| Title | The effect of serum vitamin B12 levels on the progression of Alzheimer’s disease Dementia | |
| Author | E. Avdelidi, A. Touliou, K. Petsanis, A. Gouliova, M. Tsolaki and A. Kazis | |
| Citation | Avdelidi, E., Touliou, A., Petsanis, K., Gouliova, A., Tsolaki, M., et al.: The effect of serum vitamin B12 levels on the progression of Alzheimer’s disease Dementia, Epitheorese Klin. Farmakol. Farmakokinet. 18(1): 91-93 (2004) | |
| Publication Date | Accepted for publication: 2004 | |
| Full Text Language | English | |
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| Keywords | – | |
| Other Terms | review article | |
| Summary | Vitamin B12 and folic acid deficiencies have been associated with dementias including Alzheimer’s Disease Dementia (ADD). The aim of the present study was to examine the effect of vitamin B12 inadequacy on the progression of ADD. In the first phase of the study 387 unselected Alzheimer’s disease patients of our Outpatient Memory and Dementia Clinic were included. The diagnosis of Alzheimer’s disease was based on the criteria of DSM- IV. All patients were assessed on admission using neuropsychological tests (MMSE, CAMCOG, FRSSD, HDRS, and GDS). Biochemical parameters were measured for the determination of vitamin B12, folic acid and homocysteine (Hey), within 24h of the neuropsychological evaluation. The second phase of the study was prospective and included 68 patients of the initial group. 38 patients (group A) had normal serum vitamin B12 levels (normal values: 223-1132 pg/ml). 30 patients had low serum vitamin Bj? levels and they were given parenteral vitamin B12 supplementation therapy (intramuscular administration of hydroxycobalamin according to a standardized dosage form for 12 months). The patients of the two groups were neuropsychologically assessed 12 months later (second visit). Correlation coefficients between the biochemical parameters and the scores in the neuropsychological tests were computed. Comparison coefficients between the scores in the neuropsychological tests in the first visit and the scores after a period of one year (second visit) were computed for both studied groups. The scores in the tests in the first visit did not differ significantly from the scores in the second visit for both studied groups. A significant correlation was found between serum vitamin B12 levels and GDS scores in the first visit (p<0.001) in group B. A one-way within-subjects analysis of variance (repeated measures) was conducted to evaluate the relationship between Bt2 levels and the change in scores in the neuropsychological tests from the first to the second visit. The analysis indicated a significant difference between the two groups on HDRS scores between the two visits (p=0.006). Conclusions: Parenteral administration of vitamin B12 had no effect on the progression of ADD. Moreover, it is possible that intramuscular injection caused discontent to the patients. | |
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Online ISSN 1011-6575
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