| Title | Perillyl alcohol attenuates in vitro angiogenesis, modulates angiogenic factor production and inhibits cell proliferation and survival in endothelial and tumour cells | |
| Author | H. Loutrari1, V. Skouridou2, F.N. Kolisis2, C. Roussos1 and A. Papapetropoulos1,3
1. G.P. Livanos and M. Simou Laboratories, Evangelismos Hospital, Department of Critical Care, University of Athens School of Medicine; 2. Biotechnology Laboratory, School of Chemical Engineering, National Technical University of Athens; 3. Department of Molecular Pharmacology, School of Pharmacy, University of Patras, Patra, Greece |
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| Citation | Loutrari, H., Skouridou, V., Kolisis, F.N., Roussos, C. and Papetropoulos, A.: Perillyl alcohol attenuates in vitro angiogenesis, modulates angiogenic factor production and inhibits cell proliferation and survival in endothelial and tumour cells, Epitheorese Klin. Farmakol. Farmakokinet. 18(1): 30-32 (2004) | |
| Publication Date | Accepted for publication: 2004 | |
| Full Text Language | English | |
| Order – Buy | Ηλεκτρονική Μορφή: pdf (10 €) – Digital Type: pdf (10 €) pharmakonpress[at]pharmakonpress[.]gr | |
| Keywords | Angiogenesis, Anti-angiogenic therapy, cancer, Vascular Endothelial Growth Factor,VEGF, Ang2 | |
| Other Terms | review article | |
| Summary | Anti-angiogenic therapy is one of the most promising approaches to control cancer. In this work we studied the effects of perillyi alcohol (POH), a dietary monoterpene with in vivo anti-cancer activity on in vitro angiogenesis, expression of angiogenic ligands and cell proliferation/apoptosis using endothelial and tumour cells. We have shown that POH attenuates the capillary-like organization of cultured endothelial cells, decreases the expression of vascular endothelial growth factor (VEGF) by cancer cells, increases the expression of Angiopoietin 2 (Ang2) by endothelial ceils and inhibits ceil proliferation and survival in both cell types. We have also demonstrated that POH inhibits the phosphorylation of two key signaling molecules: Akt in endothelial cells and Erk1/2 in cancer cells. | |
| References | 1. Jones N., Iljin Κ., Dumont D.J. and Alitalo Κ.: Nature Reviews 2. 1-11 (2001)
2. Bergers G., Benjamin L.E.: Nature Reviews 3: 401-410 (2003) 3. MoehlerT.M., Ho A.D., Goldschmidt H., Barlogie B.: Crit. Rev. Oncol. Hematol. 45: 227-244 (2003) 4. Holash, J., Wiegand, S.J. and Yancopoulos, G.D.: Onco¬gene 1&. 5356-5362 (1999) 5. Crowell P.: J. Nutr. 129·. 775S-778S (1999) 6. Scouridou V., Stamatis H., Kolisis F.: Eur. J. Lipid Sci. Technol. 105: 115-120 (2003) 7. Papapetropoulos A., Desai K.M, Rudic R.D, Mayer B„ Zhang R., Ruiz-Torres M.P., Garcia-Cardena G., Madri J.A., Sessa W.C.: Am. J. Pathol. 15Ù. 1835-1844 (1997) |
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| Relative Papers |
Online ISSN 1011-6575
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Articles published in this Journal are Indexed or Abstracted in: • Chemical Abstracts • Elsevier’s Bibliographic Databases: Scopus, EMBASE, EMBiology, Elsevier BIOBASE SCImago Journal and Country Rank Factor
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| ΕΤΗΣΙΑ ΣΥΝΔΡΟΜΗ 2004 – ANNUAL SUBSCRIPTION 2004 | |
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