| Title | Long term efficacy, tolerance and safety of liposo mal amphotericin b in children with CNS aspergil losis and acute lymphoblastic leukemia | |
| Author | F. Athanasiadou, A. Tragiannidis, Th. Papageorgiou and M. Stamou | |
| Citation | Athanasiadou, F., Tragiannidis, A., Papageorgiou, T. and Stamou, M.: Long term efficacy, tolerance and safety of liposo mal amphotericin b in children with CNS aspergil losis and acute lymphoblastic leukemia, Epitheorese Klin. Farmakol. Farmakokinet. 18(1): 85-87 (2004) | |
| Publication Date | Accepted for publication: 2004 | |
| Full Text Language | English | |
| Order – Buy | Ηλεκτρονική Μορφή: pdf (10 €) – Digital Type: pdf (10 €) pharmakonpress[at]pharmakonpress[.]gr | |
| Keywords | Central Nervous System (CNS), aspergillosis, acute lymphoblastic leukemia childhood | |
| Other Terms | review article | |
| Summary | Invasive fungal infections are important causes of morbidity and mortality among children receiving cancer chemotherapy or undergoing bone marrow or stem cell transplantation. Aspergillus species can cause life-threatening infections in immunocompromised and severe neutropenic pediatric patients. Cerebral aspergillosis represents the third most frequent site of invasive aspergillosis and carries a high mortality especially in immunocompromised children. We report our experience in the therapeutic management of CNS aspergillosis with a long term iv use of liposomal amphotericin B in 3 children with acute lymphoblastic leukemia (ALL) receiving remission induction therapy. Diagnosis of CNS aspergillosis was based on the clinical features (prolonged fever, severe neutropenia, vomiting, headaches), radiological and laboratory data (aspergillus DNA was detected in plasma/CSF by PCR). All children received liposomal amphotericin B for a long term (4, 10 and 12 months respectively). Based on the clinical data and laboratory/radiological exams we noticed that a favorable outcome was achieved by the prolonged use of liposomal amphotericin B with minimal infusion-related reactions and nephrotoxicity. In 2 children CNS aspergillosis lesions were eradicated, while the third one died after the discontinuation of antifungal therapy in absence of radiological findings of CNS aspergillosis. Our findings suggest that the long-term antifungal therapy with liposomal amphotericin B in children is well tolerated, effective and increases survival of these patients. | |
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Online ISSN 1011-6575
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| ΕΤΗΣΙΑ ΣΥΝΔΡΟΜΗ 2004 – ANNUAL SUBSCRIPTION 2004 | |
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