Τόμος 27 (2013) – Τεύχος 3 – Άρθρο 2- Review of Clinical Pharmacology and Pharmacokinetics-Διεθνής Έκδοση – Volume 27 (2013) – Issue 3 – Article 2 – Review of Clinical Pharmacology and Pharmacokinetics-International Edition

 

Τίτλος – Title

Antioxidant and Anti-inflammatory Properties of Pistacia Lentiscus Linn: Recent Scientific Research in Wound Healing

Συγγραφέας – Author

Irini Soulioti1, Maria Papadopoulou2
1Division of Aesthetics and Cosmetology, School of Health and Caring Professions, Technological Educational Institution of Athens, Egaleo, Athens, Hellas, 2Aesthetician and Cosmetology, School of Health and Caring Professions, Technological Educational Institution of Athens, Egaleo, Athens, Hellas

Παραπομπή – Citation

Soulioti I., Papadopoulou M.: Antioxidant and Anti-inflammatory Properties of Pistacia Lentiscus Linn: Recent Scientific Research in Wound Healing, Rev. Clin. Pharmacol. Pharmacokinet. Int. Ed. 27: 107-116 (2013)

Ημερομηνία Δημοσιευσης – Publication Date
31 Δεκεμβρίου 2013 – 2013-12-31
Γλώσσα Πλήρους Κειμένου –
Full Text Language

Αγγλικά – English

Λέξεις κλειδιά – Keywords
μαστίχα, αιθέριο έλαιο, αντιοξειδωτική δράση, αντιφλεγμονώδης δράση, έγκαυμα, δέρμα
Pistacia lentiscus, mastic gum, Anacardiaceae, essential oil composition, α-pinene, β-myrcene, antioxidant potential, anti-inflammatory activity, would healing, skin closure, burn
Λοιποί Όροι – Other Terms

 

Περίληψη – Summary

 Pistacia lentiscus Linn (Family – Anacardiaceae) is an evergreen bush which is native throughout the Mediterranean region and predominately cultivated on the Greek island Chios. It grows wild also in Turkey, Marocco, Algeria, France, Spain and Italy. The resin part of this plant, known as Mastic resin, and plant named mastic tree has a great medicinal value and already has been used in traditional system of medicines. Resin of P. lentiscus has been used for variety of gastric ailments in the Mediterranean and Middle East countries for the last 3000 years. Further highlight of the discovered pharmacological effects and phytochemical properties of P. lentiscus may provide an insight to promote study and research to expand its use to modern Medicine.

Αναφορές – References
1. Bozorgi M., Memariani Z., Mobli M., Surmaghi M.H.S., Shams-Ardekani M.R., Rahimi R.: Five Pistacia species (P. vera, P. atlantica, P. terebinthus, P. khinjuk, and P. lentiscus): A Review of Their Traditional Uses, Phytochemistry and Pharmacology. Scientific World Journal, Volume 2013, Article ID 219815, 33 pages
2. Nahida, Ansari S., Siddiqui A.: Pistacia lentiscus: A review on Phytochemistry and Pharmacological properties. Int. J. Pharm. Pharm. Sci. 4(Suppl.4): 16-20 (2012)
3. Triantafyllou A., Chaviaras N., Sergentanis T.N., Protopapa E., Tsaknis J.: Chios mastic gum modulates serum biochemical parameters in a human population. J. Ethnopharm. 111: 43-49 (2007)
4. Daferera D., Pappas C., Tarantillis P.A., Pokissiou M.: Quantitative analysis of α-pinene and β-myrcene in mastic gum oil using FT-Raman spectroscopy. Food Chem. 77: 511-515 (2002)
5. Aksoy A., Duran N., Koksal F.: In vitro and in vivo antimicrobial effects of mastic chewing gum against streptococcus mutans and mutans streptococci. Arch. Oral Biol. 51: 476-481 (2006)
6. Zhou L., Satoh K., Takahashi K., Watanabe S., Nakamura W., Maki J., Hatano H., Takekawa F., Shimada C., Sakagami H.: Re-evaluation of antiinflammatory activity of mastic using activated macrophages. In Vivo 23: 583-590 (2009)
7. Giaginis C., Theocharis S.: Current evidence on the anticancer potential of Chios mastic gum. Nutr. Cancer 63: 1174-1184 (2011)
8. Trabelsi H., Cherif O.A., Sakouhi F., Villeneuve P, Renaud J., Barouh N, Boukhchina S., Mayer P.: Total lipid content, fatty acids and 4-desmethylsterols accumulation in developing fruit of Pistacia lentiscus L. growing wild in Tunisia. Food Chem. 131: 434-440 (2012)
9. Chadzopoulou A., Koukouliata A., Theodosopoulou E., Adraniotis J.: Unique mastic resin from Chios. Prog. Health Sci. 1(1): 131-136 (2011)
10. Dabos K.J., Sfika E., Vlatta L.J., Frantzi D., Amygdalos G.I., Giannikopoulos G.: Is Chios mastic gum effective in the treatment of functional dyspepsia? A prospective randomized double-blind placebo controlled trial. J. Ethnopharmacol. 127: 205-209 (2010)
11. Dhifi W., Jelali N., Chaabani E., Beji M., Fatnassi S., Omri S., Mnif W.: Chemical composition of Lentisk (Pistacia lentiscus L.) seed oil. Afr. J. Agric. Res. 8(16): 1395-1400 (2013)
12. Amhamdi H., Aouinti F., Wathelet J.P., Elbachiri A.: Chemical composition of the essential oil of Pistacia lentiscus L from Eastern Morocco. Rec. Nat. Prod. 3: 90-95 (2009)
13. Al-Habbal M.J., Al-Habbal Z., Huwez F.U.: A double-blind controlled clinical trial of mastic and placebo in the treatment of duodenal ulcer. J. Clin. Exp. Pharm. Physiol. 11: 541-544 (1984)
14. Al-Said M.S., Ageel A.M., Parmar N.S., Tariq M.: Evaluation of mastic, a crude drug obtained from Pistacia lentiscus for gastric and duodenal anti-ulcer activity. J. Ethnopharmacol. 15: 271-278 (1986)
15. Huwez F.U., Thirlwell D., Cockayne A., Ala’Aldeen D.A.: Mastic gum kills Helicobacter pylori. N. Engl. J. Med. 339(26): 1946 (1998)
16. Koutsoudaki C., Krsek M., Rodger A.: Chemical composition and antibacterial activity of the essential oil and the gum of Pistacia lentiscus Var. Chia. J. Agric. Food Chem. 53: 7681-7685 (2005)
17. Sterer N.: Antimicrobial effect of mastic gum methanolic extract against Porphyromonas gingivalis. J. Med. Food 9: 290-292 (2006)
18. Paraschos S., Magiatis P., Mitakou S., Petraki K., Kalliaropoulos A., Maragkoudakis P., Mentis A., Sgouras D., Skaltsounis A.L.: In vitro and in vivo activities of Chios mastic gum extracts and constituents against Helicobacter pylori. Antimicrob. Agents Chemother. 51: 551-559 (2007)
19. Barra A., Goroneo V., Dessi S., Cabras P., Angioni A.: Characterization of the volatile constituent in the essential oil of Pistacia lentiscus l. from different origin and its antifungal and antioxidant activity. J. Agric. Food Chem. 55: 7093-7098 (2007)
20. Sharifi M.S., Hazell S.L.: Fractionation of mastic gum in relation to antimicrobial activity. Pharmaceuticals 2(1): 2-10 (2009)
21. Janakat S., Al-Merie H.: Evaluation of hepatoprotective effect of Pistacia lentiscus, Phillyrea latifolia and Nicotiana glauca. J. Ethnopharmacol. 83: 135-138 (2002)
22. Dedoussis G.V.Z., Kaliora A.C., Psarras S., Chiou A., Mylona A., Papadopoulos N.G., Andrikopoulos N.K.: Antiatherogenic effect of Pistacia lentiscus via GSH restoration and downregulation of CD36 mRNA expression. Atherosclerosis 174: 293–303 (2004)
23. Andrikopoulos N.K., Kaliora A.C., Assimopoulou A.N., Papapeorgiou V.P.: Biological activity of some naturally occurring resins, gums and pigments against in vitro LDL oxidation. Phytother. Res. 17: 501-507 (2003)
24. He M.L., Yuan H.Q., Jiang A.L., Long A.Y., Chen W.W., Zhang P.J., Young C.Y., Zhang J.Y.: Gum mastic inhibits the expression and function of the androgen receptor in prostate cancer cells. Cancer 106: 2547-2555 (2006)
25. Heo C., Kim S.W., Kim K.J., Kim D.W., Kim H.J., Do J.H., Chang S.K.: Protective effects of mastic in non-steroidal anti-inflammatory drug induced gut damage and bacterial translocation in a rat model. Korean J. Med. 71: 354-361 (2006)
26. He M.L., Li A., Xu C.S., Wang S.L., Zhang M.J., Gu H., Tang Y.Q., Tao H.H.: Mechanisms of antiprostate cancer by gum mastic: NF-kappaB signal as target. Acta Pharmacol. Sin. 28: 446-452 (2007)
27. Benhammou N., Fawzia A.B., Tatjana K.P.: Antiradical capacity of the phenolic compounds of Pistacia lentiscus L. and Pistaciaatlantica desf. Adv. Food Sci. 29: 155-161 (2007)
28. Loutrari H., Magkouta S., Pyriohou A.., Koika V., Kolisis F., Papapetropoulos A., Roussos C.: Mastic oil from Pistacia lentiscus var. chia inhibits growth and survival of human K562 leukemia cells and attenuates angiogenesis. Nutr. Cancer 55: 86-93 (2006)
29. Balan K.V., Prince J., Han Z., Dimas K., Cladaras M., Wyche G.H., Sitaras N.M., Pantazis P.: Antiproliferative activity and induction of apoptosis in human colon cancer cells treated in vitro with constituents of a product derived from Pistacia lentiscus L. var chia. PhytoMed 2007; 14:263-272 (2010)
30. Mahmoudi M, Ebrahimzadeh MA, Nabavi SF, Hafezi S, Nabavi SM et al. Antiinflammatory and antioxidant activities of gum mastic. Eur. Rev. Med. Pharmacol. Sci. 14: 765-769 (2010)
31. Fukazawa M., Takahashi K., Watanabe K., Motohira H., Amano S., Ochiai K., Miyata T.: Mastiha gum inhibits bacterial grow in oral cavity. J. Japanese Soc. Period. 2001: 43 Issue 13(4): 86 (2001)
32. Takahashi K., Fukazawa M., Motohira H., Ochiai K., Nishikawa H., Miyata T.: A pilot study on antiplaque effect of mastic chewing gum in the oral cavity. J. Periodontol. 74: 501-505 (2003)
33. Aksoy A., Duran N., Toroglu S., Koksal F.: Short-term effect of mastic gum on salivary concentrations of cariogenic bacteria in orthodontic patients. Angle Orthod. 77: 124-128 (2007)
34. Djerrou Z., Maameri Z., Hamdi-Pacha Y., Serakta M., Riachi F., Djaalab H., Boukeloua A.: Effect of virgin fatty oil of Pistacia lentiscus on experinmental burn wound’s healing rabbits. Afr. J. Tradit. Complement. Altern. Med. 7: 258-263 (2010)
35. Maameri Z., Beroual K., Djerrou Z., Habibatni S., Benlaksira B., Serakta M., Mansour-Djaalab H., Kahlouche-Riachi, Bachtrarzi K., Hamdi Pacha Y. Preliminary study to assess cicatrizing activity of honey and Pistacia lentiscus fatty oil mixture on experimental burns in rabbits. Int. J. Medicinal Aromatic Plants 2: 476-480 (2012)
36. Charef M., Yousfi M., Saidi M., Stoccker P.: Determination of the fatty acid composition of Acorn (Quercus), Pistacia lentiscus seeds growing in Algeria. J. Am. Oil Chem. Soc. 85: 921-924 (2008)
37. Dweck A.C.: Herbal medicine for the skin. Their chemistry and effects on skin and mucous membranes. Personal Care Magazine 3(2): 271-21 (2002)
38. Lodén M., Anderson A.C.: Effect of topically applied lipids on surfactant-irritated skin. Br. J. Dermatol. 134: 215-220 (1996)
39. Siger A., Nogala-Kalucka M., Lampart-Szczapa E.: The continent and antioxidant activity of phenolic compouns in cold-pressed plant oils. J. Food Lipids 15:137-149 (2008)
40. Waterman E., Lockwood B.: Active components and clinical application of olive oil. Altern. Med. Rev. 12: 331-342 (2007)
41. Martin A.: The use of antioxidants in healing. Dermatol. Surg. 22: 156-160 (1996)
42. Palmeri B., Glauco G., Palmeri G.: Vitamin E added silicone gel sheets for treatment of hypetrophic scars and keloids. Int. J. Dermatol. 34: 506-509 (1995)
43. Toporcer T., Grendel T., Vidinsky B., Gal P., Sabo J., Hudak R.: Mechanical properties of skin wounds after Atropa belladonna application in rats. Journal Metals Materials Minerals 16(1): 25-29 (2006)
44. Kwon Y.B., Kim H.W., Roh D.H., Yoon S.Y., Baek R.M., Kim J.Y., Kweon H.Y., Lee K.G., Park Y.H., Lee J.H.: Topical application of epidermal growth factor accelerates wound healing by myofibroplast proliferation and collagen synthesis in rat. J. Vet. Sci. 7: 105-109 (2006)
45. Tanaka A., Nagate T., Matsuda H. Acceleration of wound healing by gelatin film dressing with epidermal growth factor. J. Vet. Med. Sci. 67: 909-913 (2005)
46. Varedi M., Englander E.W.; TGF-β1 Latency Associated peptide promotes remodeling of healing cutaneous wound in rat. IJMS 31: 65-69 (2006)
47. Umachigi S.P, Jayaveera K.N., Ashok Kumar C.K., Kumar G.S.: Antimicrobial, wound healing and antioxidant potential of Couroupita guianebsis in rats. Pharmacology online 3: 269-281 (2007)
48. Alizabeth A.M., Ahmadi A., Mohammadzadeh M., Paknejad M., Mohagheghi M.: The effect of HESA-A, an herbal-marine compound, on wound healing process: An experimental study. Res. J. Biol. Sci. 4: 298-302 (2009)
49. Mikhail G.R., Selak L., Salo S.: Reinforcement of surgical adhesive strips. J. Dermatol. Surg. Oncol. 12: 904-905 (1986)
50. Mikhail G.R., Selak L., Salo S., Balle M.R.: The efficacy of adhesive in the application of wound dressings. J. Burn Care Rehabil. 10: 216-219 (1989)
51. Habbu P.V., Joshi H., Patil B.: Potential wound healers fron plant origin. Pharmacognosy Rev. 1(2): 271-281 (2007)
52. Moy R.L., Quan M.B.: An evaluation of wound closure tapes. J. Dermatol. Surg. Oncol. 16: 721-723 (1990)
53. Yavuzer R., Kelly C., Durrami N., Mittal V., Jackson I., Remine S.: Reinforcement of subcuticular continuous suture closure with surgical adhesive strips and gum mastic: is there any additional strength provided? Am. J. Surg. 189: 315-318 (2005)
54. Daifas D.P., Smith, Blanchfield B., Sanders G., Austin J.W., Koukoutsis J.: Int. J. Food Microbiol. 94: 313-322 (2004)
55. Tassou C.C., Nychas G.J.E.: Antimicrobial activity of the essential oil of mastic gum (Pistacia lentiscus var. chia) on Gram positive and Gram negative bacteria in broth and in Model Food System. Int. Biodeterioration Biodegradation 36: 411-20 (1995)
56. Koukoutsis J.: Novel methods to control growth of Bacillus cereus in English-style crumpets. MSc Thesis, McGill University, Montreal, QC, 2002
57. Paraschos S., Magiatis P., Gousia P., Economou V., Sakkas H., Papadopoulou C., Skaltsounis A.L.: Chemical composition and antimicrobial properties of mastic water and its major constituents. Food Chem. 129: 907-911 (2011)
58. Paraschos S., Mitakou S., Skaltsounis A.L.: Chios gum mastic: a review of its biological activities. Curr. Med. Chem. 19: 2292-2302 (2012)
59. Vlastos D., Mademtzoglou D., Drosopoulou E., Efthimiou I., Chartomastidou T., Pandelidou C., Astyrakaki M., Chalatsi E., Mavragani-Tsipidou P.: Evaluation of the genotoxic and antigenotoxic effects of Chios mastic water by the in vitro micronucleus test on human lymphocytes and the in vivo wing somatic test on Drosophila. PloS One 8(7): 1-8 (2013)
60. Magiatis P., Melliou E., Skaltsounis A.L., Chinou I.B., Mitaku S.: Chemical composition and antimicrobial activity of the essential oils of Pistacia lentiscus var. Chia. Planta Med. 65: 749-752 (1999)
61. Iauk L, Ragausa S, Rapisarda A, Franco S, Nicolsi VM. In vitro antimicrobial activity of Pistacia lentiscus L. extract: preliminary report. J. Chemother. 8: 207-209 (1996)
62. Benhammou N., Bekkara F.A., Panovska T.K.: Antioxidant and antimicrobial activities, of the Pistacia lentiscus and pistacia atlantica extract. Afr. J. Pharm. Pharmacol. 2(2): 22-28 (2008)
63. Doi K., Wei M., Kitano M., Uematsu N., Inoue M., Wanibuchi H.: Toxic. Appl. Pharmacol. 234: 135-142 (2009)
64. Maha H., Kawtar Fikri B., Abderrahim S., Abdellah F.: Volatile components and antibacterial profile of essential oils extracted from leaves and twigs of pistacia lentiscus L.: Br. Microbiol. Res. J. 3: 602-61 (2013)
65. Abdel-Rahman A.H.Y., Youssef S.A.: Mastich as an antioxidant. J. Am. Oil Chem. Soc. 52(10): 423 (1975)
66. Abdel-Rahman A.H.Y.: Mastich and olibanum as antioxidants. Grasas Aceites (Sevilla, Spain) 27: 175-177 (1976)
67. Assimopoulou A.N., Papageorgiou V.P.: GC-MS analysis of penta- and tetra-cyclic triterpenes from resins of Pistacia species. Part I. Pistacia lentiscus var. Chia. Biomed. Chromatogr. 19: 285-311 (2005)
68. Assimopoulou A.N., Papageorgiou V.P.: GC-MS analysis of penta- and tetra-cyclic triterpenes from resins of Pistacia species. Part II. Pistacia terebinthus var. Chia. Biomed Chromatogr. 19: 586-605 (2005)
69. Kaliora A.C., Mylona A., Chiou A., Petsios D., Andrikopolous N.K.: Detection and identification of simple phenolics in Pistacia lentiscus resin. J. Liq. Chrom. Rel. Technol. 27: 289-300 (2004)
70. Abdewahed A., Skandrani I., Valenti K., Kadri M., Guiraud P., Steiman R., Mariotte A.M., Ghedira K., Laporte F., Dijoux-Franca M.G., Chekir-Ghedira L.: Study of antimutagenic and antioxidant activities of Gallic acid and 1,2,3,4,6-pentagalloyglucose from Pistacia lentiscus Confirmation by microarray expression profiling. Chem. Biol. Interact. 165: 1-13 (2007)
71. Ljubuncic P., Azaizeh H., Portnaya I., Cogan U., Said O., Saleh K.A., Bomzon A.: Antioxidant activity and cytoxicity of eight plants used in traditional Arab medicine in Israel. J. Ethnopharmacol. 99: 43-47 (2005)
72. Bhouri W., Derbel S., Skandrani I., Boubaker J., Bouhlel I., Sghaier M.B. Kilani S., Mariotte A.M., Dijoux-Franca M.G., Ghedira K., Chekir-Ghedira L.: Study of genotoxic, antigenotoxic and antioxidant activities of the digallic acid isolated from Pistacia lentiscus fruits. Toxicol In Vitro 24: 509-515 (2009)
73. Sanz M.U., Terencio M.C., Paya M.: Isolation and hypotensive activity of a polymeric procyanidin fraction from Pistacia lentiscus L. Pharmazie 47: 466-467 (1992)
74. Kaliora A.C., Stathopoulou M., Triantafillidis J.K., Dedoussis G.V.Z, Andrikopoulos N.K.: Chios mastic treatment of patients with active Crohn’s disease. World J. Gastroenterol. 13: 748-753 (2007)
75. Karbe E., Williams G.M., Lewis R.W., Kimber I., Foster P.M.: Distinguishing between adverse and non- adverse effects. Session Summary. Exp. Toxicol. Pathol. 54: 51-55 (2002)
76. Lewis R.W., Billington R., Debryune E., Gamer A., Lang B., Carpanini F.: Recognition of adverse and non-adverse effects in toxicity studies. Toxicol. Pathol. 30: 66-74 (2002)
77. Williams G.M., Iatropoulos M.J.: Alteration of liver cell function and proliferation: differentiation between adaptation and toxicity. Toxicol. Pathol. 30: 41-53 (2002)
78. Bebb J.R., Bailey-Flitter N., Ala’Aldeen D., Atherton J.C.: Mastic gum has no effect on Helicobacter Pylori load in vivo.  J. Antimicrob. Chemother. 52: 522-523 (2003)
79. Kang J.S., Wanibuchi H, Salim E., Kinoshita A., Fukushima S.: Evaluation of the toxicity of mastic gum with 13 weeks dietary administration to F344 rats. Food Chem. Toxicol. 45: 494-501 (2007)
80. Rodriguez-Peréz C., Quirantes-Pine R., Amessis-Ouchemoukh, Madani K., Segura-Carretero A., Fernandez-Gutierrez A.: A metabolite-profiling approach allows the identification of new compounds from Pistacia lentiscus leaves. J. Pharm. Biomed Anal. 77: 167-174 (2013)
81. Kottakis F., Kouzi K.K., Pendas S., Kountouras J., Choli P.T.: Effects of mastic gum Pistacia lentiscus var. Chia on innate cellular immune effectors. Eur. J. Gastroenterol. Hepatol. 21: 143-149 (2009)
82. Loizou S., Paraschos S., Mitakou S., Chrousos G.P., Lekakis I., Moutsatsou P.: Chios mastic gum extract and isolated phytosterol tirucallolexhibit anti-inflammatory activity in human aortic endothelial cells. Exp. Biol. Med. (Maywood) 234: 553-561 (2009)
83. Bosignore L., Cottiglia F., Loy G.: Antibacterial activity of Pistacia lentiscus aerial parts. Fitotherapia LXIX 6: 537-538 (1998)
84. Marner F.Z., Freyer A., Lex J.: Triterpenoids from gum mastic, the resin of Pistacia lentiscus. Phytochemistry 30: 3709-3712 (1991)

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