| Title | Prothymosin a suppresses the TGF-(31-enhanced production of tissue inhibitor of metalloproteinases- 1 but not of IL-6 in human synovial fibroblasts | |
| Author | G. Nezi1, M. Giannakouli1, S. Goura1, E, Panagiotopoulos3, A.P. Andonopoulos4, E. Giannopoulou2 and A.J. Aletras1
1Laboratory of Biochemistry, Department of Chemistry, and Departments of 2Pharmacology, 3Orthopaedic and 4Division of Rheumatology of the Department of Medicine, School of Medicine, University of Patras, Patras Greece |
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| Citation | Nezi, G., Giannakouli, M., Goura, S., Panagiotopoulos, E., Andonopoulos, A.P., et al.: Prothymosin a suppresses the TGF-(31-enhanced production of tissue inhibitor of metalloproteinases- 1 but not of IL-6 in human synovial fibroblasts, Epitheorese Klin. Farmakol. Farmakokinet. 18(1): 33-35 (2004) | |
| Publication Date | Accepted for publication: 2004 | |
| Full Text Language | English | |
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| Keywords | TGF-β1, IL- 6, TIMP-1, Prothymosin α | |
| Other Terms | review article | |
| Summary | TGF-β1 is included among main cytokines involved in the regulation of pathogenesis of rheumatoid arthritis and osteoarthritis, and is considered that it plays a protective role. TGF-β1 (1ng/ml) significantly enhances the production of IL- 6 and TIMP-1 by human synovial fibroblast in a dose (0.01-1ng/ml) and time (12-48h incubation) dependent manner. Using specific protein kinases inhibitors, it is shown that this process is mediated by protein kinase C. Prothymosin a, a bioactive acid peptide, detected in synovial membrane and fluid, dose-dependently (0.1-1pg/ml) suppresses the TGF-β1 -enhanced production of TIMP-1 but not of IL-6 by fibroblasts. The role of prothymosin a in arthritis may be considered as pro-inflammatory. | |
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Online ISSN 1011-6575
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