Τίτλος – Title
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Χρήση Κανναβινοειδών στην Κλινική Πράξη Cannabinoids in Clinical Practice |
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Συγγραφέας – Author
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Σοφία Κωστούδη, Χαρίκλεια Κουτούση, Μαρία Μυρωνίδου-Τζουβελέκη Εργαστήριο Φαρμακολογίας, Ιατρική Σχολή, Αριστοτέλειο Πανεπιστήμιο, Θεσσαλονίκη, Ελλάς Sofia Kostoudi, Chariklia Koutousi, Maria Mironidou-Tzouveleki Department of Pharmacology, Medical School, Aristotle University, Thessaloniki, Greece |
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Παραπομπή – Citation
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Κωστούδη,Σ., Κουτούση,Χ., Μυρωνίδου-Τζουβελέκη,Μ. : Χρήση Κανναβινοειδών στην Κλινική Πράξη,Επιθεώρηση Κλιν. Φαρμακολ. Φαρμακοκινητ. 23: 265-272 (2005) Kostoudi,S., Koutousi,Ch., Mironidou-Tzouveleki,M. : Serotoninergic System: Cannabinoids in Clinical Practice, Epitheorese Klin. Farmakol. Farmakokinet. 23: 265-272 (2005) |
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Ημερομηνία Δημοσιευσης – Publication Date
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15 Σεπτεμβρίου 2005 – 2005-09-15
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Γλώσσα Πλήρους Κειμένου –
Full Text Language |
Ελληνικά – Greek |
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Ηλεκτρονική Μορφή: pdf (15 €) –
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Λέξεις κλειδιά – Keywords
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Κανναβινοειδή, τετραϋδροκανναβινόλη (THC), κανναβιδιόλη (CBD), κανναβιγερόλη (CBG), υποδοχείς κανναβινοειδών (CB1, CB2)
Cannabinoids, tetrahydrocannabinol (THC), cannabidiol (CBD), cannabigerol (CBG), cannabinoids receptors (CB1, CB2)
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Λοιποί Όροι – Other Terms
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Άρθρο Article |
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Περίληψη – Summary
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Η ινδική κάνναβις περιέχει τουλάχιστον 460 χημικές ενώσεις και περισσότερα από 60 αλκαλοειδή, κανναβινοειδή. Τα κανναβινοειδή με εφαρμογή στην κλινική πράξη είναι η τετραϋδροκανναβινόλη, η κανναβιδιόλη και η κανναβιγερόλη. Τα κανναβινοειδή χρησιμοποιούνται συχνά για τους μυϊκούς σπασμούς σε ασθενείς με πολλαπλή σκλήρυνση, για την αντιμετώπιση του άλγους και για την αντιμετώπιση εμέτων και ναυτίας σε ασθενείς που υποβάλλονται σε χημειοθεραπεία. Ο στόχος για τη χρήση των κανναβινοειδών στην ιατρική πράξη είναι η ανεύρεση αποτελεσματικών τρόπων και δόσεων χορήγησής τους, ώστε να αποφευχθούν οι ανεπιθύμητες ενέργειες στη ψυχική σφαίρα. The marihuana plant contains more than 460 known compounds, of which more than 60 have the 21-carbon structure typical of cannabinoids. The cannabinoids that could be used as medicaments are: Delta-9-tetrahydrocannabinol (THC), cannabidiol (CBD) and cannabigerol (CBG). Today the efficacy of THC in reducing nausea and vomiting associated with cancer chemotherapy is well known. The cannabinoids could also be effective in reducing spasticity in multiple sclerosis as well as in alleviating neuropathic pain. The main challenge for the medical use of cannabinoids is the development of safe and effective methods of use that lead to therapeutic effects but that avoids adverse psychoactive effects. |
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Αναφορές – References
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