| Title | The role of oxygen free radicals in ischaemia: reperfusion during carotid endarterectomy | |
| Authors | Vassilios Papavassiliou¹, Kiriaki Vourdami², Dimitrios Dimitroulis², Despina Perrea³ and Christos Liapis⁴
1. Department of Vascular Surgery, Sismanoglio General Hospital, Athens, Greece 2. 2nd Department of Propedeutic Surgery, Medical School, Laiko Hospital, Athens University, Athens, Greece 3. Laboratory for Experimental Surgery and Surgical Research N.S. Christeas, Athens, Greece 4. Department of Vascular Surgery, Medical School, Athens University, Attikon University Hospital, Athens, Greece |
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| Citation | Papavassiliou, V., Vourdami, K., Dimitroulis, D., Perrea, D., Liapis, Ch.: The role of oxygen free radicals in ischaemia: reperfusion during carotid endarterectomy, Epitheorese Klin. Farmakol. Farmakokinet. 25(2): 47-53 (2011) | |
| Publication Date | Accepted for publication (Final version): July 1, 2011 | |
| Full Text Language | English | |
| Order – Buy | Ηλεκτρονική Μορφή: pdf (10 €) – Digital Type: pdf (10 €)
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| Keywords | Carotid endarterectomy, malondialdehyde (MDA), cerebral ischemia, free radicals. | |
| Other Terms | review article | |
| Summary | Carotid Endarterectomy is associated with a perioperative risk of stroke of about 3-6% which is attributed either to embolization of atheromatous plaque or reduced blood flow. The objective of this study is to estimate free radical formation during carotid endarterectomy (CEA) and to investigate the impact on the above procedure of bilateral carotid stenosis, reperfusion, and duration of carotid cross clamping and history of stroke. Thirty one consecutive patients who underwent elective CEA were prospectively included in the study. All of the patients were evaluated preoperatively with a complete medical history and a conventional digital substruction angiography and/or a carotid colour duplex ultrasound. All patients were assigned into three groups according to the degree of contralateral carotid stenosis and into two groups according to their neurological history (symptomatic – asymptomatic). Blood was sampled at several phases during CEA in order to estimate changes in malondialdehyde concentration. None of the patients developed any clinically detectable neurological deficit postoperatively. On application of carotid cross clamp the absolute value of malondialdehyde concentration rise. At the end of operation patients without a history of stroke had significantly lower malondialdehyde values compared with those patients who sustained a stroke or TIA in the past. Significant changes in the concentration of malondialdehyde values were recorded during CEA indicating free radical formation. This malomdialdehyde concentration is independent of the duration of carotid cross clamping, but depends on the preoperative neurological status of the patient and the degree of contralateral carotid stenosis. | |
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