|
Τίτλος – Title
|
Συγκριτική Μελέτη της Επίδρασης της Θεοφυλλίνης στο Γαστρεντερικό Σωλήνα του Κουνελιού Differential effects of theophylline along the digestive tract of the rabbit: a comparative study from the oesophagus to the colon |
|
|
Συγγραφέας – Author
|
Θεοφανώ Α. Ψαρρά1, Γεώργιος Χ. Μπατζίας1, Theo L. Peeters2, Μαρία Κουτσοβίτη – Παπαδοπούλου1 1Εργαστήριο Φαρμακολογίας, Κτηνιατρική Σχολή, Αριστοτέλειο Πανεπιστήμιο, Θεσσαλονίκη, Ελλάδα Theophano A. Psarra1, Georgios C. Batzias1, Theo L. Peeters2, Maria Koutsoviti – Papadopoulou1 1Laboratory of Pharmacology, Veterinary Faculty, Aristotle University, Thessaloniki, Greece, 2Gut Peptide Laboratory, Faculty of Medicine, University of Leuven, Belgium |
|
|
Παραπομπή – Citation
|
Ψαρρά,Θ., Μπατζίας,Γ., Peeters,Τ., Κουτσοβίτη-Παπαδοπούλου,Μ. : Συγκριτική Μελέτη της Επίδρασης της Θεοφυλλίνης στο Γαστρεντερικό Σωλήνα του Κουνελιού, Επιθεώρηση Κλιν. Φαρμακολ. Φαρμακοκινητ. 27: 120-123 (2009)
Psarra,T., Batzias,G., Peeters,T., Koutsoviti-Papadopoulou,M. : Differential effects of theophylline along the digestive tract of the rabbit: a comparative study from the oesophagus to the colon, Epitheorese Klin. Farmakol. Farmakokinet. 27: 120-123 (2009)
|
|
|
Ημερομηνία Δημοσιευσης – Publication Date
|
8 Μαρτίου 2009 – 2009-03-08
|
|
|
Γλώσσα Πλήρους Κειμένου –
Full Text Language |
Ελληνικά – Greek |
|
|
Παραγγελία – Αγορά –
Order – Buy |
Ηλεκτρονική Μορφή: pdf (15 €) –
Digital Type: pdf (15 €) pharmakonpress[at]pharmakonpress[.]gr |
|
|
Λέξεις κλειδιά – Keywords
|
Θεοφυλλίνη, γαστρεντερικός σωλήνας, μη αδρενεργική μη χολινεργική χαλαρωτική επίδραση, αναστολή φωσφοδιεστεράσης
Theophylline; gastrointestinal tract; non-adrenergic non-cholinergic relaxing effect; cholinergic effect; phosphodiesterase inhibition
|
|
|
Λοιποί Όροι – Other Terms
|
Άρθρο Article |
|
|
Περίληψη – Summary
|
– This study reveals differential dose-related effects and mechanisms of theophylline’s action along the rabbit digestive tract. Up to the concentration of 10-3 M, theophylline relaxes all regions of the upper gastrointestinal tract, in a declining order from the lower esophageal sphincter (LES) to the pylorus, but only the ascending colon from the lower gastrointestinal tract; this effect persists under non-adrenergic non-cholinergic (NANC) conditions and it is not modified by hexamethonium (HEX) or by L-NAME. At concentrations higher than 10-3 M, the theophylline’s relaxing effect on the antrum and pylorus is reversed into a considerable atropine-sensitive contractile one. In the small intestine, theophylline produces a weak atropine- and HEX-sensitive increase in tone, which at concentrations higher than 10-3 M becomes very strong. Available information suggests that the relaxing effect of theophylline is due to cAMP elevation mediated through its inhibitory action on the phosphodiesterases (PDEs), while its stimulatory effect involves a cholinergic pathway. |
|
|
Αναφορές – References
|
1. Hirano T., Yamagata T., Gohda M. et al.: Inhibition of reactive nitrogen species production in COPD airways: Comparison between inhaled corticosteroids and oral theophylline. Thorax 61: 761-766 (2006)
2. Cyr M.C., Beauchesne M.F., Lemière C., Blais L.: Effect of theophylline on the rate of moderate to severe exacerbations among patients with chronic obstructive pulmonary disease. Br. J. Clin. Pharmacol. 65: 40-50 (2008) 3. Tottrup A., Forman A., Madsen G., Andersson K.E.: The actions of some b-receptor agonists and xanthines on isolated muscle strips from the human oesophagogastric junction. Pharmacol. Toxicol. 67: 340-343 (1990) 4. Park H., Clark E., Conklin J.L.: Effects of phosphodiesterase inhibitors on oesophageal neuromuscular functions. Neurogastroenterol. Motil. 15: 625-633 (2003) 5. Tsugeno M., Huang S.M., Pang Y.W., Chowdhury J.U., Tomita T.: Effects of phosphodiesterase inhibitors on spontaneous electrical activity (slow waves) in the guinea-pig gastric muscle. J. Physiol. 485: 493-502 (1995) 6. Tonini M., Onori L., Lecchini S., Frigo G. Perucca E., Crema A.: Mode of action of ATP on propulsive activity in rabbit colon. Eur. J. Pharmacol. 82: 21-28 (1982) 7. Pfaffman M.A., McFarland S.A.: The effects of theophylline and cyclic AMP on intestinal smooth muscle contractions. Eur. J..Pharmacol. 23: 147-152 (1973) 8. Fischer T.A., Erbel R., Treese N.: Current status of phosphodiesterase inhibitors in the treatment of congestive heart failure. Drugs 449: 28-45 (1992) 9. Pauwels R.A., Joos G.F.: Characterization of the adenosine receptors in the airways. Arch. Intern. Pharmacodyn. Thér. 329:151-160 (1995) |
|
Online ISSN 1011-6575
• Elsevier’s Bibliographic Databases: Scopus, EMBASE, EMBiology, Elsevier BIOBASE
SCImago Journal and Country Rank Factor
Articles published in this Journal are Indexed or Abstracted in:
• Chemical Abstracts
• Elsevier’s Bibliographic Databases: Scopus, EMBASE, EMBiology, Elsevier BIOBASE
SCImago Journal and Country Rank Factor
Τι είναι η Επιθεώρηση Κλινικής Φαρμακολογίας και Φαρμακοκινητικής-Ελληνική Έκδοση-Οδηγίες προς τους Συγγραφείς
What is Epitheorese Klinikes Farmakologias και Farmakokinetikes-Greek Edition-Instrunctions to Authors
Άρθρα Δημοσιευμένα στην Επιθεώρηση Κλινικής Φαρμακολογίας και Φαρμακοκινητικής-Ελληνική Έκδοση
Articles Published in Epitheorese Klinikes Farmakologias και Farmakokinetikes-Greek Edition
Συντακτικη Επιτροπή-Editorial Board
|
ΕΤΗΣΙΑ ΣΥΝΔΡΟΜΗ – ANNUAL SUBSCRIPTION
|
||
|
Γλώσσα Πλήρους Κειμένου –
Full Text Language |
Ελληνικά – Greek
|
|
|
Παραγγελία – Αγορά –
Order – Buy |
pharmakonpress[at]pharmakonpress[.]gr
|
|
|
pharmakonpress[at]pharmakonpress[.]gr
|
||