|
Τίτλος – Title
|
The Virgin Olive Oil Model of Essential Fatty Acid Metabolism: New Aspects on Inflammation and Carcinogenesis via the LOX Pathway of Biodegradation of Lipids |
|
|
Συγγραφέας – Author
|
Ioanna Grech, Anthony M. Kyriakopoulos, Maria Grech and Vasiliki-Sofia Grech |
|
|
Παραπομπή – Citation
|
Grech I., Kyriakopoulos A. M., Grech M.,Grech V. S. .: The Virgin Olive Oil Model of Essential Fatty Acid Metabolism: New Aspects on Inflammation and Carcinogenesis via the LOX Pathway of Biodegradation of Lipids, Rev. Clin. Pharmacol. Pharmacokinet. Int. Ed. 27: 117-122 (2013) |
|
|
Ημερομηνία Δημοσιευσης – Publication Date
|
31 Δεκεμβρίου 2013 – 2013-12-31
|
|
|
Γλώσσα Πλήρους Κειμένου –
Full Text Language |
Αγγλικά – English |
|
|
Λέξεις κλειδιά – Keywords
|
παρθένο ελαιόλαδο, αραχιδονικό οξύ, φλεγμονή, μεταστατική καρκινογέννεση, καλυντική χρήση των ελαίων
Virgin olive oil, arachidonic acid, LOX pathway, 5-OXO-ETE, HETE, inflammation, metastatic carcinogenesis, cosmetic use of oils |
|
|
Λοιποί Όροι – Other Terms
|
|
|
|
Περίληψη – Summary
|
Virgin Olive Oil is a unique divine mixture of extreme biological value. The percentage of essential fatty acids, phenolic, sterolic and stanolic composition reflect its nutritional and pharmaceutical characteristics. Recent data of progress on Lipoxygenase metabolic pathway of arachidonic acid has proven molecules like 5-OXO-HETE responsible for inflammation and meta-static carcinogenesis. Special attention should be drawn for suitability of the chronic use of Virgin Olive Oil and other oils as in mixtures like cosmetic devices, instead of consuming as a food.
|
|
|
Αναφορές – References
|
1. Vichi S., Romero A., Tous J., Caijach J.: The activity of healthy olive microbiota during virgin olive oil extraction influences olive oil composition. J. Agric. Food Chem. 59: 4705-4714 (2011) 2. Muzzalupo I., Macchione B., Bucci C.,Stefanizzi F.,Perri E.,Chiappetta A., Tagarelli A., Sindona G.: LOX gene transcript accumulation in olive (Olea Europaea L.) fruits at different stages of maturation : Relationship between volatile compounds, environmental factors and technological treatments for oil extraction. Scientific World Journal. May (1), (2012), doi: 10.1100/2012/532179 3. Souyris S.I., Bervillé A.J.: An insertion of oleate denaturase homologous sequence silences via siRNA the functional gene leading to high oleic acid content in sunflower seed oil. Mol. Gen. Genomics. 281(1): 43-54 (2009) 4. Servili M., Esposto S., Lodolini E., Selvaggini R., Taticchi A., Urbani S., Montedoro G., Serravalle M., Gucci R.: Irrigation effects on quality, phenolic composition, and selected volatiles of virgin olive oils cv. Leccino. J. Agric. Food Chem. 55: 6609-6618 (2007) 5. Liavonchanka A., Feussner I.: Lipoxygenases: occurrence, functions and catalysis. J. Plant Physiol. 163: 348-357 (2006) 6. Kumar S., Vijayan V., Bhaskar S., Krishnan K., Shalini V., Helen A.: Anti-inflammatory potential of an ethyl acetate fraction isolated from Justisia gentarussa roots through inhibition of iNOS and COX-2 expression via the NF-kB pathway. Cell Immunol. 272: 283-289 (2012) 7. Maury J., Casanova J., Berti L.: Purification, product characterization and kinetic properties of lipoxygenase from olive fruit (Olea europaea L.). Plant Physiol. Biochem. 44: 450-454 (2006) 8. Nocuchi M., Miyano M., Kuhara S., Matsumoto T., Noma M.: Interfacial kinetic reaction of human 5-lipoxygenase. Eur. J. Biochem. 222: 285-282 (1994) 9. Marcus A.: The eicosanoids in biology and medicine. J. Lipid. Res. 25: 1511-1516 (1984) 10. Parkinson J.F.: Lipoxin and synthetic lipoxin analoques: an overview of anti-inflammatory functions and new concepts in immunomodulation. Inflamm. Allergy Drug Targets 5: 91-106 (2006) 11. MacGuire J., McGee J., Crittenden N., Fitzpatrick F.: Cell damage unmasks 15-lipoxygenase activity in human neutrophils. J. Biol. Chem. 260: 8316-8319 (1985) 12. Patel P., Anumolu J.R., Powell W.S., Rokach J.: 5-OXO-15-HETE: Total synthesis and Bioactivity. Biorg. Med. Chem. Lett. 21: 1857-1860 (2011) 13. Brash A.R.: Lipoxygenases: occurrence, functions, catalysis, and acquisition of substrate. J. Biol. Chem. 274: 23679-23682 (1999) 14. Padilla M.N., Anumolu J.R., Powell W.S., Rokach J.: Functional characterization of two 13-lipoxygenase genes from olive fruit in relation to the biosynthesis of volatile compounds of virgin olive oil. J. Agric. Food Chem. 57: 9097-9107 (2009) 15. Pommery J., Pommery N., Hénichart J.P.: Modification of eicosanoid profile in human blood treated by dual COX/LOX inhibitors. Prostanglandins Leukot. Essent Fatty Acids 73: 411-417 (2005) 16. Verdramini-Costa D.B., Carvalho J.E.: Molecular link between inflammation and cancer. Curr. Pharm. Des. 18: 3831-3852 (2012) 17. Olías J.M., Pérez A.G., Ríos J.J., Sanz L.C.: Aroma of virgin olive oil: biogenesis of the green odor notes. J. Agric. Food Chem. 41: 2368-2373 (1993) 18. Cavaliere B., de Nino A., Hayet F., Lazez A., Macchi-one B., Moncef C., Perri E., Sindona G., Tagarelli A.: A metabolomic approach to the evaluation of the origin of extra virgin olive oil: a convenient statistical treatment of mass spectrometric analytical data. J. Agric. Food Chem. 55: 1454-1462 (2007) 19. Padilla M.N., Hernández M.L., Sanz C., Martínez-Rivas J.M.: Functional characterization of two 13-lipoxygenase genes from olive fruit in relation to the biosynthesis of volatile compounds of virgin olive oil. J. Agric. Food Chem. 57: 9097-9107 (2009) 20. Russo A., Sindonaa G., Tagarellia A.: Amino acids as modulators of lipoxygenase oxidation mechanism. The identification and structural characterization of spin adducts intermediates by electron spin resonance and tandem mass spectrometry. Food Chem.119: 533-538 (2010) 21. Higgs G.A., Salmon J.A., Spayne J.A.: The inflam-matory effects of hydroperoxy and hydroxyl acid products of arachidonate lypoxygenase in rabbit skin. Br. J. Pharmacol. 74. 479-433 (1981) 22. Cardevila J., Pramanik B., Napoli J.L., Manna S., Falck J.R.: Arachidonic acid epoxidation: epoxyeicosatrienoic acids are constituents of rat liver. Arch. Biochem. Biophys. 231: 511-517 (1984) 23. Gaffney B.J.: Locating a lipid at the portal of lipoxygenase active site. Biophys. J. 103: 2134-2144 (2012) 24. Powell W.S.: Biochemistry, biology and chemistry of the lipoxygenase product 5-OXO-ETE. Prog. Lipid. Res. 44:154-183 (2005) 25. Le Fauder P., Baillif V., Spreadbury I., Motta J.P., Rousset P., Chêne G., Guigné C., Tercé F., Vanner S., Vergnolle N., Bertrand-Michel J., Dubourdeau M., Cenac N.: LS MS/MS method for rapid and concominant quantification of pro-inflammatory and pro-resolving polyunsaturated fatty acids. J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. 932: 123-133 (2013) 26. Li N., Sood S., Wang S., Fang M., Wang P., Sun Z., Yang C.S., Chen X.: Overexpression of 5-lipoxygenase and cycloxygenase 2 in hamster and human oral cancer and chemopreventive effects of Zileuton and and celecoxib. Clin. Cancer Res. 11: 2089-2096 (2005) 27. Sarveswaran S., Ghosh J.: OXER1, a G protein-coupled oxoeicosatetraenoid receptor, mediates the survival-promoting effects of arachidonate 5-lipoxygenase in prostate cancer cells. Cancer Lett. 336: 185-195 (2013) 28. Pidgeon G.P., Kandouz M., Meram A., Honn K.V.: Mechanisms controlling cell cycle arrest and induction of apoptosis after 12-lipoxygenase inhibition in prostate cancer cells. Cancer Res. 62: 2721-2727 (2002) 29. Frolov A., Dong H., Jiang M., Yang L., Cook E.C., Matnani R., Hammock B.D., Crofford L.J.: Niemann-Pick type C2 deficiency in human fibroblast confers robust and selective activation of prostaglandin E2 biosynthesis. J. Biol. Chem. 288: 23696-23703 (2013) 30. Jiang J., Dingledin R.: Prostaglandin E2 receptor EP2 in the crosshairs of anti-inflammation,anti-cancer and neuroprotection. Trends Pharmacol. Sci. 34: 413-423 (2013) 31. Grant G.E., Rokach J., Powell W.S.: 5-OXO-ETE and the OXO receptor. Prostaglandins Other Lipid Mediat. 89(3-4): 98-104 (2009) 32. Jemal A., Tiwari R.C., Murray T., Ghafoor A., Samuels A., Ward E., Feuer E.J., Thun M.J.; American Cancer Society: Cancer statistics. CA Cancer J Clin. 54(1): 8-29 (2004) 33. Takaaki M., Arima Y., Nagano O., Saya H.: Lysyl Oxidase Is Induced by Cell Density-Mediated Cell Cycle Suppression via RB-E2F1-HIF-1α Axis. Cell Struct. Funct. 38: 9-14 (2013) 34. Mackenzie J., Ah-See K,, Thakker N,, Sloan P,, Maran A,G,, Birch J,, Macfarlane G,J.: Increasing incidence of oral cancer amongst young persons. What is the etiology? Oral Oncol. 36: 387-389 (2000) 35. Guo Y., Wang X., Zhang X., Sun Z., Chen X.: Ethanol promotes chemically induced oral cancer in mice through activation of the 5-lipoxygenase pathway of arachidonic acid metabolism. Cancer Prev Res. 4: 1863-1872 (2011) 36. Olaso E., Lin H.C., Wang L.H., Friedman S.L.: Impaired dermal wound healing in discoidin domain receptor 2-deficient mice associated with defective extracellular matrix remodeling. Fibrogenesis Tissue Repair 4(1): 5 (2011) 37. Yan Y., Wang B., Zuo Y.G., Qu T.: Inhibitory effects of mizolastine on ultraviolet B-induced B4 production and the 5-lipoxygenase expression in normal human dermal fibroblasts in vitro. Photochem Photobiol. 82: 665-669 (2006) 38. Air J.M., Harris J.I.: DNA dependent RNA polymerase from the thermophilic bacterium Thermus aquaticus. FEBS Lett. 38: 277-281 (1974) |
Online ISSN 1011-6583