Τόμος 35 (2017) – Τεύχος 3 – Άρθρο 2 – Επιθεώρηση Κλινικής Φαρμακολογίας και Φαρμακοκινητικής – Ελληνική Έκδοση – Volume 35 (2017) – Issue 3 – Article 2 – Epitheorese Klinikes Farmakologias και Farmakokinetikes – Greek Edition

Από | | Άρθρο - Article, Πλήρες Κείμενο στα Ελληνικά - Full Text in Greek
Τίτλος – Title

Προβλήματα και Νεώτερες Εξελίξεις στη Μεθοδολογία Μέτρησης της Αντιμυλλέριας Ορμόνης (ΑΜΗ)

Issues of Methodology In Current Antimullerian Hormone (AMH) Assays
Συγγραφέας – Author

Μαρία Τσαλίδου, Παρασκευή Παπαϊωαννίδου

A΄ Εργαστήριο Φαρμακολογίας, Τμήμα Ιατρικής, Σχολή Επιστημών Υγείας, Αριστοτέλειο Πανεπιστήμιο Θεσσαλονίκης, Θεσσαλονίκη, Ελλάδα

Maria Tsalidou, Paraskevi Papaioannidou

1st Department of Pharmacology, School of Medicine, Faculty of Health Sciences, Aristotle University of Thessaloniki, Thessaloniki, Greece
Παραπομπή – Citation
Επιθεώρηση Κλιν. Φαρμακολ. Φαρμακοκινητ. 35: 103-110 (2017)
Epitheorese Klin. Farmakol. Farmakokinet. 35: 103-110 (2017)
Ημερομηνία Δημοσιευσης – Publication Date
10 Ιουλίου 2017 – 2017-07-10
Γλώσσα Πλήρους Κειμένου –
Full Text Language

Ελληνικά – Greek
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Λέξεις κλειδιά – Keywords
ΑΜΗ, ELISA, μέθοδοι μέτρησης της AMH, αυτοματοποιημένες μέθοδοι μέτρησης της AMH
AMH, ELISA, AMH assay, AMH automated assay
Λοιποί Όροι – Other Terms

Άρθρο

Article
Περίληψη – Summary

Η αντιμυλλέρια ορμόνη (ΑΜΗ)  παράγεται από την ανθρώπινη ωοθήκη κατά την ωοθυλακιογένεση και αποτελεί σήμερα τον πιο αξιόπιστο δείκτη εκτίμησης της δεξαμενής των ωοθυλακίων. Η μέτρηση της επιτυγχάνεται στον ορό με τη χρήση ανοσοενζυμικών μεθόδων με μονοκλωνικά αντισώματα. Οι υπάρχουσες μη αυτοματοποιημένες μέθοδοι παρουσιάζουν προβλήματα σχετικά με την δυνατότητα σύγκρισης των μετρήσεων της ΑΜΗ, οι οποίες εμφανίζουν αποδεκτή ακρίβεια και επαναληψιμότητα των τιμών όταν οι μετρήσεις γίνονται στο ίδιο εργαστήριο  αλλά εμφανίζουν μεγάλου βαθμού διαφοροποιήσεις μεταξύ διαφορετικών εργαστηρίων. Αυτή η ασυμφωνία έχει δημιουργήσει προβλήματα στον προσδιορισμό των κριτικών τιμών της ορμόνης (cut off values) που απαιτούνται για τη λήψη κλινικών αποφάσεων. Αλλά και η είσοδος των νεότερων αυτοματοποιημένων μεθόδων, παρά την ακρίβεια και την ευκολία στη χρήση, δε φαίνεται να λύνει το πρόβλημα, διότι οι μετρήσεις τους δεν συμφωνούν με αυτές των δύο προγενέστερων μη αυτοματοποιημένων ανοσοενζυμικών μεθόδων μέτρησης της ορμόνης. Για αυτό το λόγο, κρίνεται απαραίτητη η εδραίωση διεθνών οδηγιών (guidelines) σε όλα τα εργαστήρια για τη μέτρηση της ΑΜΗ, ώστε να παράγονται αξιόπιστα και απολύτως συγκρίσιμα μεταξύ τους αποτελέσματα, τα οποία θα είναι χρήσιμα στην κλινική πράξη.

Anti-Müllerian hormone (AMH) is produced by the granulosa cells of early developing follicles in the ovary, and is considered to be a sensitive marker of the ovarian follicle pool. Measurement of serum AMH levels is performed using enzyme linked immunuoassays with monoclonal antibodies. However, the observed dis-agreement in AMH values when measured by different AMH assays has caused considerable problems in determining the critical cut-off values of the hormone that are required for clinical decision making. The newer automated methods, although more accurate and easy to use, do not seem to solve the problem, because they give AMH values that do not match those obtained by the two previous standard immunoenzymatic assays. Thus, there is a great need in establishing international guidelines in order to obtain reliable and inter-laboratory compatible AMH values that will be useful in clinical practice.
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