| Title | The clinical symptoms of the skin from the effects of environmental pollutants | |
| Authors | E. Mikelatou, V. Gardiki and A. Tsigonia
Department of Aesthetics and Cosmetology, School of Health and Caring Professions, Technological Educational Institution of Athens, Egaleo, Athens, Hellas |
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| Citation | Mikelatou, E., Gardiki, V., Tsigonia, A.: The clinical symptoms of the skin from the effects of environmental pollutants, Epitheorese Klin. Farmakol. Farmakokinet. 25(2): 105-110 (2011) | |
| Publication Date | Accepted for publication (Final version): July 1, 2011 | |
| Full Text Language | English | |
| Order – Buy | Ηλεκτρονική Μορφή: pdf (10 €) – Digital Type: pdf (10 €)
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| Keywords | Dioxins, organochlorine compounds, food chain, bioconcentration, endocrine disruptors, chloracne, porfyria cutanea, tarda, hyperpingmentation, hypertrixosis, onycholysis. | |
| Other Terms | review article | |
| Summary | Dioxins, a group of organic chemical substances are considered to be amongst the most Persistent Organic Pollutants (POPs) because of their high toxicity and stability. They are produced as subproducts in the chlorine industry. Dioxins are hydrophilic/lipophilic substances. They are bioaccumulated in the lipid tissue of fish and animals. The destruction of dioxins is an extremely slow process. Dioxins fall in the category of endocrine disruptors. Exposure to dioxins leads to their absorption through the body’s major uptake pathways, the respiratory system, the gastrointestinal, the skin, the in uterus exposure, the infantile (through nursing), childhood and puppetry. Dioxins are potential mutagenic and carcinogenic substances. The effects on humans depend on the exposure’s duration and dose, as well as on whether the exposure is acute or chronic. The toxicity of dioxins can potentially lead to: chloracne, diabetes II, developmental, learning and neurological problems, reproduction and endocrine dis-orders, a 40% increase of cancer appearance, teeth decalcification, headaches and potential trans-mutation. Chloracne is a rare type of acne, which is caused by organochlorine compounds and works as a biomarker for dioxins exposure. It appears after a direct skin exposure to dioxins, even though absorption mechanism and aspiration is also possible. | |
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