| Title | Alterations in brain neurotransmitters in B(a)P exposed rats: role of D2 receptors | |
| Author | Panagiotis Harkitis1, Panagiotis Tzimas1, Marios Marselos1, Elizabeth O. Johnson2 and Maria Konstandi1
1Dept of Pharmacology, Medical School, University of loannina, loannina GR-451 10, Greece; 2Dept of Anatomy, Medical School, University of loannina, loannina GR-451 10, Greece |
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| Citation | Harkitis, P., Tzimas, P., Marselos, M., Johnson, E.O. and Konstandi, M.: Alterations in brain neurotransmitters in B(a)P exposed rats: role of D2 receptors, Epitheorese Klin. Farmakol. Farmakokinet. 18(1): 117-120 (2004) | |
| Publication Date | Accepted for publication: 2004 | |
| Full Text Language | English | |
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| Keywords | B(α)P, Brain Neurotransmitters, Alterations, D2 Receptors, L-DOPA, Polycyclic Aromatic Hydrocarbon, PAH | |
| Other Terms | review article | |
| Summary | Benzo(a)pyrene (B(a)P) (10mg/kg bwx3, ip), a representative polycyclic aromatic hydrocarbon (PAH), changed dopaminergic activity in hippocampus as assessed by dopamine (DA) ieveis and turnover. This effect is likely mediated via D2 receptors, as sulpiride eliminated the stimulating effect of B(a)P. Similarly, B(a)P increased noradrenaline (NA) levels in both hypothalamus and hippocampus and sulpiride blocked this effect. L-DOPA increased DA levels and turnover in both brain sites tested, a fact that was suppressed at some extent by sulpiride. In contrast, B(a)P had no effect on serotonin levels and activity in the two brain areas. In conclusion, PAHs, known environmental pollutants, even at relatively low consentrations may cause alterations in catecholamines of hypothalamus and hippocampus, at least in part, via D2 receptors. This may be of paramount significance for several vital functions of the exposed organism as these brain sites are related, among others, to cognitive functions and the regulation of homeostasis. | |
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Online ISSN 1011-6575
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