| Title | Tie2 agonists downregulate angiopoietin-2 production | |
| Author | S. Tsigkos1, Z. Zhou1, C. Roussos1 and A. Papapetropoulos1,21G.P. Livanos and M. Simou Laboratories, Evangelismos Hospital, Critical Care Department, University of Athens School of Medicine and 2Department of Molecular Pharmacology, School of Pharmacy, University of Patras, Patra, Greece | |
| Citation | Tsigkos, S., Zhou, Z., Roussos, C. and Papapetropoulos, A.: Tie2 agonists downregulate angiopoietin-2 production, Epitheorese Klin. Farmakol. Farmakokinet. 18(1): 179-181 (2004) | |
| Publication Date | Accepted for publication: 2004 | |
| Full Text Language | English | |
| Order – Buy | Ηλεκτρονική Μορφή: pdf (10 €) – Digital Type: pdf (10 €) pharmakonpress[at]pharmakonpress[.]gr | |
| Keywords | Tie2 Agonists, Angiopoietin-2, Ang2 | |
| Other Terms | review article | |
| Summary | Angiopoietin-2 (Ang2) belongs to a novel family of angiogenic growth factors theft also includes Ang-1, Ang-3 and Ang-4. Ang-2 binds to Tie2 receptors that are expressed on endothelial cells and inhibits Ang-1-induced receptor phosphorylation. Herein, we describe the effect of the Tie2 agonists Ang1 and Ang4, on Ang2 production by endothelial cells. We have shown that Ang1 and Ang4 inhibit Ang2 production in a PI3Kinase/Akt independent manner. | |
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| Relative Papers |
Online ISSN 1011-6575
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Articles published in this Journal are Indexed or Abstracted in: • Chemical Abstracts • Elsevier’s Bibliographic Databases: Scopus, EMBASE, EMBiology, Elsevier BIOBASE SCImago Journal and Country Rank Factor
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| ΕΤΗΣΙΑ ΣΥΝΔΡΟΜΗ 2004 – ANNUAL SUBSCRIPTION 2004 | |
| Γλώσσα Πλήρους Κειμένου – Full Text Language | Αγγλικά – English |
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