkham D.L., Doering L.C.: Transplants of neurosphere cell suspensions from aged mice are functionalin the mouse model of Parkinson’s. Brain Res. 1057(1-2): 105- 112 (2005) 4. Bjorklund L.M., Sanchez-Pernaute R., Chung S., Andersson T., Chen I.Y., McNaught K.S., Brownell A.L., Jenkins B.G., Wahlestedt C., Kim K.S., Isacson O.: Embryonic stem cells develop into functional dopaminergic neurons after transplantation in a Parkinson rat model. PNAS 99: 2344-2349 (2002) 5. Yang M., Stull N.D., Berk M.A., Snyder E.Y., Iacovitti L.: Neural Stem Cells Spontaneously Express Dopaminergic Traits after Transplantation into the intact or 6- Hydroxydopamine-Lesioned Rat. Exper. Neurol. 177: 0-60 (2002) |
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Online ISSN 1011-6575
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Articles published in this Journal are Indexed or Abstracted in: • Chemical Abstracts • Elsevier’s Bibliographic Databases: Scopus, EMBASE, EMBiology, Elsevier BIOBASE SCImago Journal and Country Rank Factor
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